Secnidazole

What is Secnidazole

Secnidazole is an oral nitroimidazole antimicrobial indicated for the treatment of bacterial vaginosis in adult women.

Secnidazole is approved as single-dose therapy, which was found to be at least as effective as a 7-day course of metronidazole for bacterial vaginosis.

In a double-dummy, double-blind, noninferiority study (n = 577), therapeutic success, a composite of clinical and bacteriological cure, rates at day 28 were similar, 60.1% and 59.5% for single-dose secnidazole vs. multiple-dose metronidazole (500 mg PO twice daily for 7 days), respectively. Single-dose therapy increases convenience and promotes compliance.

Brand Name

SOLOSEC

Indications & Dosage

  • bacterial vaginosis
  • Bacteroides sp.
  • Gardnerella vaginalis
  • Megasphaera-like type 1
  • Megasphaera-like type 2
  • Mobiluncus sp.
  • Prevotella sp.

Side Effects

  • abdominal pain
  • candidiasis
  • diarrhea
  • dysgeusia
  • headache
  • nausea
  • vaginitis
  • vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • neoplastic disease
  • pregnancy

Interactions

  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
You cannot copy content of this page