What is Secnidazole
Secnidazole is an oral nitroimidazole antimicrobial indicated for the treatment of bacterial vaginosis in adult women.
Secnidazole is approved as single-dose therapy, which was found to be at least as effective as a 7-day course of metronidazole for bacterial vaginosis.
In a double-dummy, double-blind, noninferiority study (n = 577), therapeutic success, a composite of clinical and bacteriological cure, rates at day 28 were similar, 60.1% and 59.5% for single-dose secnidazole vs. multiple-dose metronidazole (500 mg PO twice daily for 7 days), respectively. Single-dose therapy increases convenience and promotes compliance.
Brand Name
SOLOSEC
Indications & Dosage
- bacterial vaginosis
- Bacteroides sp.
- Gardnerella vaginalis
- Megasphaera-like type 1
- Megasphaera-like type 2
- Mobiluncus sp.
- Prevotella sp.
Side Effects
- abdominal pain
- candidiasis
- diarrhea
- dysgeusia
- headache
- nausea
- vaginitis
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- breast-feeding
- neoplastic disease
- pregnancy
Interactions
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
