Riluzole

What is Riluzole

Riluzole is an oral glutamate antagonist approved for the treatment of amyotrophic lateral sclerosis (ALS).

Riluzole does not cure the disease or improve symptoms, but it might prolong the survival of patients by approximately 3 months.

Riluzole appears to be more effective in patients with bulbar-onset disease than for those with limb-onset disease.

Riluzole has been used off-label for the treatment of chorea associated with Huntington’s disease.

Brand Names

  • Rilutek
  • Tiglutik

Indications

  • amyotrophic lateral sclerosis (ALS)
  • Huntington’s Disease (Huntington’s Chorea)

Side Effects

  1. abdominal pain
  2. amnesia
  3. anaphylactoid reactions
  4. anorexia
  5. arthralgia
  6. asthenia
  7. cough
  8. cystitis
  9. diarrhea
  10. dizziness
  11. drowsiness
  12. elevated hepatic enzymes
  13. flatulence
  14. headache
  15. hepatitis
  16. hypertension
  17. hypoesthesia
  18. insomnia
  19. interstitial lung disease
  20. nausea
  21. neutropenia
  22. pancreatitis
  23. paresthesias
  24. peripheral edema
  25. pneumonitis
  26. pruritus
  27. rhinitis
  28. sinus tachycardia
  29. vertigo
  30. vomiting
  31. xerostomia

Monitoring Parameters

  • LFTs
  • neurologic function
  • serum bilirubin

Contraindications

  • Asian patients
  • breast-feeding
  • hepatic disease
  • pregnancy

Interactions

  • Allopurinol
  • Amiodarone
  • Amlodipine; Atorvastatin
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aspirin, ASA; Omeprazole
  • Atorvastatin
  • Atorvastatin; Ezetimibe
  • Auranofin
  • Azathioprine
  • Barbiturates
  • Busulfan
  • Cannabidiol
  • Carbamazepine
  • Chlorpromazine
  • Ciprofloxacin
  • Dantrolene
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deferasirox
  • Dextromethorphan; Quinidine
  • Diclofenac
  • Diclofenac; Misoprostol
  • Didanosine, ddI
  • Dienogest; Estradiol valerate
  • Diphenhydramine; Ibuprofen
  • Disulfiram
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix; Estradiol; Norethindrone acetate
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Floxuridine
  • Flutamide
  • Fluvoxamine
  • Fosphenytoin
  • Green Tea
  • Halothane
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrocodone; Ibuprofen
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Infliximab
  • Interferon Alfa-2a
  • Interferon Alfa-2b
  • Interferon Alfa-2b; Ribavirin
  • Interferon Alfa-n3
  • Interferon Alfacon-1
  • Interferon Beta-1a
  • Interferon Beta-1b
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ketoconazole
  • Leflunomide
  • Lesinurad; Allopurinol
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Lopinavir; Ritonavir
  • Mercaptopurine, 6-MP
  • Mestranol; Norethindrone
  • Methotrexate
  • Methoxsalen
  • Methyldopa
  • Mexiletine
  • Minocycline
  • Modafinil
  • Nevirapine
  • Niacin; Simvastatin
  • Nitrofurantoin
  • Norethindrone
  • Norgestrel
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Peginterferon beta-1a
  • Pexidartinib
  • Phenytoin
  • Propylthiouracil, PTU
  • Pyrazinamide, PZA
  • Quinidine
  • Quinine
  • Rifampin
  • Ritonavir
  • Rucaparib
  • Segesterone Acetate; Ethinyl Estradiol
  • Simvastatin
  • Simvastatin; Sitagliptin
  • St. John’s Wort, Hypericum perforatum
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulindac
  • Tacrine
  • Telithromycin
  • Teriflunomide
  • Testosterone
  • Thiabendazole
  • Thioguanine, 6-TG
  • Ticlopidine
  • Tipranavir
  • tobacco
  • Valproic Acid, Divalproex Sodium
  • Vemurafenib
  • Zafirlukast
  • Zileuton
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