Rilpivirine

What is Rilpivirine

Rilpivirine is an oral, diarylpyrimidine, non-nucleoside reverse transcriptase inhibitor (NNRTI).

It is indicated for use with other antiretroviral agents to treat HIV-1 infection in antiretroviral treatment-naive patients 12 years and older and weight at least 35 kg with HIV-1 RNA concentrations of 100,000 copies/mL or less at initiation of therapy. 

Brand Name

EDURANT

Indications

  1. human immunodeficiency virus (HIV)
  2. human immunodeficiency virus (HIV) infection
  3. human immunodeficiency virus (HIV) prophylaxis

Side Effects

  1. abdominal pain
  2. abnormal dreams
  3. adrenocortical insufficiency
  4. anxiety
  5. breast enlargement
  6. cholecystitis
  7. cholelithiasis
  8. Cushingoid features
  9. depression
  10. depression
  11. diarrhea
  12. dizziness
  13. drowsiness
  14. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  15. dysphoria
  16. elevated hepatic enzymes
  17. fatigue
  18. glomerulonephritis
  19. gynecomastia
  20. headache
  21. hyperbilirubinemia
  22. hypercholesterolemia
  23. hypertriglyceridemia
  24. insomnia
  25. lipodystrophy
  26. nausea
  27. nephrolithiasis
  28. nephrotic syndrome
  29. rash
  30. suicidal ideation
  31. vomiting

Monitoring Parameters

  • blood glucose
  • CBC with differential
  • CD4+ T cell count
  • hepatitis B serology
  • LFTs
  • plasma hepatitis C RNA
  • plasma HIV RNA
  • pregnancy testing
  • serum bilirubin (total and direct)
  • serum cholesterol
  • serum creatinine
  • serum lipid profile
  • urinalysis

Contraindications

  • alcoholism
  • autoimmune disease
  • bradycardia
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • children
  • coronary artery disease
  • depression
  • diabetes mellitus
  • females
  • geriatric
  • Graves’ disease
  • Guillain-Barre syndrome
  • heart failure
  • hepatic disease
  • hepatitis B and HIV coinfection
  • hepatitis C and HIV coinfection
  • human immunodeficiency virus (HIV) infection resistance
  • hypercholesterolemia
  • hyperlipidemia
  • hypertension
  • hypertriglyceridemia
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • immune reconstitution syndrome
  • infants
  • long QT syndrome
  • malnutrition
  • myocardial infarction
  • neonates
  • pregnancy
  • QT prolongation
  • serious rash
  • suicidal ideation
  • thyroid disease

Interactions

  • Abarelix
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Aclidinium; Formoterol
  • Adefovir
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfuzosin
  • Amiodarone
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Antacids
  • Apalutamide
  • Apomorphine
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Aripiprazole
  • Armodafinil
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atomoxetine
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azithromycin
  • Bedaquiline
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Bepridil
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  • Bismuth Subsalicylate; Metronidazole; Tetracycline
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  • Buprenorphine; Naloxone
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  • Calcium Carbonate; Simethicone
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  • Dextromethorphan; Quinidine
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  • Eliglustat
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  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Encorafenib
  • Enflurane
  • Entrectinib
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  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
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  • Esomeprazole; Naproxen
  • Etravirine
  • Ezogabine
  • Famotidine
  • Famotidine; Ibuprofen
  • Fedratinib
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  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flutamide
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • food
  • Formoterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Foscarnet
  • Fosphenytoin
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  • Gemtuzumab Ozogamicin
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  • grapefruit juice
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  • Peginterferon Alfa-2b
  • Peginterferon beta-1a
  • Pentamidine
  • Pentobarbital
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenobarbital
  • Phentermine; Topiramate
  • Phenylephrine; Promethazine
  • Phenytoin
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  • Verapamil
  • Voriconazole
  • Vorinostat
  • Zafirlukast
  • Ziprasidone
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