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What is RimabotulinumtoxinB
RimabotulinumtoxinB (formerly known as botulinum toxin type B) is a botulinum toxin produced from fermentation of Clostridium botulinum type B.
RimabotulinumtoxinB is approved for treating cervical dystonia and chronic sialorrhea in adults.
It decreases the severity of abnormal head position and neck pain in patients with cervical dystonia, and it has been found effective in patients with cervical dystonia who do and do not respond to type A.
RimabotuliniumtoxinB significantly decreased salivary flow rate among patients with various neurologic disorders including Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and stroke.
Spread of the toxin effect beyond the injection site may occur with use which can produce swallowing and breathing difficulties.
Brand Name
Myobloc
Indications
- cervical dystonia
- sialorrhea
Side Effects
- amblyopia
- angioedema
- antibody formation
- anxiety
- arthralgia
- asthenia
- back pain
- blurred vision
- chest pain (unspecified)
- chills
- confusion
- constipation
- cough
- cystitis
- dental caries
- diplopia
- distant spread of toxin effects
- dizziness
- drowsiness
- dysarthria
- dysgeusia
- dyspepsia
- dysphagia
- dysphonia
- dyspnea
- ecchymosis
- edema
- fever
- headache
- hypercholesterolemia
- hyperesthesia
- infection
- influenza
- injection site reaction
- malaise
- migraine
- musculoskeletal pain
- myasthenia
- peripheral edema
- peripheral vasodilation
- pruritus
- ptosis
- rash
- respiratory arrest
- rhinitis
- tinnitus
- torticollis
- tremor
- urinary incontinence
- urticaria
- vertigo
- visual impairment
- weakness
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- albumin hypersensitivity
- amyotrophic lateral sclerosis (ALS)
- autonomic neuropathy
- breast-feeding
- cerebral palsy
- children
- distant spread of toxin effects
- driving or operating machinery
- dysphagia
- geriatric
- infection
- inflammation
- myasthenia gravis
- myopathy
- neuromuscular disease
- pregnancy
- requires an experienced clinician
- respiratory insufficiency
- surgery
- viral infection
Interactions
- Amikacin
- Anticholinergics
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Atracurium
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Bacitracin
- Baclofen
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benztropine
- Capreomycin
- Capsaicin; Metaxalone
- Carisoprodol
- Chlordiazepoxide; Clidinium
- Chlorzoxazone
- Cisatracurium
- Cyclobenzaprine
- Dantrolene
- Dicyclomine
- Doxacurium
- Flavoxate
- Gentamicin
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Homatropine; Hydrocodone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Indacaterol; Glycopyrrolate
- Kanamycin
- Mepenzolate
- Metaxalone
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methscopolamine
- Mivacurium
- Neomycin
- Neuromuscular blockers
- OnabotulinumtoxinA
- Orphenadrine
- Oxybutynin
- Pancuronium
- Paromomycin
- Polymyxins
- Propantheline
- Rapacuronium
- Rocuronium
- Scopolamine
- Skeletal Muscle Relaxants
- Solifenacin
- Streptomycin
- Succinylcholine
- Tapentadol
- Tobramycin
- Trihexyphenidyl
- Trospium
- Tubocurarine
- Vecuronium
