Secretin

What is Secretin

Synthetic human or porcine secretin is a peptide hormone with amino acid sequences identical to naturally occurring secretin.

Secretin is indicated for the diagnosis of exocrine pancreas dysfunction or gastrinoma and for identifying the ampulla of Vater and accessory papilla during endoscopic retrograde cholangiopancreatography (ERCP). 

Brand Names

  • ChiRhoStim
  • SecreFlo

Indications

  • endoscopic retrograde cholangiopancreatography (ERCP)
  • exocrine pancreatic dysfunction diagnosis
  • gastrinoma diagnosis
  • pancreatic secretion stimulation

Side Effects

  • bradycardia
  • diaphoresis
  • flushing
  • hypotension
  • nausea
  • vomiting

Monitoring Parameters

  • intragastric pH
  • pancreatic function tests

Contraindications

  • alcoholism
  • anticholinergic medications
  • asthma
  • atopy
  • breast-feeding
  • eczema
  • geriatric
  • hepatic disease
  • inflammatory bowel disease
  • porcine protein hypersensitivity
  • pregnancy
  • vagotomy

Interactions

  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anticholinergics
  • Aspirin, ASA; Omeprazole
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Chlordiazepoxide; Clidinium
  • Cimetidine
  • Dexlansoprazole
  • Dicyclomine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Famotidine
  • Famotidine; Ibuprofen
  • Flavoxate
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • H2-blockers
  • Homatropine; Hydrocodone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indacaterol; Glycopyrrolate
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Mepenzolate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methscopolamine
  • Nizatidine
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oxybutynin
  • Pantoprazole
  • Propantheline
  • Proton pump inhibitors
  • Rabeprazole
  • Ranitidine
  • Scopolamine
  • Sincalide
  • Trihexyphenidyl
  • Trospium
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