Rh0 Immune Globulin

What is Rh0 Immune Globulin

Rh0 [D] immune globulin is a parenteral immune globulin used to prevent isoimmunization in Rh0 [D]-negative women exposed to Rh0 [D]-positive blood and thus, prevent the risk of erythroblastosis fetalis in current or subsequent pregnancies.

Rh0 [D] immune globulin is a solution containing IgG antibodies against erythrocyte antigen Rh0 [D]. 

Indications & Dosage

  • erythroblastosis fetalis prophylaxis
  • immune thrombocytopenic purpura (ITP)
  • Rh isoimmunization prophylaxis

For Rh isoimmunization prophylaxis in Rh0 [D]-negative patient and to ensure subsequent erythroblastosis fetalis prophylaxis in females with present and future pregnancies

Side Effects

  1. abdominal pain
  2. acute respiratory distress syndrome (ARDS)
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. anuria
  7. arthralgia
  8. asthenia
  9. back pain
  10. cardiac arrest
  11. chest pain (unspecified)
  12. chills
  13. diaphoresis
  14. diarrhea
  15. disseminated intravascular coagulation (DIC)
  16. dizziness
  17. drowsiness
  18. dyspnea
  19. ecchymosis
  20. edema
  21. erythema
  22. fever
  23. headache
  24. heart failure
  25. hematuria
  26. hemolysis
  27. hemolytic-uremic syndrome
  28. hyperbilirubinemia
  29. hyperhidrosis
  30. hyperkinesis
  31. hypertension
  32. hypotension
  33. hypoxia
  34. infection
  35. injection site reaction
  36. jaundice
  37. muscle cramps
  38. myalgia
  39. myocardial infarction
  40. nausea
  41. oliguria
  42. pallor
  43. peripheral vasodilation
  44. prolonged bleeding time
  45. pruritus
  46. pulmonary edema
  47. rash
  48. renal failure (unspecified)
  49. sinus tachycardia
  50. urticaria
  51. vomiting
  52. weakness
  53. weight gain
  54. wheezing

Monitoring Parameters

  • hemoglobin/hematocrit
  • platelet count
  • red blood cell count (RBC)
  • reticulocyte count
  • Rh serology
  • urinalysis

Contraindications

  • agammaglobulinemia
  • anemia
  • anticoagulant therapy
  • breast-feeding
  • children
  • coagulopathy
  • diabetes mellitus
  • geriatric
  • hemolysis
  • hemolytic anemia
  • hemophilia
  • hepatitis
  • hypogammaglobulinemia
  • IgA deficiency
  • infants
  • infection
  • intramuscular administration
  • intravenous administration
  • leukemia
  • lymphoma
  • neonates
  • pregnancy
  • renal impairment
  • requires a specialized care setting
  • systemic lupus erythematosus (SLE)
  • thrombocytopenia
  • vitamin K deficiency

Interactions

  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Tetanus Toxoid
  • Varicella-Zoster Virus Vaccine, Live
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