Rasagiline

What is Rasagiline

Rasagiline mesylate (Azilect) is a potent, second generation, irreversible monoamine oxidase inhibitor type B (MAO-B).

Rasagiline is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease as initial monotherapy (in early disease) and as adjunct therapy to levodopa (in later disease).

Brand Name

Azilect

Indications

  • Parkinson’s disease

For the treatment of Parkinson’s disease

as monotherapy or as adjunct therapy in patients not taking levodopa

Side Effects

  1. abdominal pain
  2. agitation
  3. amenorrhea
  4. anemia
  5. anorexia
  6. anuria
  7. anxiety
  8. aphasia
  9. apnea
  10. arthralgia
  11. arthropathy
  12. asthenia
  13. ataxia
  14. atopic dermatitis
  15. AV block
  16. bleeding
  17. blepharitis
  18. bundle-branch block
  19. chills
  20. colitis
  21. conjunctivitis
  22. constipation
  23. cough
  24. delirium
  25. depression
  26. diarrhea
  27. diplopia
  28. drowsiness
  29. dysarthria
  30. dysesthesia
  31. dysgeusia
  32. dyskinesia
  33. dysmenorrhea
  34. dyspepsia
  35. dyspnea
  36. dystonic reaction
  37. dysuria
  38. ecchymosis
  39. edema
  40. ejaculation dysfunction
  41. emotional lability
  42. epididymitis
  43. esophageal ulceration
  44. esophagitis
  45. exfoliative dermatitis
  46. fecal incontinence
  47. fever
  48. flank pain
  49. gastritis
  50. GI bleeding
  51. GI obstruction
  52. GI perforation
  53. gingivitis
  54. gynecomastia
  55. hallucinations
  56. headache
  57. hearing loss
  58. heart failure
  59. hematemesis
  60. hematuria
  61. hostility
  62. hyperesthesia
  63. hyperhidrosis
  64. hyperkinesis
  65. hypertension
  66. hypertensive crisis
  67. hypertonia
  68. hypocalcemia
  69. impulse control symptoms
  70. infection
  71. influenza
  72. involuntary movements
  73. jaundice
  74. keratitis
  75. laryngeal edema
  76. laryngospasm
  77. leukorrhea
  78. malaise
  79. mania
  80. melena
  81. memory impairment
  82. migraine
  83. myasthenia
  84. myelitis
  85. myocardial infarction
  86. myoclonia
  87. nausea
  88. nephrolithiasis
  89. neuritis
  90. neuroleptic malignant syndrome-like symptoms
  91. neuropathic pain
  92. nocturia
  93. ocular hemorrhage
  94. ocular pain
  95. oral ulceration
  96. orthostatic hypotension
  97. osteonecrosis
  98. paranoia
  99. paresthesias
  100. parosmia
  101. peptic ulcer
  102. phlebitis
  103. photophobia
  104. photosensitivity
  105. pleural effusion
  106. pneumothorax
  107. polyuria
  108. priapism
  109. psychosis
  110. ptosis
  111. pulmonary fibrosis
  112. purpura
  113. rash
  114. renal failure (unspecified)
  115. retinal detachment
  116. retinal hemorrhage
  117. rhinitis
  118. seizures
  119. serotonin syndrome
  120. stomatitis
  121. synovitis
  122. testicular swelling
  123. thrombosis
  124. toxic megacolon
  125. tremor
  126. urinary incontinence
  127. urinary retention
  128. urticaria
  129. vaginal bleeding
  130. vaginitis
  131. ventricular fibrillation
  132. ventricular tachycardia
  133. vertigo
  134. visual impairment
  135. vomiting
  136. weight loss
  137. xerostomia

Monitoring Parameters

  • LFTs
  • neurologic function

Contraindications

  • abrupt discontinuation
  • alcoholism
  • breast-feeding
  • cerebrovascular disease
  • children
  • coadministration with other CNS depressants
  • dental work
  • driving or operating machinery
  • ethanol ingestion
  • geriatric
  • hepatic disease
  • hypertension
  • hypertensive crisis
  • impulse control symptoms
  • infants
  • MAOI therapy
  • melanoma
  • orthostatic hypotension
  • pregnancy
  • psychosis
  • renal failure
  • renal impairment
  • schizophrenia
  • surgery

Interactions

  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Almotriptan
  • Alpha-blockers
  • Alprazolam
  • Altretamine
  • Ambrisentan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Anagrelide
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Aripiprazole
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Azilsartan
  • Azilsartan; Chlorthalidone
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Beta-adrenergic blockers
  • Beta-agonists
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Brexpiprazole
  • Brimonidine
  • Brimonidine; Brinzolamide
  • Brimonidine; Timolol
  • Brompheniramine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Bupropion
  • Bupropion; Naltrexone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Candesartan
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capmatinib
  • Captopril
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Central-acting adrenergic agents
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexbrompheniramine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloral Hydrate
  • Chlorcyclizine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Cimetidine
  • Ciprofloxacin
  • Clemastine
  • Clevidipine
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclizine
  • Cyclobenzaprine
  • Cyproheptadine
  • Deferasirox
  • Desloratadine; Pseudoephedrine
  • Desvenlafaxine
  • Deutetrabenazine
  • Dexchlorpheniramine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Diazoxide
  • Diethylpropion
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Dimenhydrinate
  • Diphenhydramine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Disulfiram
  • Dobutamine
  • Dopamine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxylamine
  • Doxylamine; Pyridoxine
  • Dronabinol
  • Droperidol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Eletriptan
  • Enalapril, Enalaprilat
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Ephedrine
  • Epinephrine
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Esketamine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etomidate
  • Famotidine
  • Famotidine; Ibuprofen
  • Felodipine
  • Fenoldopam
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • food
  • Fosinopril
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Frovatriptan
  • Furosemide
  • Gabapentin
  • General anesthetics
  • Granisetron
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Guanfacine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydralazine
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxyzine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Irbesartan
  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Isradipine
  • Ketamine
  • Labetalol
  • Lasmiditan
  • Lemborexant
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levodopa
  • Levomilnacipran
  • Levorphanol
  • Linezolid
  • Lisdexamfetamine
  • Lisinopril
  • Loop diuretics
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Losartan
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Mepivacaine; Levonordefrin
  • Meprobamate
  • Mesoridazine
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methohexital
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylphenidate
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Mexiletine
  • Midazolam
  • Midodrine
  • Milnacipran
  • Minoxidil
  • Mirtazapine
  • Moexipril
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Naratriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitroprusside
  • Norepinephrine
  • Norfloxacin
  • Obeticholic Acid
  • Olanzapine
  • Olmesartan
  • Osilodrostat
  • Oxazepam
  • Oxycodone
  • Oxymetazoline
  • Ozanimod
  • Paliperidone
  • Peginterferon Alfa-2b
  • Pemoline
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perindopril
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenobarbital
  • Phenothiazines
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pimozide
  • Pindolol
  • Potassium-sparing diuretics
  • Prazosin
  • Pregabalin
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Propranolol
  • Pseudoephedrine
  • Quazepam
  • Quetiapine
  • Quinapril
  • Racepinephrine
  • Ramelteon
  • Ramipril
  • Remifentanil
  • Reserpine
  • Risperidone
  • Ritodrine
  • Rizatriptan
  • Rucaparib
  • Sacubitril; Valsartan
  • Safinamide
  • Secobarbital
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Selective norepinephrine reuptake inhibitors
  • Selective serotonin reuptake inhibitors
  • Serotonin norepinephrine reuptake inhibitors
  • Sevoflurane
  • Sibutramine
  • Sildenafil
  • Simeprevir
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sumatriptan
  • Sympathomimetics
  • Tacrine
  • Tapentadol
  • Tedizolid
  • Telmisartan
  • Temazepam
  • Terazosin
  • Teriflunomide
  • Tetrabenazine
  • Tetrahydrozoline
  • Thiabendazole
  • Thiazide diuretics
  • Thiethylperazine
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Ticlopidine
  • Timolol
  • Tolcapone
  • Torsemide
  • Tramadol
  • Trandolapril
  • Trandolapril; Verapamil
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Tricyclic antidepressants
  • Trifluoperazine
  • Triprolidine
  • Trospium
  • Valbenazine
  • Valerian, Valeriana officinalis
  • Valsartan
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vortioxetine
  • Yohimbine
  • Zafirlukast
  • Zaleplon
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
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