Rapacuronium

What is Rapacuronium

NOTE: This drug is discontinued in the US.

Rapacuronium is a short-acting, nondepolarizing, neuromuscular blocking agent.

It was originally approved for use as an adjunct to general anesthesia, for endotracheal intubation, and for neuromuscular blockade during short surgical procedures.

Brand Name

Raplon

Indications & Dosage

  • endotracheal intubation
  • neuromuscular blockade

Side Effects

  1. anaphylactoid reactions
  2. angioedema
  3. apnea
  4. atrial fibrillation
  5. bradycardia
  6. bronchospasm
  7. dyspnea
  8. erythema
  9. flushing
  10. hypertension
  11. hypotension
  12. increased intracranial pressure
  13. malignant hyperthermia
  14. muscle paralysis
  15. nausea
  16. pruritus
  17. rash
  18. respiratory depression
  19. sinus tachycardia
  20. urticaria
  21. ventricular fibrillation
  22. ventricular tachycardia
  23. vomiting

Monitoring Parameters

  • arterial blood gases (ABGs)
  • peripheral nerve stimulation
  • serum electrolytes
  • serum magnesium

Contraindications

  • acid/base imbalance
  • asthma
  • breast-feeding
  • bromide hypersensitivity
  • burns
  • cardiac disease
  • cerebral palsy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • corticosteroid therapy
  • dehydration
  • electrolyte imbalance
  • geriatric
  • head trauma
  • hepatic disease
  • hypermagnesemia
  • hypocalcemia
  • hypokalemia
  • hyponatremia
  • increased intracranial pressure
  • infants
  • lung cancer
  • malignant hyperthermia
  • metabolic alkalosis
  • myasthenia gravis
  • myopathy
  • neonates
  • neuromuscular blocking agent hypersensitivity
  • neuromuscular disease
  • obesity
  • pregnancy
  • pulmonary disease
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis
  • respiratory depression
  • surgery
  • trauma

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Amide local anesthetics
  • Aminoglycosides
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amphotericin B
  • Amphotericin B cholesteryl sulfate complex (ABCD)
  • Amphotericin B lipid complex (ABLC)
  • Amphotericin B liposomal (LAmB)
  • Apomorphine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Bacitracin
  • Belladonna; Opium
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzonatate
  • Beta-blockers
  • Betaxolol
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Botulinum Toxins
  • Brimonidine; Timolol
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Calcium
  • Calcium Acetate
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Calcium Chloride
  • Calcium Gluconate
  • Calcium-channel blockers
  • Calcium; Vitamin D
  • Capreomycin
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carteolol
  • Carvedilol
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chromium
  • Clevidipine
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colistimethate, Colistin, Polymyxin E
  • Corticosteroids
  • Cyclosporine
  • Demeclocycline
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dorzolamide; Timolol
  • Doxycycline
  • Enalapril; Felodipine
  • Esmolol
  • Ester local anesthetics
  • Felodipine
  • Fentanyl
  • Fosphenytoin
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Hetastarch; Dextrose; Electrolytes
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Indapamide
  • Isradipine
  • Labetalol
  • Levobetaxolol
  • Levobunolol
  • Levomethadyl
  • Levorphanol
  • Lincosamides
  • Lithium
  • Loop diuretics
  • Magnesium
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methohexital
  • Metoprolol
  • Minocycline
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nalbuphine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nicardipine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Omadacycline
  • Oxycodone
  • Oxymorphone
  • Penbutolol
  • Perindopril; Amlodipine
  • Phenylephrine; Promethazine
  • Phenytoin
  • Pindolol
  • Polymyxin B
  • Polymyxins
  • Procainamide
  • Promethazine
  • Propoxyphene
  • Propranolol
  • Quinidine
  • Quinine
  • Remifentanil
  • Sarecycline
  • Sedating H1-blockers
  • Skeletal Muscle Relaxants
  • Sotalol
  • Sufentanil
  • Tapentadol
  • Tetracycline
  • Tetracyclines
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiopental
  • Timolol
  • Trandolapril; Verapamil
  • Vancomycin
  • Verapamil
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