What is Rasburicase
Rasburicase catalyzes the enzymatic oxidation of uric acid to the inactive and more soluble metabolite, allantoin.
It is a recombinant form of urate oxidase produced by cloning the gene for Aspergillus flavus urate oxidase for expression in Saccharomyces cerevisiae.
Rasburicase is indicated for the initial management of plasma uric acid levels in pediatric and adult patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anticancer therapy expected to result in tumor lysis and subsequent elevation of plasma uric acid.
Brand Name
Elitek
Indications & Dosage
- hyperuricemia
For the initial management of plasma uric acid levels in adult and pediatric patients with leukemia, lymphoma, and solid tumor malignancies who are receiving anti-cancer therapy expected to result in tumor lysis and elevation of plasma uric acid
NOTE: The FDA has designated rasburicase as an orphan drug for the treatment of malignancy-associated or chemotherapy-induced hyperuricemia.
Side Effects
- abdominal pain
- abdominal pain
- anaphylactic shock
- antibody formation
- anxiety
- anxiety
- arthralgia
- bleeding
- bronchospasm
- chest pain (unspecified)
- constipation
- diarrhea
- dyspnea
- edema
- edema
- elevated hepatic enzymes
- elevated hepatic enzymes
- fever
- headache
- hemolysis
- hyperbilirubinemia
- hyperbilirubinemia
- hyperphosphatemia
- hypophosphatemia
- hypophosphatemia
- hypotension
- hypoxia
- infection
- infection
- injection site reaction
- involuntary movements
- methemoglobinemia
- nausea
- nausea
- oral ulceration
- peripheral edema
- peripheral edema
- rash
- seizures
- serious hypersensitivity reactions or anaphylaxis
- supraventricular tachycardia (SVT)
- urticaria
- vomiting
- vomiting
Monitoring Parameters
- arterial blood gases (ABGs)
- CBC with differential
- LDH
- serum bilirubin
- serum creatinine
- serum electrolytes
- serum uric acid
Contraindications
- acute bronchospasm
- breast-feeding
- G6PD deficiency
- hemolytic anemia
- hypotension
- interference with uric acid measurements
- mannitol hypersensitivity
- methemoglobin reductase deficiency
- methemoglobinemia
- pregnancy
- serious hypersensitivity reactions or anaphylaxis
- shock
- urticaria
- yeast hypersensitivity
Interactions
- Articaine; Epinephrine
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Chloroprocaine
- Lidocaine
- Mepivacaine
- Mepivacaine; Levonordefrin
- Penicillin G Benzathine; Penicillin G Procaine
- Penicillin G Procaine
- Prilocaine
- Prilocaine; Epinephrine
- Ropivacaine
- Tetracaine
