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What is Rasagiline
Rasagiline mesylate (Azilect) is a potent, second generation, irreversible monoamine oxidase inhibitor type B (MAO-B).
Rasagiline is indicated for the treatment of the signs and symptoms of idiopathic Parkinson’s disease as initial monotherapy (in early disease) and as adjunct therapy to levodopa (in later disease).
Brand Name
Azilect
Indications
- Parkinson’s disease
For the treatment of Parkinson’s disease
as monotherapy or as adjunct therapy in patients not taking levodopa
Side Effects
- abdominal pain
- agitation
- amenorrhea
- anemia
- anorexia
- anuria
- anxiety
- aphasia
- apnea
- arthralgia
- arthropathy
- asthenia
- ataxia
- atopic dermatitis
- AV block
- bleeding
- blepharitis
- bundle-branch block
- chills
- colitis
- conjunctivitis
- constipation
- cough
- delirium
- depression
- diarrhea
- diplopia
- drowsiness
- dysarthria
- dysesthesia
- dysgeusia
- dyskinesia
- dysmenorrhea
- dyspepsia
- dyspnea
- dystonic reaction
- dysuria
- ecchymosis
- edema
- ejaculation dysfunction
- emotional lability
- epididymitis
- esophageal ulceration
- esophagitis
- exfoliative dermatitis
- fecal incontinence
- fever
- flank pain
- gastritis
- GI bleeding
- GI obstruction
- GI perforation
- gingivitis
- gynecomastia
- hallucinations
- headache
- hearing loss
- heart failure
- hematemesis
- hematuria
- hostility
- hyperesthesia
- hyperhidrosis
- hyperkinesis
- hypertension
- hypertensive crisis
- hypertonia
- hypocalcemia
- impulse control symptoms
- infection
- influenza
- involuntary movements
- jaundice
- keratitis
- laryngeal edema
- laryngospasm
- leukorrhea
- malaise
- mania
- melena
- memory impairment
- migraine
- myasthenia
- myelitis
- myocardial infarction
- myoclonia
- nausea
- nephrolithiasis
- neuritis
- neuroleptic malignant syndrome-like symptoms
- neuropathic pain
- nocturia
- ocular hemorrhage
- ocular pain
- oral ulceration
- orthostatic hypotension
- osteonecrosis
- paranoia
- paresthesias
- parosmia
- peptic ulcer
- phlebitis
- photophobia
- photosensitivity
- pleural effusion
- pneumothorax
- polyuria
- priapism
- psychosis
- ptosis
- pulmonary fibrosis
- purpura
- rash
- renal failure (unspecified)
- retinal detachment
- retinal hemorrhage
- rhinitis
- seizures
- serotonin syndrome
- stomatitis
- synovitis
- testicular swelling
- thrombosis
- toxic megacolon
- tremor
- urinary incontinence
- urinary retention
- urticaria
- vaginal bleeding
- vaginitis
- ventricular fibrillation
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight loss
- xerostomia
Monitoring Parameters
- LFTs
- neurologic function
Contraindications
- abrupt discontinuation
- alcoholism
- breast-feeding
- cerebrovascular disease
- children
- coadministration with other CNS depressants
- dental work
- driving or operating machinery
- ethanol ingestion
- geriatric
- hepatic disease
- hypertension
- hypertensive crisis
- impulse control symptoms
- infants
- MAOI therapy
- melanoma
- orthostatic hypotension
- pregnancy
- psychosis
- renal failure
- renal impairment
- schizophrenia
- surgery
Interactions
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Diphenhydramine
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alpha-blockers
- Alprazolam
- Altretamine
- Ambrisentan
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Anagrelide
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Anticholinergics
- Anxiolytics; Sedatives; and Hypnotics
- Aripiprazole
- Articaine; Epinephrine
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azilsartan
- Azilsartan; Chlorthalidone
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Beta-adrenergic blockers
- Beta-agonists
- Betaxolol
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Bosentan
- Brexpiprazole
- Brimonidine
- Brimonidine; Brinzolamide
- Brimonidine; Timolol
- Brompheniramine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Dextromethorphan; Guaifenesin
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Buprenorphine
- Buprenorphine; Naloxone
- Bupropion
- Bupropion; Naltrexone
- Buspirone
- Butabarbital
- Butorphanol
- Caffeine
- Caffeine; Ergotamine
- Calcium-channel blockers
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Cannabidiol
- Capmatinib
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbetapentane; Pyrilamine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Cenobamate
- Central-acting adrenergic agents
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexbrompheniramine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloral Hydrate
- Chlorcyclizine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chlorothiazide
- Chlorpheniramine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorpromazine
- Chlorthalidone
- Chlorthalidone; Clonidine
- Cimetidine
- Ciprofloxacin
- Clemastine
- Clevidipine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Cyclizine
- Cyclobenzaprine
- Cyproheptadine
- Deferasirox
- Desloratadine; Pseudoephedrine
- Desvenlafaxine
- Deutetrabenazine
- Dexchlorpheniramine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Diethylpropion
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diltiazem
- Dimenhydrinate
- Diphenhydramine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disulfiram
- Dobutamine
- Dopamine
- Dorzolamide; Timolol
- Doxazosin
- Doxylamine
- Doxylamine; Pyridoxine
- Dronabinol
- Droperidol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Eletriptan
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Entacapone
- Ephedrine
- Epinephrine
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Esketamine
- Esmolol
- Estazolam
- Eszopiclone
- Ethacrynic Acid
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Etomidate
- Famotidine
- Famotidine; Ibuprofen
- Felodipine
- Fenoldopam
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fluoxetine; Olanzapine
- Fluphenazine
- Flurazepam
- food
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fospropofol
- Frovatriptan
- Furosemide
- Gabapentin
- General anesthetics
- Granisetron
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanabenz
- Guanfacine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Methyldopa
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hydroxyzine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Iloperidone
- Iloprost
- Irbesartan
- Isoflurane
- Isoniazid, INH
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isradipine
- Ketamine
- Labetalol
- Lasmiditan
- Lemborexant
- Levobetaxolol
- Levobunolol
- Levocetirizine
- Levodopa
- Levomilnacipran
- Levorphanol
- Linezolid
- Lisdexamfetamine
- Lisinopril
- Loop diuretics
- Loratadine; Pseudoephedrine
- Lorazepam
- Losartan
- Loxapine
- Lumateperone
- Lurasidone
- Maprotiline
- Mecamylamine
- Meclizine
- Meperidine
- Meperidine; Promethazine
- Mephobarbital
- Mepivacaine; Levonordefrin
- Meprobamate
- Mesoridazine
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methohexital
- Methyclothiazide
- Methyldopa
- Methylene Blue
- Methylphenidate
- Metoclopramide
- Metolazone
- Metoprolol
- Mexiletine
- Midazolam
- Midodrine
- Milnacipran
- Minoxidil
- Mirtazapine
- Moexipril
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nadolol
- Nalbuphine
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Naratriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nicardipine
- Nifedipine
- Nimodipine
- Nisoldipine
- Nitroprusside
- Norepinephrine
- Norfloxacin
- Obeticholic Acid
- Olanzapine
- Olmesartan
- Osilodrostat
- Oxazepam
- Oxycodone
- Oxymetazoline
- Ozanimod
- Paliperidone
- Peginterferon Alfa-2b
- Pemoline
- Penbutolol
- Pentazocine
- Pentazocine; Naloxone
- Pentobarbital
- Perindopril
- Perindopril; Amlodipine
- Perphenazine
- Perphenazine; Amitriptyline
- Phendimetrazine
- Phenobarbital
- Phenothiazines
- Phenoxybenzamine
- Phentermine
- Phentermine; Topiramate
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Pimozide
- Pindolol
- Potassium-sparing diuretics
- Prazosin
- Pregabalin
- Prilocaine; Epinephrine
- Primidone
- Procarbazine
- Prochlorperazine
- Promethazine
- Propofol
- Propoxyphene
- Propranolol
- Pseudoephedrine
- Quazepam
- Quetiapine
- Quinapril
- Racepinephrine
- Ramelteon
- Ramipril
- Remifentanil
- Reserpine
- Risperidone
- Ritodrine
- Rizatriptan
- Rucaparib
- Sacubitril; Valsartan
- Safinamide
- Secobarbital
- Sedating H1-blockers
- Segesterone Acetate; Ethinyl Estradiol
- Selective norepinephrine reuptake inhibitors
- Selective serotonin reuptake inhibitors
- Serotonin norepinephrine reuptake inhibitors
- Sevoflurane
- Sibutramine
- Sildenafil
- Simeprevir
- Sodium Oxybate
- Solifenacin
- Solriamfetol
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sumatriptan
- Sympathomimetics
- Tacrine
- Tapentadol
- Tedizolid
- Telmisartan
- Temazepam
- Terazosin
- Teriflunomide
- Tetrabenazine
- Tetrahydrozoline
- Thiabendazole
- Thiazide diuretics
- Thiethylperazine
- Thiopental
- Thioridazine
- Thiothixene
- Ticlopidine
- Timolol
- Tolcapone
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Trazodone
- Treprostinil
- Triamterene
- Triazolam
- Tricyclic antidepressants
- Trifluoperazine
- Triprolidine
- Trospium
- Valbenazine
- Valerian, Valeriana officinalis
- Valsartan
- Vemurafenib
- Venlafaxine
- Verapamil
- Vilazodone
- Vortioxetine
- Yohimbine
- Zafirlukast
- Zaleplon
- Zileuton
- Ziprasidone
- Zolmitriptan
- Zolpidem
