Clobazam Brand Names- ONFI | Sympazan
What is Clobazam
Clobazam is a benzodiazepine derivative anticonvulsant medication FDA-approved for the adjunct treatment of seizures associated with Lennox-Gastaut syndrome in patients 2 years and older.
Similar to other benzodiazepines, clobazam has the potential for psychological and physical dependence and is classified as a controlled substance.
Indications
- Dravet syndrome
- Lennox-Gastaut syndrome
For the adjunct treatment of seizures associated with Lennox-Gastaut syndrome
NOTE: Clobazam has been designated an orphan drug for this indication by the FDA.
Side Effects
- agitation
- anemia
- angioedema
- anorexia
- anxiety
- appetite stimulation
- ataxia
- blurred vision
- confusion
- constipation
- cough
- delirium
- depression
- diplopia
- drowsiness
- dysarthria
- dysphagia
- edema
- elevated hepatic enzymes
- eosinophilia
- fatigue
- fever
- hallucinations
- hypothermia
- infection
- infertility
- insomnia
- irritability
- lethargy
- leukopenia
- muscle cramps
- physiological dependence
- psychological dependence
- rash
- respiratory depression
- restlessness
- Stevens-Johnson syndrome
- suicidal ideation
- teratogenesis
- thrombocytopenia
- toxic epidermal necrolysis
- urinary retention
- urticaria
- vomiting
- withdrawal
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- abrupt discontinuation
- alcoholism
- benzodiazepine hypersensitivity
- breast-feeding
- coadministration with other CNS depressants
- depression
- dialysis
- driving or operating machinery
- ethanol ingestion
- ethanol intoxication
- geriatric
- hepatic disease
- infertility
- labor
- obstetric delivery
- poor metabolizers
- pregnancy
- renal failure
- renal impairment
- reproductive risk
- respiratory depression
- substance abuse
- suicidal ideation
Interactions
- Abacavir; Dolutegravir; Lamivudine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan
- Acetaminophen; Dextromethorphan; Doxylamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Tramadol
- Alfentanil
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Alprazolam
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- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
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- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amoxapine
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamines
- Anxiolytics; Sedatives; and Hypnotics
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
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- Atazanavir; Cobicistat
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- Cevimeline
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- Chlordiazepoxide; Clidinium
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- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
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- Codeine; Promethazine
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- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
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- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dextroamphetamine
- Dextromethorphan
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Promethazine
- Dextromethorphan; Quinidine
- Diazepam
- Dienogest; Estradiol valerate
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- Dolutegravir
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