Clobazam

Clobazam Brand Names- ONFI | Sympazan

What is Clobazam

Clobazam is a benzodiazepine derivative anticonvulsant medication FDA-approved for the adjunct treatment of seizures associated with Lennox-Gastaut syndrome in patients 2 years and older.

Similar to other benzodiazepines, clobazam has the potential for psychological and physical dependence and is classified as a controlled substance.

Indications

  • Dravet syndrome
  • Lennox-Gastaut syndrome

For the adjunct treatment of seizures associated with Lennox-Gastaut syndrome

NOTE: Clobazam has been designated an orphan drug for this indication by the FDA.

Side Effects

  1. agitation
  2. anemia
  3. angioedema
  4. anorexia
  5. anxiety
  6. appetite stimulation
  7. ataxia
  8. blurred vision
  9. confusion
  10. constipation
  11. cough
  12. delirium
  13. depression
  14. diplopia
  15. drowsiness
  16. dysarthria
  17. dysphagia
  18. edema
  19. elevated hepatic enzymes
  20. eosinophilia
  21. fatigue
  22. fever
  23. hallucinations
  24. hypothermia
  25. infection
  26. infertility
  27. insomnia
  28. irritability
  29. lethargy
  30. leukopenia
  31. muscle cramps
  32. physiological dependence
  33. psychological dependence
  34. rash
  35. respiratory depression
  36. restlessness
  37. Stevens-Johnson syndrome
  38. suicidal ideation
  39. teratogenesis
  40. thrombocytopenia
  41. toxic epidermal necrolysis
  42. urinary retention
  43. urticaria
  44. vomiting
  45. withdrawal

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • abrupt discontinuation
  • alcoholism
  • benzodiazepine hypersensitivity
  • breast-feeding
  • coadministration with other CNS depressants
  • depression
  • dialysis
  • driving or operating machinery
  • ethanol ingestion
  • ethanol intoxication
  • geriatric
  • hepatic disease
  • infertility
  • labor
  • obstetric delivery
  • poor metabolizers
  • pregnancy
  • renal failure
  • renal impairment
  • reproductive risk
  • respiratory depression
  • substance abuse
  • suicidal ideation

Interactions

  • Abacavir; Dolutegravir; Lamivudine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Tramadol
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Alprazolam
  • Amitriptyline
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamines
  • Anxiolytics; Sedatives; and Hypnotics
  • Aprepitant, Fosaprepitant
  • Aripiprazole
  • Armodafinil
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • atypical antipsychotic
  • Barbiturates
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzphetamine
  • Brexpiprazole
  • Brompheniramine; Dextromethorphan; Guaifenesin
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Carbamazepine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Cariprazine
  • Cenobamate
  • Cevimeline
  • Chloramphenicol
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Cimetidine
  • Clomipramine
  • Clonazepam
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colesevelam
  • Conjugated Estrogens
  • Conjugated Estrogens; Bazedoxifene
  • Conjugated Estrogens; Medroxyprogesterone
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Delavirdine
  • Desipramine
  • Deutetrabenazine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dextroamphetamine
  • Dextromethorphan
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dienogest; Estradiol valerate
  • Diethylstilbestrol, DES
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dolutegravir
  • Dolutegravir; Lamivudine
  • Dolutegravir; Rilpivirine
  • Doravirine
  • Doravirine; Lamivudine; Tenofovir disoproxil fumarate
  • Doxepin
  • Doxorubicin
  • Dronabinol
  • Droperidol
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enflurane
  • Entacapone
  • Eslicarbazepine
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estazolam
  • Esterified Estrogens
  • Esterified Estrogens; Methyltestosterone
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Estradiol; Progesterone
  • Estramustine
  • Estropipate
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etomidate
  • Etonogestrel
  • Etravirine
  • Fedratinib
  • Felbamate
  • Fentanyl
  • Flecainide
  • Fluconazole
  • Flumazenil
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurazepam
  • Fluvoxamine
  • Fosphenytoin
  • Fospropofol
  • Gabapentin
  • General anesthetics
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hydroxychloroquine
  • Hydroxyprogesterone
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Iloperidone
  • Imipramine
  • Isavuconazonium
  • Isoflurane
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Ketamine
  • Ketoconazole
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lemborexant
  • Letermovir
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Levorphanol
  • Lisdexamfetamine
  • Lofexidine
  • Lopinavir; Ritonavir
  • Lorazepam
  • Loxapine
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Lumateperone
  • Lurasidone
  • Maprotiline
  • Maraviroc
  • Medroxyprogesterone
  • Meperidine
  • Meperidine; Promethazine
  • Mestranol; Norethindrone
  • Methadone
  • Methamphetamine
  • Mexiletine
  • Midazolam
  • Modafinil
  • Molindone
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nanoparticle Albumin-Bound Paclitaxel
  • Nicardipine
  • Nisoldipine
  • Norethindrone
  • Norgestrel
  • Nortriptyline
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Oxazepam
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Pentazocine
  • Pentazocine; Naloxone
  • Perindopril; Amlodipine
  • Perphenazine; Amitriptyline
  • Phenothiazines
  • Phenytoin
  • Pimozide
  • Pramipexole
  • Praziquantel
  • Pregabalin
  • Progesterone
  • Propafenone
  • Propofol
  • Propranolol
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Quinine
  • Rabeprazole
  • Remifentanil
  • Risperidone
  • Ritonavir
  • Ropinirole
  • Sedating H1-blockers
  • Segesterone Acetate; Ethinyl Estradiol
  • Sevoflurane
  • Sodium Oxybate
  • Sufentanil
  • Tapentadol
  • Temazepam
  • Thiothixene
  • Ticlopidine
  • Tolcapone
  • Tramadol
  • Triazolam
  • Tricyclic antidepressants
  • Trimipramine
  • Ubrogepant
  • Ulipristal
  • Valerian, Valeriana officinalis
  • Ziprasidone
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