Clobetasol

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Clobetasol Brand Names

Clobevate | Clobex | Clodan | Cormax | Embeline | Embeline E | Impoyz | Olux | Olux-E | Olux-Olux-E Complete Pack | Temovate | Temovate E

What is Clobetasol

Clobetasol is a topical, synthetic fluorinated corticosteroid.

Clobetasol is used to relieve the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses and psoriasis.

Clobetasol is one of the most potent topical corticosteroids, and is usually recommended for short-term or cyclic therapy only.

Very high potency topical corticosteroids are used as an alternative to systemic therapy for localized conditions.

Long-term use can lead to systemic side effects, including hypothalamic-pituitary-adrenal (HPA) axis suppression.

Clobetasol was first approved by the FDA in 1985.

Indications

  1. alopecia
  2. aphthous ulcer
  3. atopic dermatitis
  4. contact dermatitis
  5. discoid lupus erythematosus
  6. eczema
  7. erythema multiforme
  8. exfoliative dermatitis
  9. granuloma annulare
  10. hemangioma
  11. keloids
  12. lichen planus
  13. lichen sclerosus
  14. lichen simplex
  15. lichen striatus
  16. necrobiosis lipoidica diabeticorum
  17. pemphigus
  18. pityriasis rosea
  19. psoriasis
  20. Rhus dermatitis
  21. sarcoidosis
  22. urticaria

Side Effects

  1. acneiform rash
  2. adrenocortical insufficiency
  3. alopecia
  4. cataracts
  5. contact dermatitis
  6. Cushing’s syndrome
  7. erythema
  8. folliculitis
  9. glycosuria
  10. growth inhibition
  11. headache
  12. hyperglycemia
  13. hypertension
  14. hypertrichosis
  15. hypothalamic-pituitary-adrenal (HPA) suppression
  16. impaired wound healing
  17. increased intracranial pressure
  18. infection
  19. maculopapular rash
  20. miliaria
  21. ocular hypertension
  22. ocular irritation
  23. papilledema
  24. pruritus
  25. pseudotumor cerebri
  26. retinopathy
  27. skin atrophy
  28. skin hypopigmentation
  29. skin irritation
  30. skin ulcer
  31. striae
  32. telangiectasia
  33. tolerance
  34. vesicular rash
  35. visual impairment
  36. withdrawal
  37. xerosis

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acne rosacea
  • acne vulgaris
  • breast-feeding
  • cataracts
  • children
  • corticosteroid hypersensitivity
  • Cushing’s syndrome
  • diabetes mellitus
  • fungal infection
  • geriatric
  • glaucoma
  • growth inhibition
  • hepatic disease
  • herpes infection
  • hypothalamic-pituitary-adrenal (HPA) suppression
  • increased intracranial pressure
  • infants
  • infection
  • measles
  • neonates
  • occlusive dressing
  • ocular exposure
  • perioral dermatitis
  • peripheral vascular disease
  • pregnancy
  • skin abrasion
  • skin atrophy
  • tobacco smoking
  • varicella
  • viral infection

Interactions

  • Deferasirox
  • Metyrapone

Deferasirox: (Moderate) Because gastric ulceration and GI bleeding have been reported in patients taking deferasirox, use caution when coadministering with other drugs known to increase the risk of peptic ulcers or gastric hemorrhage including corticosteroids. 

Metyrapone: (Major) Medications which affect pituitary or adrenocortical function, including all corticosteroid therapy, should be discontinued prior to and during testing with metyrapone.

Patients taking inadvertent doses of corticosteroids on the test day may exhibit abnormally high basal plasma cortisol levels and a decreased response to the test. Although systemic absorption of topical corticosteroids is minimal, temporary discontinuation of these products should be considered if possible to reduce the potential for interference with the test results.

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