Clevidipine

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Clevidipine Brand Name– Cleviprex

What is Clevidipine

Clevidipine is an injectable short-acting dihydropyridine L-type calcium channel blocker used for the treatment of hypertension.

The injectable emulsion is administered via continuous IV infusion; it has a very quick onset and short duration of action allowing for rapid dose titration (see Pharmacokinetics).

Relatively few drugs are available for the control of blood pressure before, during, and after a surgical procedure (e.g., nitroprusside, nitroglycerin, nicardipine), and most are longer-acting than clevidipine and associated with potentially dangerous toxicities (e.g., nitroprusside).

In August 2008, clevidipine was approved by the FDA for the reduction of blood pressure when oral therapy is not feasible or desirable.

Indications

  • hypertension

Side Effects

  1. atrial fibrillation
  2. cardiac arrest
  3. dyspnea
  4. headache
  5. hypotension
  6. myocardial infarction
  7. nausea
  8. renal failure (unspecified)
  9. sinus tachycardia
  10. syncope
  11. vomiting

Monitoring Parameters

  • blood pressure
  • heart rate

Contraindications

  • aortic stenosis
  • breast-feeding
  • children
  • egg hypersensitivity
  • geriatric
  • heart failure
  • hyperlipidemia
  • hypertension
  • infants
  • labor
  • neonates
  • obstetric delivery
  • pancreatitis
  • pheochromocytoma
  • pregnancy
  • soya lecithin hypersensitivity

Interactions

  • Acebutolol
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alfentanil
  • Alprostadil
  • Amifostine
  • Aminolevulinic Acid
  • Amlodipine; Celecoxib
  • Amphetamine; Dextroamphetamine Salts
  • Amyl Nitrite
  • Apomorphine
  • Apraclonidine
  • Asenapine
  • Atenolol
  • Atenolol; Chlorthalidone
  • Baclofen
  • Bendroflumethiazide; Nadolol
  • Benzonatate
  • Benzphetamine
  • Beta-blockers
  • Betaxolol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bortezomib
  • Brimonidine; Timolol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cariprazine
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Co-Enzyme Q10, Ubiquinone
  • Cocaine
  • Codeine; Phenylephrine; Promethazine
  • Danazol
  • Dantrolene
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diethylpropion
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dorzolamide; Timolol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Ephedrine
  • Epirubicin
  • Epoprostenol
  • Ergonovine
  • Esmolol
  • Esomeprazole; Naproxen
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Etodolac
  • Etomidate
  • Famotidine; Ibuprofen
  • Fenoprofen
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Fospropofol
  • General anesthetics
  • Ginkgo, Ginkgo biloba
  • Ginseng, Panax ginseng
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Halothane
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Indomethacin
  • Intravenous Lipid Emulsions
  • Isocarboxazid
  • Isoflurane
  • Isoproterenol
  • Isosorbide Dinitrate, ISDN
  • Isosorbide Mononitrate
  • Ketamine
  • Ketoprofen
  • Ketorolac
  • Labetalol
  • Lacosamide
  • Lanreotide
  • Lansoprazole; Naproxen
  • Lasmiditan
  • Levobetaxolol
  • Levobunolol
  • Levodopa
  • Lisdexamfetamine
  • Lithium
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Lovastatin; Niacin
  • Lurasidone
  • Meclofenamate Sodium
  • Mefenamic Acid
  • Melatonin
  • Meloxicam
  • Mestranol; Norethindrone
  • Methamphetamine
  • Methoxsalen
  • Methylphenidate
  • Methysergide
  • Metoprolol
  • Milrinone
  • Nabumetone
  • Nadolol
  • Naproxen
  • Naproxen; Pseudoephedrine
  • Naproxen; Sumatriptan
  • Nebivolol
  • Nebivolol; Valsartan
  • Nesiritide, BNP
  • Neuromuscular blockers
  • Nevirapine
  • Niacin, Niacinamide
  • Niacin; Simvastatin
  • Nitrates
  • Nitroglycerin
  • Nitroprusside
  • Nonsteroidal antiinflammatory drugs
  • Octreotide
  • Olanzapine
  • Ombitasvir; Paritaprevir; Ritonavir
  • Oxaprozin
  • Oxymetazoline
  • Paliperidone
  • Pasireotide
  • Penbutolol
  • Pentoxifylline
  • Phenelzine
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Photosensitizing agents (topical)
  • Pindolol
  • Piroxicam
  • Prazosin
  • Procainamide
  • Procaine
  • Propofol
  • Propranolol
  • Pseudoephedrine
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Ritonavir
  • Rofecoxib
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sevoflurane
  • Sincalide
  • Sotalol
  • Sufentanil
  • Sulindac
  • Tamsulosin
  • Temsirolimus
  • Tetrabenazine
  • Tetracaine
  • Thalidomide
  • Thiothixene
  • Timolol
  • Tolmetin
  • Tranylcypromine
  • Trazodone
  • Valdecoxib
  • Verteporfin
  • Yohimbine

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