Carbetapentane Guaifenesin

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Carbetapentane Guaifenesin Brand Names

AllFen C | AllFen CX | Allres-G | Ambi | Betavent | Carba XP | Certuss | Duratuss CS | Dynex VR | Exall | Expectuss | Oratuss | Pulmari GP | Respi-TANN G | Tusso-ZMR | Tusso-ZR | Xpect-AT

What is Carbetapentane Guaifenesin

Carbetapentane guaifenesin is an antitussive-expectorant combination product.

Guaifenesin, an oral expectorant, is commonly used to treat cough due to colds and minor upper respiratory infections. Despite its long history of use since the 1950’s, the efficacy of guaifenesin has only recently been substantiated.

Although guaifenesin may be used as an expectorant in both productive and non-productive coughs, it is especially useful in the treatment of dry, non-productive coughs which tend to injure the respiratory mucous membranes.

Carbetapentane is a non-opioid, centrally acting cough suppressant. The antitussive effect of carbetapentane is less potent than that of opiates. However, unlike opiates, carbetapentane has not been associated with substance abuse.

Carbetapentane guaifenesin products are available by prescription only.

Indications

  • bronchitis
  • common cold
  • cough

For the temporary relief of cough, especially non-productive cough, due to minor throat irritation and bronchial irritation as may occur with the common cold, influenza, sinusitis, bronchitis, or inhaled irritants

Side Effects

  1. abdominal pain
  2. apnea
  3. diarrhea
  4. dizziness
  5. drowsiness
  6. headache
  7. hypotonia
  8. leukopenia
  9. nausea
  10. nephrolithiasis
  11. rash
  12. respiratory depression
  13. seizures
  14. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • breast-feeding
  • bronchitis
  • children
  • driving or operating machinery
  • emphysema
  • fever
  • geriatric
  • head trauma
  • headache
  • heart failure
  • hepatic disease
  • increased intracranial pressure
  • infants
  • MAOI therapy
  • neonates
  • pregnancy
  • seizure disorder
  • seizures
  • tobacco smoking
  • vomiting

Interactions

  • Acetaminophen; Tramadol
  • Amoxapine
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benztropine
  • Buspirone
  • Butyrophenone
  • Chlordiazepoxide; Clidinium
  • COMT inhibitors
  • Dicyclomine
  • Dronabinol
  • Ethanol
  • Flavoxate
  • General anesthetics
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Indacaterol; Glycopyrrolate
  • Isocarboxazid
  • Linezolid
  • Maprotiline
  • Mepenzolate
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methscopolamine
  • Minocycline
  • Molindone
  • Monoamine oxidase inhibitors
  • Nefazodone
  • Opiate Agonists
  • Opiate Agonists-Antagonists
  • Oxybutynin
  • Phenelzine
  • Phenothiazines
  • Pimozide
  • Pramipexole
  • Pregabalin
  • Propantheline
  • Ropinirole
  • Scopolamine
  • Sedating H1-blockers
  • Selegiline
  • Skeletal Muscle Relaxants
  • Tizanidine
  • Tramadol
  • Tranylcypromine
  • Tricyclic antidepressants
  • Trihexyphenidyl
  • Trospium

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