Clemastine

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Clemastine Brand Name– Dailyhist-1 | Tavist | Tavist Allergy

What is Clemastine

Clemastine is an ethanolamine class, first-generation sedating antihistamine (H1-blocker).

Clemastine has a longer duration of action than more commonly used first-generation antihistamines such as chlorpheniramine and diphenhydramine.

The drug is used to temporarily reduce symptoms of the common cold, seasonal allergies, and other respiratory allergies such as rhinorrhea, itchy, watery eyes, sneezing, and nasal and throat pruritus.

Clemastine was originally approved by the FDA in 1977 as a prescription-only drug and is now available without a prescription (OTC).

Indications

  1. allergic rhinitis
  2. angioedema
  3. common cold
  4. ocular pruritus
  5. pruritus
  6. rhinorrhea
  7. sneezing
  8. urticaria

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anorexia
  5. blurred vision
  6. chills
  7. confusion
  8. constipation
  9. diarrhea
  10. diplopia
  11. dizziness
  12. drowsiness
  13. euphoria
  14. excitability
  15. fatigue
  16. headache
  17. hemolytic anemia
  18. hyperhidrosis
  19. hypotension
  20. impaired cognition
  21. increased urinary frequency
  22. insomnia
  23. irritability
  24. nausea
  25. neuritis
  26. palpitations
  27. paresthesias
  28. photosensitivity
  29. restlessness
  30. seizures
  31. sinus tachycardia
  32. thrombocytopenia
  33. tinnitus
  34. tremor
  35. urinary retention
  36. urticaria
  37. vertigo
  38. vomiting
  39. weakness
  40. xerophthalmia
  41. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticholinergic medications
  • asthma
  • bladder obstruction
  • breast-feeding
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • driving or operating machinery
  • geriatric
  • GI obstruction
  • hepatic disease
  • ileus
  • infants
  • neonates
  • pregnancy
  • prostatic hypertrophy
  • urinary retention

Interactions

  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzphetamine
  • Bethanechol
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Clobazam
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Daratumumab; Hyaluronidase
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Deutetrabenazine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan; Promethazine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dronabinol
  • Droperidol
  • Entacapone
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Isocarboxazid
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lithium
  • Lofexidine
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Mephobarbital
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Methohexital
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Olanzapine
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Pentobarbital
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenobarbital
  • Phenylephrine; Promethazine
  • Pimozide
  • Pitolisant
  • Pramipexole
  • Pregabalin
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Secobarbital
  • Selegiline
  • Sincalide
  • Sodium Iodide
  • Solifenacin
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tapentadol
  • Tasimelteon
  • Thalidomide
  • Thiopental
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tramadol
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trospium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem

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