Clindamycin

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Clindamycin Brand Names

Cleocin | Cleocin Ovules | Cleocin Pediatric | Cleocin T | CLIN | Clindacin ETZ | Clindacin-P | Clinda-Derm | Clindagel | ClindaMax | ClindaReach | Clindesse | Clindets | Evoclin | PledgaClin

What is Clindamycin

Clindamycin is an antibiotic structurally similar to lincomycin, from which it is derived.

Clindamycin traditionally has been considered an effective anti-anaerobic antibiotic, but it recently has been shown to be effective in combination with pyrimethamine in treating toxoplasmic encephalitis in patients with AIDS.

Clindamycin was approved by the FDA in 1970 and is marketed as the hydrochloride salt for oral administration and as the phosphate salt for parenteral, topical or vaginal administration.

The FDA approved a single-dose vaginal cream (Clindesse™) for bacterial vaginosis in November 2004.

The FDA approved Evoclin™, an aerosol topical foam containing 1% clindamycin, for the treatment of acne vulgaris in December 2004.

Indications

  1. acne vulgaris
  2. Actinomyces israelii
  3. anthrax
  4. anthrax prophylaxis
  5. aspiration pneumonia
  6. babesiosis
  7. bacteremia
  8. bacterial colonization eradication
  9. bacterial vaginosis
  10. Bacteroides fragilis
  11. bone and joint infections
  12. cellulitis
  13. Clostridium clostridioforme
  14. Clostridium perfringens
  15. community-acquired pneumonia
  16. dental abscess (apical)
  17. dental abscess (periapical)
  18. dental infection
  19. dentoalveolar infection
  20. diabetic foot ulcer
  21. Eggerthella lenta
  22. endocarditis prophylaxis
  23. endodontic infection
  24. endometritis
  25. erysipelas
  26. Fusobacterium necrophorum
  27. Fusobacterium nucleatum
  28. gas gangrene
  29. gynecologic infections
  30. impetigo
  31. infectious arthritis
  32. infectious neonatal pustulosis
  33. intraabdominal abscess
  34. intraabdominal infections
  35. lower respiratory tract infections
  36. lung abscess
  37. malaria
  38. mastitis
  39. orthopedic device-related infection
  40. osteomyelitis
  41. otitis media
  42. pelvic inflammatory disease (PID)
  43. Peptostreptococcus anaerobius
  44. Peptostreptococcus magnus
  45. Peptostreptococcus micros
  46. perinatal Group B streptococcal infection prophylaxis
  47. periodontitis
  48. peritonitis
  49. pharyngitis
  50. Plasmodium falciparum
  51. pleural empyema
  52. Pneumocystis jirovecii (formerly Pneumocystis carinii)
  53. Pneumocystis pneumonia (PCP)
  54. Pneumocystis pneumonia (PCP) prophylaxis
  55. pneumonia
  56. Prevotella bivia
  57. Prevotella intermedia
  58. Prevotella melaninogenica
  59. Propionibacterium acnes
  60. Propionibacterium sp.
  61. rheumatic fever prophylaxis
  62. sinusitis
  63. skin and skin structure infections
  64. Staphylococcus aureus (MRSA)
  65. Staphylococcus aureus (MSSA)
  66. Staphylococcus epidermidis
  67. Streptococcus agalactiae (group B streptococci)
  68. Streptococcus anginosus
  69. Streptococcus mitis
  70. Streptococcus oralis
  71. Streptococcus pneumoniae
  72. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  73. surgical infection prophylaxis
  74. Toxoplasma gondii
  75. toxoplasmic encephalitis
  76. toxoplasmosis
  77. toxoplasmosis prophylaxis
  78. tubo-ovarian abscess

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. anaphylactic shock
  5. anaphylactoid reactions
  6. angioedema
  7. azotemia
  8. back pain
  9. bullous rash
  10. candidiasis
  11. cardiac arrest
  12. constipation
  13. contact dermatitis
  14. diarrhea
  15. dizziness
  16. Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
  17. dysgeusia
  18. dysmenorrhea
  19. dyspepsia
  20. dysphagia
  21. dysuria
  22. edema
  23. elevated hepatic enzymes
  24. eosinophilia
  25. epistaxis
  26. erythema
  27. erythema multiforme
  28. esophagitis
  29. exfoliative dermatitis
  30. fatigue
  31. fever
  32. flatulence
  33. folliculitis
  34. halitosis
  35. headache
  36. hyperthyroidism
  37. hypotension
  38. infection
  39. injection site reaction
  40. jaundice
  41. leukopenia
  42. maculopapular rash
  43. nausea
  44. neutropenia
  45. ocular irritation
  46. ocular pain
  47. odynophagia
  48. oliguria
  49. pelvic pain
  50. phlebitis
  51. proteinuria
  52. pruritus
  53. pseudomembranous colitis
  54. rash
  55. seborrhea
  56. Stevens-Johnson syndrome
  57. superinfection
  58. thrombocytopenia
  59. toxic epidermal necrolysis
  60. urticaria
  61. vaginal bleeding
  62. vaginal discharge
  63. vaginal irritation
  64. vaginal pain
  65. vaginitis
  66. vertigo
  67. vesicular rash
  68. vomiting
  69. xerosis

Monitoring Parameters

  • LFTs

Contraindications

  • asthma
  • atopy
  • breast-feeding
  • clindamycin hypersensitivity
  • diarrhea
  • fungal infection
  • geriatric
  • hepatic disease
  • inflammatory bowel disease
  • lincomycin hypersensitivity
  • neonates
  • ocular exposure
  • pregnancy
  • pseudomembranous colitis
  • serious rash
  • sexually transmitted disease
  • tartrazine dye hypersensitivity
  • ulcerative colitis

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Apalutamide
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
  • Atazanavir; Cobicistat
  • Atracurium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Azelastine; Fluticasone
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Betamethasone
  • Boceprevir
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Capreomycin
  • Carbamazepine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Ceritinib
  • Chloramphenicol
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Ciclesonide
  • Cisatracurium
  • Clarithromycin
  • Cobicistat
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Conivaptan
  • Corticosteroids
  • Cortisone
  • Cyclosporine
  • Darunavir
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Delavirdine
  • Dexamethasone
  • Dienogest; Estradiol valerate
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Doxacurium
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Enflurane
  • Enzalutamide
  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Fentanyl
  • Fludrocortisone
  • Flunisolide
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol; Mometasone
  • Fosamprenavir
  • Fosphenytoin
  • grapefruit juice
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halothane
  • Homatropine; Hydrocodone
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Idelalisib
  • Indinavir
  • Isoflurane
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Itraconazole
  • Ketoconazole
  • Letermovir
  • Levorphanol
  • Lithium
  • Lopinavir; Ritonavir
  • Lumacaftor; Ivacaftor
  • Lumacaftor; Ivacaftor
  • Meperidine
  • Meperidine; Promethazine
  • Methadone
  • Methylprednisolone
  • Mifepristone
  • Mitotane
  • Mivacurium
  • Mometasone
  • Morphine
  • Morphine; Naltrexone
  • Nefazodone
  • Nelfinavir
  • Neuromuscular blockers
  • Ombitasvir; Paritaprevir; Ritonavir
  • Opiate Agonists
  • Oral Contraceptives
  • Oxycodone
  • Oxymorphone
  • Pancuronium
  • Phenobarbital
  • Phenytoin
  • Polymyxins
  • Posaconazole
  • Prednisolone
  • Prednisone
  • Primidone
  • Propoxyphene
  • Rapacuronium
  • Remifentanil
  • Rifampin
  • Ritonavir
  • Rocuronium
  • Salicylic Acid
  • Sevoflurane
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sodium Thiosulfate; Salicylic Acid
  • St. John’s Wort, Hypericum perforatum
  • Succinylcholine
  • Sufentanil
  • Telithromycin
  • Tolvaptan
  • Triamcinolone
  • Tubocurarine
  • Tucatinib
  • Vecuronium
  • Voriconazole

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