Ceftolozane Tazobactam

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Ceftolozane Tazobactam Brand Name– ZERBAXA

What is Ceftolozane Tazobactam

Ceftolozane tazobactam is a combination intravenous anti-infective, including ceftolozane, a cephalosporin antibacterial, and tazobactam, a beta-lactamase inhibitor, indicated for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) in adults.

Decreased efficacy has been observed with ceftolozane; tazobactam use in patients with renal impairment.

In a subgroup analysis of a phase 3 complicated intraabdominal infection trial, clinical cure rates were lower in patients with a baseline creatinine clearance (CrCl) of 30 to 50 mL/minute compared to those with a CrCl more than 50 mL/minute.

A similar trend was noted in the complicated urinary tract infection trial.

Indications

  1. appendicitis
  2. Bacteroides fragilis
  3. cholecystitis
  4. Citrobacter koseri
  5. diverticulitis
  6. Enterobacter cloacae
  7. Escherichia coli
  8. Haemophilus influenzae (beta-lactamase negative)
  9. Haemophilus influenzae (beta-lactamase positive)
  10. intraabdominal abscess
  11. intraabdominal infections
  12. Klebsiella aerogenes
  13. Klebsiella oxytoca
  14. Klebsiella pneumoniae
  15. Morganella morganii
  16. nosocomial pneumonia
  17. peritonitis
  18. pneumonia
  19. Proteus mirabilis
  20. Proteus vulgaris
  21. Providencia rettgeri
  22. Providencia stuartii
  23. Pseudomonas aeruginosa
  24. pyelonephritis
  25. sepsis
  26. Serratia liquefaciens
  27. Serratia marcescens
  28. Streptococcus agalactiae (group B streptococci)
  29. Streptococcus anginosus
  30. Streptococcus constellatus
  31. Streptococcus intermedius
  32. Streptococcus salivarius
  33. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. anemia
  3. angina
  4. anuria
  5. anxiety
  6. atrial fibrillation
  7. azotemia
  8. candidiasis
  9. constipation
  10. diarrhea
  11. dizziness
  12. dyspepsia
  13. dyspnea
  14. elevated hepatic enzymes
  15. fever
  16. flatulence
  17. gastritis
  18. headache
  19. hyperglycemia
  20. hypokalemia
  21. hypomagnesemia
  22. hypophosphatemia
  23. hypotension
  24. ileus
  25. infection
  26. injection site reaction
  27. insomnia
  28. intracranial bleeding
  29. intraventricular hemorrhage
  30. nausea
  31. oliguria
  32. pseudomembranous colitis
  33. rash
  34. renal failure (unspecified)
  35. sinus tachycardia
  36. stroke
  37. subdural hematoma
  38. thrombocytosis
  39. thrombosis
  40. urticaria
  41. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • hypoprothrombinemia
  • inflammatory bowel disease
  • laboratory test interference
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Colchicine; Probenecid
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Probenecid
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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