Ceftolozane Tazobactam Brand Name– ZERBAXA
What is Ceftolozane Tazobactam
Ceftolozane tazobactam is a combination intravenous anti-infective, including ceftolozane, a cephalosporin antibacterial, and tazobactam, a beta-lactamase inhibitor, indicated for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, hospital-acquired pneumonia (HAP), and ventilator-associated pneumonia (VAP) in adults.
Decreased efficacy has been observed with ceftolozane; tazobactam use in patients with renal impairment.
In a subgroup analysis of a phase 3 complicated intraabdominal infection trial, clinical cure rates were lower in patients with a baseline creatinine clearance (CrCl) of 30 to 50 mL/minute compared to those with a CrCl more than 50 mL/minute.
A similar trend was noted in the complicated urinary tract infection trial.
Indications
- appendicitis
- Bacteroides fragilis
- cholecystitis
- Citrobacter koseri
- diverticulitis
- Enterobacter cloacae
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal abscess
- intraabdominal infections
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Morganella morganii
- nosocomial pneumonia
- peritonitis
- pneumonia
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- pyelonephritis
- sepsis
- Serratia liquefaciens
- Serratia marcescens
- Streptococcus agalactiae (group B streptococci)
- Streptococcus anginosus
- Streptococcus constellatus
- Streptococcus intermedius
- Streptococcus salivarius
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- anemia
- angina
- anuria
- anxiety
- atrial fibrillation
- azotemia
- candidiasis
- constipation
- diarrhea
- dizziness
- dyspepsia
- dyspnea
- elevated hepatic enzymes
- fever
- flatulence
- gastritis
- headache
- hyperglycemia
- hypokalemia
- hypomagnesemia
- hypophosphatemia
- hypotension
- ileus
- infection
- injection site reaction
- insomnia
- intracranial bleeding
- intraventricular hemorrhage
- nausea
- oliguria
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- sinus tachycardia
- stroke
- subdural hematoma
- thrombocytosis
- thrombosis
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- dialysis
- diarrhea
- geriatric
- GI disease
- hypoprothrombinemia
- inflammatory bowel disease
- laboratory test interference
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- ulcerative colitis
- vitamin K deficiency
Interactions
- Colchicine; Probenecid
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Probenecid
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin