Cefadroxil

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Cefadroxil Brand Name– Duricef

What is Cefadroxil

Cefadroxil is an oral first-generation cephalosporin antibiotic.

Its spectrum includes gram-positive organisms, but it has limited gram-negative coverage.

Cefadroxil is indicated for the treatment of urinary tract infections, skin and skin structure infections, pharyngitis, and tonsillitis.

This drug was approved by the FDA in 1978.

Indications

  1. cystitis
  2. Escherichia coli
  3. impetigo
  4. Klebsiella sp.
  5. Moraxella catarrhalis
  6. pharyngitis
  7. Proteus mirabilis
  8. rheumatic fever prophylaxis
  9. skin and skin structure infections
  10. Staphylococcus sp.
  11. Streptococcus pneumoniae
  12. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  13. tonsillitis
  14. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. angioedema
  5. aplastic anemia
  6. arthralgia
  7. azotemia
  8. bleeding
  9. candidiasis
  10. cholestasis
  11. diarrhea
  12. dyspepsia
  13. elevated hepatic enzymes
  14. eosinophilia
  15. erythema multiforme
  16. fever
  17. hemolytic anemia
  18. hepatic failure
  19. hyperbilirubinemia
  20. interstitial nephritis
  21. nausea
  22. neutropenia
  23. pancytopenia
  24. pruritus
  25. pseudomembranous colitis
  26. rash
  27. seizures
  28. serum sickness
  29. Stevens-Johnson syndrome
  30. superinfection
  31. thrombocytopenia
  32. toxic epidermal necrolysis
  33. urticaria
  34. vaginitis
  35. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • inflammatory bowel disease
  • intramuscular injections
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal impairment
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Clofarabine
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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