Ceftizoxime Brand Name
What is Ceftizoxime
Ceftizoxime is a parenteral third-generation cephalosporin antibiotic. Its spectrum includes some gram-positive organisms but has predominantly gram-negative coverage.
Ceftizoxime is indicated for the treatment of upper and lower respiratory tract infections, sexually transmitted diseases, intra-abdominal infections, septicemia, bone and joint infections, meningitis caused by Haemophilus influenzae, urinary tract infections, and skin and skin structure infections.
This drug was approved by the FDA in 1983.
Indications
- Actinomyces sp.
- Aeromonas hydrophila
- bacteremia
- Bacteroides fragilis
- Bacteroides sp.
- Bifidobacterium sp.
- bone and joint infections
- cervicitis
- Citrobacter sp.
- Corynebacterium diphtheriae
- Enterobacter sp.
- Escherichia coli
- Eubacterium sp.
- Fusobacterium sp.
- gonorrhea
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal infections
- Klebsiella pneumoniae
- Klebsiella sp.
- lower respiratory tract infections
- meningitis
- Moraxella catarrhalis
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- osteomyelitis
- Pasteurella multocida
- pelvic inflammatory disease (PID)
- Peptococcus sp.
- Peptostreptococcus sp.
- Propionibacterium sp.
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia sp.
- Providencia stuartii
- Pseudomonas aeruginosa
- Pseudomonas sp.
- Salmonella sp.
- Serratia marcescens
- Serratia sp.
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp.
- urethritis
- urinary tract infection (UTI)
- Veillonella sp.
- Yersinia enterocolitica
Side Effects
- agranulocytosis
- anaphylactoid reactions
- anemia
- angioedema
- aplastic anemia
- azotemia
- bleeding
- colitis
- diarrhea
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- hemolytic anemia
- hypoprothrombinemia
- injection site reaction
- leukopenia
- nausea
- neutropenia
- pancytopenia
- paresthesias
- phlebitis
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- thrombocytosis
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- dialysis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- labor
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal disease
- renal impairment
- sexually transmitted disease
- ulcerative colitis
- viral infection
- vitamin K deficiency
Interactions
- Amikacin
- Aminoglycosides
- Dichlorphenamide
- Gentamicin
- Kanamycin
- Loop diuretics
- Oral Contraceptives
- Paromomycin
- Plazomicin
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Streptomycin
- Tobramycin
- Warfarin
