Ceftizoxime

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Ceftizoxime Brand Name

What is Ceftizoxime

Ceftizoxime is a parenteral third-generation cephalosporin antibiotic. Its spectrum includes some gram-positive organisms but has predominantly gram-negative coverage.

Ceftizoxime is indicated for the treatment of upper and lower respiratory tract infections, sexually transmitted diseases, intra-abdominal infections, septicemia, bone and joint infections, meningitis caused by Haemophilus influenzae, urinary tract infections, and skin and skin structure infections.

This drug was approved by the FDA in 1983.

Indications

  1. Actinomyces sp.
  2. Aeromonas hydrophila
  3. bacteremia
  4. Bacteroides fragilis
  5. Bacteroides sp.
  6. Bifidobacterium sp.
  7. bone and joint infections
  8. cervicitis
  9. Citrobacter sp.
  10. Corynebacterium diphtheriae
  11. Enterobacter sp.
  12. Escherichia coli
  13. Eubacterium sp.
  14. Fusobacterium sp.
  15. gonorrhea
  16. Haemophilus influenzae (beta-lactamase negative)
  17. Haemophilus influenzae (beta-lactamase positive)
  18. intraabdominal infections
  19. Klebsiella pneumoniae
  20. Klebsiella sp.
  21. lower respiratory tract infections
  22. meningitis
  23. Moraxella catarrhalis
  24. Morganella morganii
  25. Neisseria gonorrhoeae
  26. Neisseria meningitidis
  27. osteomyelitis
  28. Pasteurella multocida
  29. pelvic inflammatory disease (PID)
  30. Peptococcus sp.
  31. Peptostreptococcus sp.
  32. Propionibacterium sp.
  33. Proteus mirabilis
  34. Proteus vulgaris
  35. Providencia rettgeri
  36. Providencia sp.
  37. Providencia stuartii
  38. Pseudomonas aeruginosa
  39. Pseudomonas sp.
  40. Salmonella sp.
  41. Serratia marcescens
  42. Serratia sp.
  43. Shigella sp.
  44. skin and skin structure infections
  45. Staphylococcus aureus (MSSA)
  46. Staphylococcus epidermidis
  47. Streptococcus agalactiae (group B streptococci)
  48. Streptococcus pneumoniae
  49. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  50. Streptococcus sp.
  51. urethritis
  52. urinary tract infection (UTI)
  53. Veillonella sp.
  54. Yersinia enterocolitica

Side Effects

  1. agranulocytosis
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. aplastic anemia
  6. azotemia
  7. bleeding
  8. colitis
  9. diarrhea
  10. elevated hepatic enzymes
  11. eosinophilia
  12. erythema multiforme
  13. fever
  14. hemolytic anemia
  15. hypoprothrombinemia
  16. injection site reaction
  17. leukopenia
  18. nausea
  19. neutropenia
  20. pancytopenia
  21. paresthesias
  22. phlebitis
  23. prolonged bleeding time
  24. pruritus
  25. pseudomembranous colitis
  26. rash
  27. seizures
  28. serum sickness
  29. Stevens-Johnson syndrome
  30. superinfection
  31. thrombocytopenia
  32. thrombocytosis
  33. toxic epidermal necrolysis
  34. urticaria
  35. vaginitis
  36. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • labor
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal impairment
  • sexually transmitted disease
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Amikacin
  • Aminoglycosides
  • Dichlorphenamide
  • Gentamicin
  • Kanamycin
  • Loop diuretics
  • Oral Contraceptives
  • Paromomycin
  • Plazomicin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptomycin
  • Tobramycin
  • Warfarin

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