Ceftriaxone

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Ceftriaxone Brand Name– Ceftrisol Plus | Rocephin

What is Ceftriaxone

Ceftriaxone is a parenteral third-generation cephalosporin. Similar to other third-generation cephalosporins, ceftriaxone possesses significant activity against serious gram-negative organisms and also penetrates the CSF in concentrations that make it useful in the treatment of meningitis.

Ceftriaxone has the longest half-life of all cephalosporins, allowing for once-daily dosing and making it a useful antibiotic for outpatient therapy.

Ceftriaxone was approved by the FDA in December 1984.

Indications

  1. Acinetobacter calcoaceticus
  2. Actinomyces sp.
  3. appendicitis
  4. bacteremia
  5. bacterial colonization eradication
  6. bacterial conjunctivitis
  7. bacterial infection prophylaxis
  8. Bacteroides bivius
  9. Bacteroides fragilis
  10. biliary tract infections
  11. bone and joint infections
  12. Borrelia burgdorferi
  13. brain abscess
  14. chancroid
  15. cholecystitis
  16. Citrobacter diversus
  17. Citrobacter freundii
  18. Clostridium sp.
  19. community-acquired pneumonia
  20. diabetic foot ulcer
  21. Eikenella corrodens
  22. endocarditis
  23. endocarditis prophylaxis
  24. Enterobacter cloacae
  25. epididymitis
  26. Escherichia coli
  27. Fusobacterium sp.
  28. gastroenteritis
  29. gonorrhea
  30. gonorrhea prophylaxis
  31. Haemophilus ducreyi
  32. Haemophilus influenzae (beta-lactamase negative)
  33. Haemophilus influenzae (beta-lactamase positive)
  34. Haemophilus parainfluenzae
  35. infectious diarrhea
  36. intraabdominal infections
  37. Klebsiella aerogenes
  38. Klebsiella oxytoca
  39. Klebsiella pneumoniae
  40. Lactobacillus sp.
  41. Leptospira sp.
  42. leptospirosis
  43. lower respiratory tract infections
  44. Lyme disease
  45. meningitis
  46. meningococcal infection prophylaxis
  47. Moraxella catarrhalis
  48. Morganella morganii
  49. Neisseria gonorrhoeae
  50. Neisseria meningitidis
  51. neurosyphilis
  52. ophthalmia neonatorum
  53. ophthalmia neonatorum prophylaxis
  54. osteomyelitis
  55. otitis media
  56. pelvic inflammatory disease (PID)
  57. Peptococcus sp.
  58. Peptostreptococcus sp.
  59. pleural empyema
  60. pneumonia
  61. Prevotella melaninogenica
  62. Propionibacterium sp.
  63. Proteus mirabilis
  64. Proteus vulgaris
  65. Providencia rettgeri
  66. Providencia sp.
  67. Salmonella sp.
  68. Salmonella typhi
  69. salmonellosis
  70. sepsis
  71. Serratia marcescens
  72. Shigella sp.
  73. sinusitis
  74. skin and skin structure infections
  75. Staphylococcus aureus (MSSA)
  76. Staphylococcus epidermidis
  77. Streptococcus agalactiae (group B streptococci)
  78. Streptococcus pneumoniae
  79. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  80. surgical infection prophylaxis
  81. syphilis
  82. typhoid fever
  83. urinary tract infection (UTI)
  84. Veillonella sp.
  85. Viridans streptococci
  86. Yersinia enterocolitica

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. aplastic anemia
  8. azotemia
  9. biliary obstruction
  10. bleeding
  11. bronchospasm
  12. candidiasis
  13. chills
  14. cholelithiasis
  15. cholestasis
  16. colitis
  17. diaphoresis
  18. diarrhea
  19. dizziness
  20. dysgeusia
  21. dyspepsia
  22. edema
  23. elevated hepatic enzymes
  24. eosinophilia
  25. epistaxis
  26. erythema multiforme
  27. fever
  28. flatulence
  29. flushing
  30. glossitis
  31. glycosuria
  32. headache
  33. hematuria
  34. hemolytic anemia
  35. hyperbilirubinemia
  36. hypertonia
  37. hypoprothrombinemia
  38. injection site reaction
  39. Jarisch-Herxheimer reaction
  40. jaundice
  41. leukocytosis
  42. leukopenia
  43. lymphocytosis
  44. lymphopenia
  45. nausea
  46. nephrolithiasis
  47. neutropenia
  48. oliguria
  49. palpitations
  50. pancreatitis
  51. phlebitis
  52. pneumonitis
  53. pruritus
  54. pseudomembranous colitis
  55. rash
  56. renal failure (unspecified)
  57. seizures
  58. serum sickness
  59. Stevens-Johnson syndrome
  60. stomatitis
  61. superinfection
  62. thrombocytopenia
  63. thrombocytosis
  64. toxic epidermal necrolysis
  65. urticaria
  66. vaginitis
  67. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary
  • LFTs

Contraindications

  • antimicrobial resistance
  • breast-feeding
  • cephalosporin hypersensitivity
  • coadministration of calcium-containing IV’s
  • coagulopathy
  • colitis
  • diarrhea
  • gallbladder disease
  • geriatric
  • GI disease
  • hepatic disease
  • inflammatory bowel disease
  • intramuscular injections
  • jaundice
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • premature neonates
  • pseudomembranous colitis
  • renal failure
  • sexually transmitted disease
  • ulcerative colitis
  • urinary tract obstruction
  • viral infection
  • vitamin K deficiency

Interactions

  • Calcium Acetate
  • Calcium Chloride
  • Calcium Gluconate
  • Cyclosporine
  • Loop diuretics
  • Oral Contraceptives
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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