Cefaclor

Sharing is caring!

Cefaclor Brand Names

Ceclor | Ceclor CD | Raniclor

What is Cefaclor

Cefaclor is an oral, second-generation cephalosporin.

The spectrum of activity of cefaclor more closely resembles first-generation than second-generation cephalosporins, causing some clinicians to consider it a first-generation agent.

Cefaclor has slightly improved activity against Haemophilus influenzae compared with cephalexin, a first-generation cephalosporin.

Clinically, cefaclor is used primarily to treat otitis media, sinusitis, and upper respiratory tract infection caused by H. influenzae that are resistant to ampicillin or amoxicillin. Cefaclor was approved by the FDA in 1979.

Indications

  1. Bacteroides sp.
  2. bronchitis
  3. Citrobacter diversus
  4. cystitis
  5. Escherichia coli
  6. Haemophilus influenzae (beta-lactamase negative)
  7. Haemophilus parainfluenzae
  8. Klebsiella pneumoniae
  9. Klebsiella sp.
  10. lower respiratory tract infections
  11. Moraxella catarrhalis
  12. Neisseria gonorrhoeae
  13. otitis media
  14. Peptococcus niger
  15. Peptococcus sp.
  16. Peptostreptococcus sp.
  17. pharyngitis
  18. pneumonia
  19. Propionibacterium acnes
  20. Proteus mirabilis
  21. pyelonephritis
  22. Shigella sp.
  23. skin and skin structure infections
  24. Staphylococcus aureus (MSSA)
  25. Staphylococcus epidermidis
  26. Staphylococcus sp.
  27. Streptococcus agalactiae (group B streptococci)
  28. Streptococcus pneumoniae
  29. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  30. tonsillitis
  31. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agitation
  4. agranulocytosis
  5. anaphylactoid reactions
  6. angioedema
  7. anorexia
  8. anxiety
  9. aplastic anemia
  10. arthralgia
  11. back pain
  12. bleeding
  13. candidiasis
  14. chest pain (unspecified)
  15. chills
  16. cholestasis
  17. confusion
  18. conjunctivitis
  19. constipation
  20. cough
  21. diarrhea
  22. dizziness
  23. drowsiness
  24. dysmenorrhea
  25. dyspepsia
  26. dysuria
  27. edema
  28. elevated hepatic enzymes
  29. eosinophilia
  30. erythema multiforme
  31. fever
  32. flatulence
  33. gastritis
  34. hallucinations
  35. headache
  36. heart failure
  37. hemolytic anemia
  38. hepatitis
  39. hyperbilirubinemia
  40. hyperhidrosis
  41. hypertonia
  42. hypoprothrombinemia
  43. influenza
  44. insomnia
  45. interstitial nephritis
  46. jaundice
  47. leukopenia
  48. leukorrhea
  49. lymphocytosis
  50. maculopapular rash
  51. malaise
  52. myalgia
  53. nausea
  54. neutropenia
  55. nocturia
  56. palpitations
  57. pancytopenia
  58. peripheral edema
  59. pharyngitis
  60. pruritus
  61. pseudomembranous colitis
  62. rash
  63. rhinitis
  64. seizures
  65. serum sickness
  66. sinusitis
  67. Stevens-Johnson syndrome
  68. superinfection
  69. thrombocytopenia
  70. toxic epidermal necrolysis
  71. tremor
  72. urticaria
  73. vaginitis
  74. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • antimicrobial resistance
  • breast-feeding
  • cephalosporin hypersensitivity
  • children
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Colchicine; Probenecid
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Leflunomide
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Probenecid
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Teriflunomide
  • Warfarin

Sharing is caring!

You cannot copy content of this page

15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top