Cefaclor Brand Names
Ceclor | Ceclor CD | Raniclor
What is Cefaclor
Cefaclor is an oral, second-generation cephalosporin.
The spectrum of activity of cefaclor more closely resembles first-generation than second-generation cephalosporins, causing some clinicians to consider it a first-generation agent.
Cefaclor has slightly improved activity against Haemophilus influenzae compared with cephalexin, a first-generation cephalosporin.
Clinically, cefaclor is used primarily to treat otitis media, sinusitis, and upper respiratory tract infection caused by H. influenzae that are resistant to ampicillin or amoxicillin. Cefaclor was approved by the FDA in 1979.
Indications
- Bacteroides sp.
- bronchitis
- Citrobacter diversus
- cystitis
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus parainfluenzae
- Klebsiella pneumoniae
- Klebsiella sp.
- lower respiratory tract infections
- Moraxella catarrhalis
- Neisseria gonorrhoeae
- otitis media
- Peptococcus niger
- Peptococcus sp.
- Peptostreptococcus sp.
- pharyngitis
- pneumonia
- Propionibacterium acnes
- Proteus mirabilis
- pyelonephritis
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus sp.
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- tonsillitis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- acute generalized exanthematous pustulosis (AGEP)
- agitation
- agranulocytosis
- anaphylactoid reactions
- angioedema
- anorexia
- anxiety
- aplastic anemia
- arthralgia
- back pain
- bleeding
- candidiasis
- chest pain (unspecified)
- chills
- cholestasis
- confusion
- conjunctivitis
- constipation
- cough
- diarrhea
- dizziness
- drowsiness
- dysmenorrhea
- dyspepsia
- dysuria
- edema
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- flatulence
- gastritis
- hallucinations
- headache
- heart failure
- hemolytic anemia
- hepatitis
- hyperbilirubinemia
- hyperhidrosis
- hypertonia
- hypoprothrombinemia
- influenza
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- leukorrhea
- lymphocytosis
- maculopapular rash
- malaise
- myalgia
- nausea
- neutropenia
- nocturia
- palpitations
- pancytopenia
- peripheral edema
- pharyngitis
- pruritus
- pseudomembranous colitis
- rash
- rhinitis
- seizures
- serum sickness
- sinusitis
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- toxic epidermal necrolysis
- tremor
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- antimicrobial resistance
- breast-feeding
- cephalosporin hypersensitivity
- children
- coagulopathy
- colitis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- neonates
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- ulcerative colitis
- viral infection
- vitamin K deficiency
Interactions
- Colchicine; Probenecid
- Dichlorphenamide
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Leflunomide
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Probenecid
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Teriflunomide
- Warfarin
