Cefoperazone Brand Name– Cefobid
What is Cefoperazone
Cefoperazone is a parenteral third-generation cephalosporin. It differs structurally from other cephalosporins by the addition of a piperazine side chain and a methyltetrazolethiol side chain.
The piperazine side chain imparts improved antipseudomonal activity, whereas the methyltetrazolethiol side chain is believed to be responsible for the hypoprothrombinemia associated with cefoperazone.
The most common therapeutic use of cefoperazone is as a second-line agent in the treatment of lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, gynecologic infections, and intra-abdominal infections due to susceptible organisms.
Cefoperazone was approved by the FDA in November 1982.
Indications
- bacteremia
- Bacteroides fragilis
- Bacteroides sp.
- Bordetella pertussis
- Citrobacter sp.
- Clostridium sp.
- endometritis
- Enterobacter sp.
- Escherichia coli
- Eubacterium sp.
- Fusobacterium sp.
- gynecologic infections
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- intraabdominal infections
- Klebsiella pneumoniae
- Klebsiella sp.
- lower respiratory tract infections
- Morganella morganii
- Neisseria gonorrhoeae
- Neisseria meningitidis
- pelvic inflammatory disease (PID)
- Peptococcus sp.
- Peptostreptococcus sp.
- peritonitis
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- Providencia stuartii
- Pseudomonas aeruginosa
- Pseudomonas sp.
- Salmonella sp.
- Serratia liquefaciens
- Serratia marcescens
- Shigella sp.
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- upper respiratory tract infections
- urinary tract infection (UTI)
- Yersinia enterocolitica
Monitoring Parameters
- LFTs
- prothrombin time (PT)
Contraindications
- alcoholism
- bleeding
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- diarrhea
- ethanol intoxication
- geriatric
- GI disease
- hepatic disease
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- sexually transmitted disease
- ulcerative colitis
- vitamin K deficiency
Interactions
- Ethanol
- Loop diuretics
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
