Cefoperazone

Cefoperazone Brand Name– Cefobid

What is Cefoperazone

Cefoperazone is a parenteral third-generation cephalosporin. It differs structurally from other cephalosporins by the addition of a piperazine side chain and a methyltetrazolethiol side chain.

The piperazine side chain imparts improved antipseudomonal activity, whereas the methyltetrazolethiol side chain is believed to be responsible for the hypoprothrombinemia associated with cefoperazone.

The most common therapeutic use of cefoperazone is as a second-line agent in the treatment of lower respiratory tract infections, skin and soft-tissue infections, urinary tract infections, gynecologic infections, and intra-abdominal infections due to susceptible organisms.

Cefoperazone was approved by the FDA in November 1982.

Indications

  1. bacteremia
  2. Bacteroides fragilis
  3. Bacteroides sp.
  4. Bordetella pertussis
  5. Citrobacter sp.
  6. Clostridium sp.
  7. endometritis
  8. Enterobacter sp.
  9. Escherichia coli
  10. Eubacterium sp.
  11. Fusobacterium sp.
  12. gynecologic infections
  13. Haemophilus influenzae (beta-lactamase negative)
  14. Haemophilus influenzae (beta-lactamase positive)
  15. intraabdominal infections
  16. Klebsiella pneumoniae
  17. Klebsiella sp.
  18. lower respiratory tract infections
  19. Morganella morganii
  20. Neisseria gonorrhoeae
  21. Neisseria meningitidis
  22. pelvic inflammatory disease (PID)
  23. Peptococcus sp.
  24. Peptostreptococcus sp.
  25. peritonitis
  26. Proteus mirabilis
  27. Proteus vulgaris
  28. Providencia rettgeri
  29. Providencia stuartii
  30. Pseudomonas aeruginosa
  31. Pseudomonas sp.
  32. Salmonella sp.
  33. Serratia liquefaciens
  34. Serratia marcescens
  35. Shigella sp.
  36. skin and skin structure infections
  37. Staphylococcus aureus (MSSA)
  38. Staphylococcus epidermidis
  39. Streptococcus agalactiae (group B streptococci)
  40. Streptococcus pneumoniae
  41. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  42. upper respiratory tract infections
  43. urinary tract infection (UTI)
  44. Yersinia enterocolitica

Monitoring Parameters

  • LFTs
  • prothrombin time (PT)

Contraindications

  • alcoholism
  • bleeding
  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • ethanol intoxication
  • geriatric
  • GI disease
  • hepatic disease
  • inflammatory bowel disease
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • sexually transmitted disease
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Ethanol
  • Loop diuretics
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin
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