Ceftibuten

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Ceftibuten Brand Name– Cedax

What is Ceftibuten

Ceftibuten is an oral, third-generation cephalosporin.

Ceftibuten is more beta-lactamase stable compared to other beta-lactamase stable cephalosporins; however, ceftibuten is inactivated by type I beta-lactamase produced by EnterobacterPseudomonas, and Serratia species.

In addition, resistance occurs in over 15% of strains of Citrobacter freundii and Morganella morganii.

Although ceftibuten possesses activity against a variety of gram-negative and gram-positive bacteria, gram-positive activity with ceftibuten is less than for first generation agents.

Ceftibuten, like cefixime, has minimal activity against staphylococci, group B streptococci (Streptococcus agalactiae), and the enterococci.

About 95% of penicillin-susceptible Streptococcus pneumoniae have ceftibuten MICs less than 8 mcg/mL; however, ceftibuten and other orally administered beta-lactam antibiotics are not active against penicillin-resistant S. pneumoniae. In one study of patients with acute otitis media, ceftibuten was less effective than cefaclor in patients with infection due to S. pneumoniae (80% vs. 95%).

Therefore, the manufacturer recommends that ceftibuten should only be given empirically for acute otitis media when adequate antimicrobial coverage against S. pneumoniae has been previously administered.

Since ceftibuten is acid-stable, it does not require administration as a prodrug as do cefuroxime or cefpodoxime.

Ceftibuten was approved by the FDA December 20, 1995 for treatment of respiratory infections.

Limited data support the use of ceftibuten for the treatment of dysentery, pneumonia, or sinusitis.

Indications

  1. bronchitis
  2. Escherichia coli
  3. Haemophilus influenzae (beta-lactamase negative)
  4. Haemophilus influenzae (beta-lactamase positive)
  5. Moraxella catarrhalis
  6. otitis media
  7. pharyngitis
  8. pneumonia
  9. Shigella sp.
  10. shigellosis
  11. Streptococcus pneumoniae
  12. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  13. tonsillitis

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diabetes mellitus
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aspirin, ASA; Omeprazole
  • Cimetidine
  • Dexlansoprazole
  • Didanosine, ddI
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Famotidine
  • Famotidine; Ibuprofen
  • food
  • H2-blockers
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Nizatidine
  • Norethindrone
  • Norgestrel
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Pantoprazole
  • Proton pump inhibitors
  • Rabeprazole
  • Ranitidine
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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