Ceftazidime

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Ceftazidime Brand Names

Ceptaz | Fortaz | Tazicef | Tazidime

What is Ceftazidime

Ceftazidime is a parenteral third-generation cephalosporin. As a rule, third-generation cephalosporins are more active and have a broader spectrum against aerobic gram-negative bacteria than do either first- or second-generation agents.

Ceftazidime, like other third-generation cephalosporins, is less active against gram-positive organisms than are first-generation drugs.

Ceftazidime is extremely active against Pseudomonas aeruginosa, and is used frequently for pulmonary infections, particularly in patients with cystic fibrosis. Other therapeutic uses of ceftazidime include meningitis, skin and soft-tissue infections, urinary tract infections, and bone and joint infections.

Ceftazidime has been commonly used in the empiric treatment of fever in neutropenic patients.

However, higher rates of resistance among viridans-group streptococci have been noted with ceftazidime compared with cefepime; therefore, ceftazidime monotherapy should not be used if there are concerns about gram-positive or resistant gram-negative infections.

Ceftazidime was FDA-approved in July 1985.

Indications

  1. Acinetobacter sp.
  2. bacteremia
  3. Bacteroides sp.
  4. bone and joint infections
  5. Burkholderia pseudomallei
  6. Citrobacter diversus
  7. Citrobacter freundii
  8. Citrobacter sp.
  9. Clostridium sp.
  10. community-acquired pneumonia
  11. cystic fibrosis
  12. diabetic foot ulcer
  13. Eikenella corrodens
  14. endocarditis
  15. endometritis
  16. Enterobacter sp.
  17. Escherichia coli
  18. Eubacterium sp.
  19. febrile neutropenia
  20. gynecologic infections
  21. Haemophilus ducreyi
  22. Haemophilus influenzae (beta-lactamase negative)
  23. Haemophilus influenzae (beta-lactamase positive)
  24. Haemophilus parainfluenzae
  25. intraabdominal infections
  26. Klebsiella oxytoca
  27. Klebsiella pneumoniae
  28. Klebsiella sp.
  29. Lactobacillus sp.
  30. lower respiratory tract infections
  31. melioidosis
  32. meningitis
  33. Moraxella catarrhalis
  34. Morganella morganii
  35. Neisseria gonorrhoeae
  36. Neisseria meningitidis
  37. nosocomial pneumonia
  38. osteomyelitis
  39. Pantoea agglomerans
  40. Pasteurella multocida
  41. pelvic cellulitis
  42. Peptostreptococcus sp.
  43. peritonitis
  44. pneumonia
  45. Propionibacterium sp.
  46. Proteus mirabilis
  47. Proteus vulgaris
  48. Providencia rettgeri
  49. Providencia sp.
  50. Providencia stuartii
  51. Pseudomonas aeruginosa
  52. Pseudomonas sp.
  53. Salmonella sp.
  54. sepsis
  55. Serratia marcescens
  56. Serratia sp.
  57. Shigella sp.
  58. skin and skin structure infections
  59. Staphylococcus aureus (MSSA)
  60. Staphylococcus epidermidis
  61. Streptococcus agalactiae (group B streptococci)
  62. Streptococcus pneumoniae
  63. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  64. urinary tract infection (UTI)
  65. Viridans streptococci
  66. Yersinia enterocolitica

Side Effects

  1. abdominal pain
  2. acute generalized exanthematous pustulosis (AGEP)
  3. agranulocytosis
  4. angioedema
  5. aplastic anemia
  6. asterixis
  7. bronchospasm
  8. candidiasis
  9. cholestasis
  10. coma
  11. diarrhea
  12. dizziness
  13. elevated hepatic enzymes
  14. encephalopathy
  15. eosinophilia
  16. erythema multiforme
  17. fever
  18. headache
  19. hemolytic anemia
  20. hyperbilirubinemia
  21. hypoprothrombinemia
  22. hypotension
  23. injection site reaction
  24. interstitial nephritis
  25. jaundice
  26. leukopenia
  27. lymphocytosis
  28. maculopapular rash
  29. myoclonia
  30. nausea
  31. neutropenia
  32. pancytopenia
  33. paresthesias
  34. phlebitis
  35. pruritus
  36. pseudomembranous colitis
  37. seizures
  38. Stevens-Johnson syndrome
  39. superinfection
  40. thrombocytopenia
  41. thrombocytosis
  42. toxic epidermal necrolysis
  43. urticaria
  44. vaginitis
  45. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • inflammatory bowel disease
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Amikacin
  • Aminoglycosides
  • Gentamicin
  • Kanamycin
  • Loop diuretics
  • Oral Contraceptives
  • Paromomycin
  • Plazomicin
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptomycin
  • Tobramycin
  • Warfarin

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