Aztreonam

Aztreonam Brand Names- Azactam | Cayston

What is Aztreonam

Aztreonam is a parenteral synthetic beta-lactam antibiotic and the first monobactam to be marketed.

The spectrum of aztreonam is limited to aerobic gram-negative bacteria; it has no gram-positive or anaerobic activity.

Aztreonam may be used place of an aminoglycoside since it is less nephrotoxic. Clinical uses of aztreonam include bacteremias, skin and soft-tissue infections, urinary tract infections, respiratory tract infections, intra-abdominal infections, and gynecologic infections caused by susceptible organisms.

Aztreonam may also be used for postoperative infections including abscesses infections complicating viscous perforations, cutaneous infections, and infections of serous surfaces.

It is effective against most commonly seen gram-negative aerobic pathogens seen in general surgery.

Aztreonam is not indicated for meningitis.

Aztreonam inhalation therapy was designated an orphan drug for the control of gram-negative bacteria in the respiratory tract in cystic fibrosis patients in March 2002 and for the improvement of respiratory symptoms in patients with bronchiectasis and gram-negative bacteria in the airways in May 2009.

The FDA first approved aztreonam injection in December 1986. In February 2010, aztreonam for inhalation received FDA approval for improvement of respiratory symptoms in cystic fibrosis patients >= 7 years old with Pseudomonas aeruginosa.

Indications

  1. Aeromonas hydrophila
  2. bacteremia
  3. bronchitis
  4. burn wound infection
  5. Citrobacter freundii
  6. Citrobacter sp.
  7. community-acquired pneumonia
  8. cystic fibrosis
  9. cystitis
  10. diabetic foot ulcer
  11. endometritis
  12. Enterobacter cloacae
  13. Enterobacter sp.
  14. Escherichia coli
  15. febrile neutropenia
  16. gynecologic infections
  17. Haemophilus influenzae (beta-lactamase negative)
  18. Haemophilus influenzae (beta-lactamase positive)
  19. intraabdominal infections
  20. Klebsiella oxytoca
  21. Klebsiella pneumoniae
  22. lower respiratory tract infections
  23. Morganella morganii
  24. Neisseria gonorrhoeae
  25. Neisseria meningitidis
  26. nosocomial pneumonia
  27. Pasteurella multocida
  28. pelvic cellulitis
  29. peritonitis
  30. pneumonia
  31. Proteus mirabilis
  32. Proteus vulgaris
  33. Providencia rettgeri
  34. Providencia sp.
  35. Providencia stuartii
  36. Pseudomonas aeruginosa
  37. Pseudomonas sp.
  38. pyelonephritis
  39. Serratia marcescens
  40. Serratia sp.
  41. Shigella sp.
  42. skin and skin structure infections
  43. surgical infection prophylaxis
  44. urinary tract infection (UTI)
  45. Yersinia enterocolitica

Side Effects

  1. abdominal pain
  2. anaphylactoid reactions
  3. anemia
  4. angioedema
  5. arthralgia
  6. bronchospasm
  7. candidiasis
  8. chest pain (unspecified)
  9. confusion
  10. cough
  11. diaphoresis
  12. diarrhea
  13. diplopia
  14. dizziness
  15. dysgeusia
  16. dyspnea
  17. elevated hepatic enzymes
  18. encephalopathy
  19. eosinophilia
  20. erythema
  21. erythema multiforme
  22. exfoliative dermatitis
  23. fever
  24. flushing
  25. GI bleeding
  26. halitosis
  27. headache
  28. hepatitis
  29. hypotension
  30. injection site reaction
  31. insomnia
  32. jaundice
  33. leukocytosis
  34. malaise
  35. nasal congestion
  36. nausea
  37. neutropenia
  38. oral ulceration
  39. pancytopenia
  40. paresthesias
  41. petechiae
  42. phlebitis
  43. premature ventricular contractions (PVCs)
  44. pseudomembranous colitis
  45. purpura
  46. rash
  47. seizures
  48. sneezing
  49. superinfection
  50. thrombocytopenia
  51. thrombocytosis
  52. tinnitus
  53. toxic epidermal necrolysis
  54. urticaria
  55. vaginitis
  56. vertigo
  57. vomiting
  58. weakness
  59. wheezing

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN

Contraindications

  • acute bronchospasm
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • children
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection

Interactions

  • Oral Contraceptives
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top