Cefprozil Brand Name– Cefzil
What is Cefprozil
Cefprozil is an oral, semisynthetic, second-generation cephalosporin. In general, second-generation cephalosporins are more active and have a broader spectrum against gram-negative species than do the earlier generations of cephalosporins.
Therapeutic uses of cefprozil include otitis media, soft-tissue infections, and respiratory tract infections.
Cefprozil was approved by the FDA in December 1991.
Indications
- bronchitis
- Citrobacter diversus
- Clostridium difficile
- Clostridium perfringens
- Enterococcus durans
- Enterococcus faecalis
- Escherichia coli
- Fusobacterium sp.
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Klebsiella pneumoniae
- Listeria monocytogenes
- Moraxella catarrhalis
- Neisseria gonorrhoeae
- otitis media
- Peptostreptococcus sp.
- pharyngitis
- Prevotella melaninogenica
- Propionibacterium acnes
- Proteus mirabilis
- Salmonella sp.
- Shigella sp.
- sinusitis
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus epidermidis
- Staphylococcus saprophyticus
- Staphylococcus warneri
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp. (Group C)
- Streptococcus sp. (Group D)
- Streptococcus sp. (Group F)
- Streptococcus sp. (Group G)
- tonsillitis
- urinary tract infection (UTI)
- Vibrio sp.
- Viridans streptococci
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angioedema
- aplastic anemia
- bleeding
- colitis
- confusion
- diarrhea
- dizziness
- drowsiness
- elevated hepatic enzymes
- eosinophilia
- erythema multiforme
- fever
- headache
- hemolytic anemia
- hyperbilirubinemia
- insomnia
- interstitial nephritis
- jaundice
- leukopenia
- nausea
- neutropenia
- pancytopenia
- prolonged bleeding time
- pruritus
- pseudomembranous colitis
- rash
- seizures
- serum sickness
- Stevens-Johnson syndrome
- superinfection
- thrombocytopenia
- toxic epidermal necrolysis
- urticaria
- vaginitis
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- neonates
- penicillin hypersensitivity
- phenylketonuria
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- ulcerative colitis
- vitamin K deficiency
Interactions
- Amikacin
- Aminoglycosides
- Colchicine; Probenecid
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Gentamicin
- Kanamycin
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Mestranol; Norethindrone
- Norethindrone
- Norgestrel
- Oral Contraceptives
- Paromomycin
- Plazomicin
- Probenecid
- Segesterone Acetate; Ethinyl Estradiol
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Streptomycin
- Tobramycin
- Warfarin
