Cefprozil

Cefprozil Brand Name– Cefzil

What is Cefprozil

Cefprozil is an oral, semisynthetic, second-generation cephalosporin. In general, second-generation cephalosporins are more active and have a broader spectrum against gram-negative species than do the earlier generations of cephalosporins.

Therapeutic uses of cefprozil include otitis media, soft-tissue infections, and respiratory tract infections.

Cefprozil was approved by the FDA in December 1991.

Indications

  1. bronchitis
  2. Citrobacter diversus
  3. Clostridium difficile
  4. Clostridium perfringens
  5. Enterococcus durans
  6. Enterococcus faecalis
  7. Escherichia coli
  8. Fusobacterium sp.
  9. Haemophilus influenzae (beta-lactamase negative)
  10. Haemophilus influenzae (beta-lactamase positive)
  11. Klebsiella pneumoniae
  12. Listeria monocytogenes
  13. Moraxella catarrhalis
  14. Neisseria gonorrhoeae
  15. otitis media
  16. Peptostreptococcus sp.
  17. pharyngitis
  18. Prevotella melaninogenica
  19. Propionibacterium acnes
  20. Proteus mirabilis
  21. Salmonella sp.
  22. Shigella sp.
  23. sinusitis
  24. skin and skin structure infections
  25. Staphylococcus aureus (MSSA)
  26. Staphylococcus epidermidis
  27. Staphylococcus saprophyticus
  28. Staphylococcus warneri
  29. Streptococcus agalactiae (group B streptococci)
  30. Streptococcus pneumoniae
  31. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  32. Streptococcus sp. (Group C)
  33. Streptococcus sp. (Group D)
  34. Streptococcus sp. (Group F)
  35. Streptococcus sp. (Group G)
  36. tonsillitis
  37. urinary tract infection (UTI)
  38. Vibrio sp.
  39. Viridans streptococci

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. angioedema
  5. aplastic anemia
  6. bleeding
  7. colitis
  8. confusion
  9. diarrhea
  10. dizziness
  11. drowsiness
  12. elevated hepatic enzymes
  13. eosinophilia
  14. erythema multiforme
  15. fever
  16. headache
  17. hemolytic anemia
  18. hyperbilirubinemia
  19. insomnia
  20. interstitial nephritis
  21. jaundice
  22. leukopenia
  23. nausea
  24. neutropenia
  25. pancytopenia
  26. prolonged bleeding time
  27. pruritus
  28. pseudomembranous colitis
  29. rash
  30. seizures
  31. serum sickness
  32. Stevens-Johnson syndrome
  33. superinfection
  34. thrombocytopenia
  35. toxic epidermal necrolysis
  36. urticaria
  37. vaginitis
  38. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • neonates
  • penicillin hypersensitivity
  • phenylketonuria
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Amikacin
  • Aminoglycosides
  • Colchicine; Probenecid
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Gentamicin
  • Kanamycin
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Norethindrone
  • Norgestrel
  • Oral Contraceptives
  • Paromomycin
  • Plazomicin
  • Probenecid
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptomycin
  • Tobramycin
  • Warfarin
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