Ampicillin

Ampicillin Brand Name– Principen

What is Ampicillin

Ampicillin is classified as an aminopenicillin.

The aminopenicillins, a group that includes amoxicillin, are able to penetrate gram-negative bacteria more readily than are the natural penicillins or penicillinase-resistant penicillins.

However, the aminopenicillins are not stable to beta-lactamases of either gram-positive or gram-negative bacteria. In combination with sulbactam (a beta-lactamase inhibitor), ampicillin’s spectrum is broadened to include many of these beta-lactamase-producing organisms (see Ampicillin; Sulbactam monograph). Ampicillin is used primarily to treat infections such as otitis media, sinusitis, and acute bacterial cystitis caused by susceptible organisms.

Due to the increasing prevalence of resistant strains of N. gonorrhoeae, aminopenicillins are no longer recommended for the treatment of gonorrhea. Compared with amoxicillin, oral ampicillin has a lower bioavailability and is more likely to cause adverse GI effects.

Ampicillin trihydrate was approved by the FDA in 1963; ampicillin sodium was approved by the FDA in 1965.

Indications

  1. Actinomyces sp.
  2. anthrax
  3. appendicitis
  4. Bacillus anthracis
  5. bacteremia
  6. Bacteroides funduliformis
  7. Bifidobacterium sp.
  8. Bordetella pertussis
  9. Borrelia burgdorferi
  10. Brucella sp.
  11. cellulitis
  12. Clostridium sp.
  13. community-acquired pneumonia
  14. Corynebacterium diphtheriae
  15. Corynebacterium xerosis
  16. cystitis
  17. Eikenella corrodens
  18. endocarditis
  19. endocarditis prophylaxis
  20. Enterococcus sp.
  21. enterocolitis
  22. Erysipelothrix rhusiopathiae
  23. Escherichia coli
  24. Eubacterium sp.
  25. Gardnerella vaginalis
  26. gastroenteritis
  27. Haemophilus influenzae (beta-lactamase negative)
  28. Helicobacter pylori
  29. intraabdominal infections
  30. Klebsiella granulomatis
  31. Lactobacillus sp.
  32. Leptospira sp.
  33. leptospirosis
  34. Listeria monocytogenes
  35. lower respiratory tract infections
  36. meningitis
  37. Moraxella catarrhalis
  38. Neisseria gonorrhoeae
  39. Neisseria meningitidis
  40. Pasteurella multocida
  41. Peptococcus sp.
  42. Peptostreptococcus sp.
  43. perinatal Group B streptococcal infection prophylaxis
  44. peritonitis
  45. preterm premature rupture of membranes
  46. Propionibacterium sp.
  47. Proteus mirabilis
  48. pyelonephritis
  49. Salmonella sp.
  50. Salmonella typhi
  51. salmonellosis
  52. Shigella sp.
  53. shigellosis
  54. skin and skin structure infections
  55. Staphylococcus sp.
  56. Streptococcus agalactiae (group B streptococci)
  57. Streptococcus dysgalactiae
  58. Streptococcus pneumoniae
  59. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  60. Streptococcus sp.
  61. surgical infection prophylaxis
  62. Treponema pallidum
  63. typhoid fever
  64. upper respiratory tract infections
  65. urinary tract infection (UTI)
  66. Viridans streptococci

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. diarrhea
  8. dysphagia
  9. elevated hepatic enzymes
  10. enterocolitis
  11. eosinophilia
  12. erythema multiforme
  13. esophagitis
  14. exfoliative dermatitis
  15. fever
  16. glossitis
  17. Jarisch-Herxheimer reaction
  18. leukopenia
  19. maculopapular rash
  20. nausea
  21. odynophagia
  22. platelet dysfunction
  23. prolonged bleeding time
  24. pruritus
  25. pseudomembranous colitis
  26. rash
  27. seizures
  28. serum sickness
  29. stomatitis
  30. superinfection
  31. thrombocytopenia
  32. thrombotic thrombocytopenic purpura (TTP)
  33. tongue discoloration
  34. urticaria
  35. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • antimicrobial resistance
  • asthma
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • colitis
  • dialysis
  • diarrhea
  • eczema
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • mononucleosis
  • neonates
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal failure
  • renal impairment
  • serious rash
  • sexually transmitted disease
  • ulcerative colitis
  • urticaria

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Allopurinol
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atenolol
  • Atenolol; Chlorthalidone
  • Carbidopa; Levodopa; Entacapone
  • Chloroquine
  • Choline Salicylate; Magnesium Salicylate
  • Colchicine; Probenecid
  • Dexlansoprazole
  • Dichlorphenamide
  • Dienogest; Estradiol valerate
  • Digoxin
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Entacapone
  • Erythromycin; Sulfisoxazole
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethacrynic Acid
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Furosemide
  • Hydroxychloroquine
  • Indomethacin
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lesinurad; Allopurinol
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Magnesium Salicylate
  • Mestranol; Norethindrone
  • Methotrexate
  • Norethindrone
  • Norgestrel
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Pantoprazole
  • Probenecid
  • Proton pump inhibitors
  • Pyrimethamine; Sulfadoxine
  • Rabeprazole
  • Salsalate
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Benzoate; Sodium Phenylacetate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sulfadiazine
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfasalazine
  • Sulfisoxazole
  • Sulfonamides
  • Tetracyclines
  • Typhoid Vaccine
  • Warfarin
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top