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Ceftaroline fosamil Brand Name– Teflaro
What is Ceftaroline fosamil
Ceftaroline fosamil is an intravenous cephalosporin approved for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia.
It is a semi-synthetic, broad-spectrum antibiotic.
Ceftaroline is the first cephalosporin to be active against resistant gram-positive pathogens including methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), vancomycin-insensitive S. aureus (VISA), and hetero-resistant vancomycin-insensitive S. aureus (hVISA).
Indications
- Citrobacter freundii
- Citrobacter koseri
- community-acquired pneumonia
- Enterobacter cloacae
- Escherichia coli
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella aerogenes
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Moraxella catarrhalis
- Morganella morganii
- pneumonia
- Proteus mirabilis
- sepsis
- skin and skin structure infections
- Staphylococcus aureus (MRSA)
- Staphylococcus aureus (MSSA)
- Streptococcus agalactiae (group B streptococci)
- Streptococcus dysgalactiae
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anemia
- bradycardia
- constipation
- diarrhea
- dizziness
- elevated hepatic enzymes
- eosinophilia
- fever
- headache
- hepatitis
- hyperglycemia
- hyperkalemia
- hypokalemia
- leukopenia
- nausea
- neutropenia
- palpitations
- phlebitis
- pruritus
- pseudomembranous colitis
- rash
- renal failure (unspecified)
- seizures
- thrombocytopenia
- urticaria
- vomiting
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- antimicrobial resistance
- breast-feeding
- carbapenem hypersensitivity
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- dialysis
- diarrhea
- geriatric
- GI disease
- hypoprothrombinemia
- inflammatory bowel disease
- penicillin hypersensitivity
- pregnancy
- pseudomembranous colitis
- renal failure
- renal impairment
- ulcerative colitis
- viral infection
- vitamin K deficiency
Interactions
- Loop diuretics
- Oral Contraceptives
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
