Ceftaroline fosamil

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Ceftaroline fosamil Brand Name– Teflaro

What is Ceftaroline fosamil

Ceftaroline fosamil is an intravenous cephalosporin approved for the treatment of acute bacterial skin and skin structure infections and community-acquired bacterial pneumonia.

It is a semi-synthetic, broad-spectrum antibiotic.

Ceftaroline is the first cephalosporin to be active against resistant gram-positive pathogens including methicillin-resistant S. aureus (MRSA), vancomycin-resistant S. aureus (VRSA), vancomycin-insensitive S. aureus (VISA), and hetero-resistant vancomycin-insensitive S. aureus (hVISA).

Indications

  1. Citrobacter freundii
  2. Citrobacter koseri
  3. community-acquired pneumonia
  4. Enterobacter cloacae
  5. Escherichia coli
  6. Haemophilus influenzae (beta-lactamase negative)
  7. Haemophilus influenzae (beta-lactamase positive)
  8. Haemophilus parainfluenzae
  9. Klebsiella aerogenes
  10. Klebsiella oxytoca
  11. Klebsiella pneumoniae
  12. Moraxella catarrhalis
  13. Morganella morganii
  14. pneumonia
  15. Proteus mirabilis
  16. sepsis
  17. skin and skin structure infections
  18. Staphylococcus aureus (MRSA)
  19. Staphylococcus aureus (MSSA)
  20. Streptococcus agalactiae (group B streptococci)
  21. Streptococcus dysgalactiae
  22. Streptococcus pneumoniae
  23. Streptococcus pyogenes (group A beta-hemolytic streptococci)

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anemia
  5. bradycardia
  6. constipation
  7. diarrhea
  8. dizziness
  9. elevated hepatic enzymes
  10. eosinophilia
  11. fever
  12. headache
  13. hepatitis
  14. hyperglycemia
  15. hyperkalemia
  16. hypokalemia
  17. leukopenia
  18. nausea
  19. neutropenia
  20. palpitations
  21. phlebitis
  22. pruritus
  23. pseudomembranous colitis
  24. rash
  25. renal failure (unspecified)
  26. seizures
  27. thrombocytopenia
  28. urticaria
  29. vomiting

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • antimicrobial resistance
  • breast-feeding
  • carbapenem hypersensitivity
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • dialysis
  • diarrhea
  • geriatric
  • GI disease
  • hypoprothrombinemia
  • inflammatory bowel disease
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • ulcerative colitis
  • viral infection
  • vitamin K deficiency

Interactions

  • Loop diuretics
  • Oral Contraceptives
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin

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