Cefpodoxime proxetil

Cefpodoxime proxetil Brand Name– Vantin

What is Cefpodoxime proxetil

Cefpodoxime proxetil is an oral prodrug for the extended-spectrum, semi-synthetic cephalosporin antibiotic cefpodoxime.

The spectrum of cefpodoxime is similar to third-generation cephalosporins and has mainly gram-negative coverage, but also covers some gram-positive organisms.

The drug is highly stable in the presence of beta-lactamase enzymes, as a result, many organisms resistant to penicillins and some cephalosporins (due to beta-lactamases) may be susceptible to cefpodoxime.

Cefpodoxime is indicated for the treatment of upper and lower respiratory tract infections, urinary tract infections, sexually transmitted diseases, and skin and skin structure infections.

Cefpodoxime has a long half-life, allowing twice-daily administration.

This drug was approved by the FDA in 1984.

Indications

  1. bronchitis
  2. cervicitis
  3. Citrobacter diversus
  4. community-acquired pneumonia
  5. cystitis
  6. Escherichia coli
  7. gonorrhea
  8. Haemophilus influenzae (beta-lactamase negative)
  9. Haemophilus influenzae (beta-lactamase positive)
  10. Haemophilus parainfluenzae
  11. Klebsiella oxytoca
  12. Klebsiella pneumoniae
  13. Moraxella catarrhalis
  14. Neisseria gonorrhoeae
  15. otitis media
  16. Peptostreptococcus magnus
  17. pharyngitis
  18. pneumonia
  19. proctitis
  20. Proteus mirabilis
  21. Proteus vulgaris
  22. Providencia rettgeri
  23. sinusitis
  24. skin and skin structure infections
  25. Staphylococcus aureus (MSSA)
  26. Staphylococcus saprophyticus
  27. Streptococcus agalactiae (group B streptococci)
  28. Streptococcus pneumoniae
  29. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  30. Streptococcus sp. (Group C)
  31. Streptococcus sp. (Group F)
  32. Streptococcus sp. (Group G)
  33. tonsillitis
  34. urethritis
  35. urinary tract infection (UTI)

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactic shock
  4. anemia
  5. angioedema
  6. anorexia
  7. anxiety
  8. aplastic anemia
  9. bleeding
  10. candidiasis
  11. chest pain (unspecified)
  12. cholestasis
  13. confusion
  14. constipation
  15. cough
  16. diarrhea
  17. dizziness
  18. dysgeusia
  19. dyspepsia
  20. elevated hepatic enzymes
  21. eosinophilia
  22. epistaxis
  23. eructation
  24. exfoliative dermatitis
  25. fatigue
  26. fever
  27. flatulence
  28. gastritis
  29. hallucinations
  30. headache
  31. hemolytic anemia
  32. hypotension
  33. insomnia
  34. interstitial nephritis
  35. irritability
  36. leukocytosis
  37. leukopenia
  38. malaise
  39. menstrual irregularity
  40. nausea
  41. nightmares
  42. ocular irritation
  43. pancytopenia
  44. paresthesias
  45. pruritus
  46. pseudomembranous colitis
  47. rhinitis
  48. seizures
  49. skin irritation
  50. stomatitis
  51. superinfection
  52. syncope
  53. tenesmus
  54. thrombocytosis
  55. tinnitus
  56. urticaria
  57. vaginitis
  58. vertigo
  59. vomiting
  60. xerostomia

Monitoring Parameters

  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • geriatric
  • GI disease
  • infants
  • inflammatory bowel disease
  • labor
  • neonates
  • penicillin hypersensitivity
  • phenylketonuria
  • pregnancy
  • pseudomembranous colitis
  • renal disease
  • renal impairment
  • sexually transmitted disease
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Antacids
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Omeprazole
  • Calcium Carbonate
  • Calcium Carbonate; Magnesium Hydroxide
  • Calcium Carbonate; Risedronate
  • Calcium Carbonate; Simethicone
  • Cimetidine
  • Colchicine; Probenecid
  • Dexlansoprazole
  • Didanosine, ddI
  • Dienogest; Estradiol valerate
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Elagolix; Estradiol; Norethindrone acetate
  • Esomeprazole
  • Esomeprazole; Naproxen
  • Estradiol; Levonorgestrel
  • Estradiol; Norethindrone
  • Estradiol; Norgestimate
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Famotidine
  • Famotidine; Ibuprofen
  • H2-blockers
  • Lansoprazole
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Leuprolide; Norethindrone
  • Levonorgestrel
  • Loop diuretics
  • Mestranol; Norethindrone
  • Nizatidine
  • Norethindrone
  • Norgestrel
  • Omeprazole
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oral Contraceptives
  • Pantoprazole
  • Probenecid
  • Proton pump inhibitors
  • Rabeprazole
  • Ranitidine
  • Segesterone Acetate; Ethinyl Estradiol
  • Sodium Bicarbonate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Warfarin
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