Cefpodoxime proxetil Brand Name– Vantin
What is Cefpodoxime proxetil
Cefpodoxime proxetil is an oral prodrug for the extended-spectrum, semi-synthetic cephalosporin antibiotic cefpodoxime.
The spectrum of cefpodoxime is similar to third-generation cephalosporins and has mainly gram-negative coverage, but also covers some gram-positive organisms.
The drug is highly stable in the presence of beta-lactamase enzymes, as a result, many organisms resistant to penicillins and some cephalosporins (due to beta-lactamases) may be susceptible to cefpodoxime.
Cefpodoxime is indicated for the treatment of upper and lower respiratory tract infections, urinary tract infections, sexually transmitted diseases, and skin and skin structure infections.
Cefpodoxime has a long half-life, allowing twice-daily administration.
This drug was approved by the FDA in 1984.
Indications
- bronchitis
- cervicitis
- Citrobacter diversus
- community-acquired pneumonia
- cystitis
- Escherichia coli
- gonorrhea
- Haemophilus influenzae (beta-lactamase negative)
- Haemophilus influenzae (beta-lactamase positive)
- Haemophilus parainfluenzae
- Klebsiella oxytoca
- Klebsiella pneumoniae
- Moraxella catarrhalis
- Neisseria gonorrhoeae
- otitis media
- Peptostreptococcus magnus
- pharyngitis
- pneumonia
- proctitis
- Proteus mirabilis
- Proteus vulgaris
- Providencia rettgeri
- sinusitis
- skin and skin structure infections
- Staphylococcus aureus (MSSA)
- Staphylococcus saprophyticus
- Streptococcus agalactiae (group B streptococci)
- Streptococcus pneumoniae
- Streptococcus pyogenes (group A beta-hemolytic streptococci)
- Streptococcus sp. (Group C)
- Streptococcus sp. (Group F)
- Streptococcus sp. (Group G)
- tonsillitis
- urethritis
- urinary tract infection (UTI)
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactic shock
- anemia
- angioedema
- anorexia
- anxiety
- aplastic anemia
- bleeding
- candidiasis
- chest pain (unspecified)
- cholestasis
- confusion
- constipation
- cough
- diarrhea
- dizziness
- dysgeusia
- dyspepsia
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- eructation
- exfoliative dermatitis
- fatigue
- fever
- flatulence
- gastritis
- hallucinations
- headache
- hemolytic anemia
- hypotension
- insomnia
- interstitial nephritis
- irritability
- leukocytosis
- leukopenia
- malaise
- menstrual irregularity
- nausea
- nightmares
- ocular irritation
- pancytopenia
- paresthesias
- pruritus
- pseudomembranous colitis
- rhinitis
- seizures
- skin irritation
- stomatitis
- superinfection
- syncope
- tenesmus
- thrombocytosis
- tinnitus
- urticaria
- vaginitis
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- serum creatinine/BUN
Contraindications
- breast-feeding
- cephalosporin hypersensitivity
- coagulopathy
- colitis
- diarrhea
- geriatric
- GI disease
- infants
- inflammatory bowel disease
- labor
- neonates
- penicillin hypersensitivity
- phenylketonuria
- pregnancy
- pseudomembranous colitis
- renal disease
- renal impairment
- sexually transmitted disease
- ulcerative colitis
- vitamin K deficiency
Interactions
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Antacids
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Omeprazole
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Cimetidine
- Colchicine; Probenecid
- Dexlansoprazole
- Didanosine, ddI
- Dienogest; Estradiol valerate
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Elagolix; Estradiol; Norethindrone acetate
- Esomeprazole
- Esomeprazole; Naproxen
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Famotidine
- Famotidine; Ibuprofen
- H2-blockers
- Lansoprazole
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Leuprolide; Norethindrone
- Levonorgestrel
- Loop diuretics
- Mestranol; Norethindrone
- Nizatidine
- Norethindrone
- Norgestrel
- Omeprazole
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oral Contraceptives
- Pantoprazole
- Probenecid
- Proton pump inhibitors
- Rabeprazole
- Ranitidine
- Segesterone Acetate; Ethinyl Estradiol
- Sodium Bicarbonate
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Warfarin
