Cefotetan

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Cefotetan Brand Name– Cefotan

What is Cefotetan

Cefotetan is a parenteral cephamycin antibiotic that is classified as a second-generation cephalosporin. Other second-generation cephamycins include cefoxitin and cefmetazole.

Cefotetan differs from most other cephalosporins in its activity against anaerobic organisms, particularly B. fragilis. It also has a somewhat longer half-life, allowing for twice-daily dosing, compared with cefoxitin which requires usual dosing of 4 times daily.

Therapeutic uses include abdominal and soft-tissue infections, respiratory tract infections, and urinary tract infections.

Cefotetan was FDA-approved in December 1985.

Indications

  1. Bacteroides fragilis
  2. Bacteroides splanchnicus
  3. Bacteroides vulgatus
  4. bone and joint infections
  5. Citrobacter freundii
  6. Citrobacter koseri
  7. Citrobacter sp.
  8. Clostridium sp.
  9. Escherichia coli
  10. Fusobacterium sp.
  11. gynecologic infections
  12. Haemophilus influenzae (beta-lactamase negative)
  13. Haemophilus influenzae (beta-lactamase positive)
  14. intraabdominal infections
  15. Klebsiella pneumoniae
  16. Klebsiella sp.
  17. lower respiratory tract infections
  18. Moraxella catarrhalis
  19. Morganella morganii
  20. Neisseria gonorrhoeae
  21. pelvic inflammatory disease (PID)
  22. Peptococcus niger
  23. Peptostreptococcus sp.
  24. Porphyromonas asaccharolytica
  25. Prevotella bivia
  26. Prevotella disiens
  27. Prevotella melaninogenica
  28. Prevotella oralis
  29. Propionibacterium sp.
  30. Proteus mirabilis
  31. Proteus vulgaris
  32. Providencia rettgeri
  33. Salmonella sp.
  34. Serratia marcescens
  35. Serratia sp.
  36. Shigella sp.
  37. skin and skin structure infections
  38. Staphylococcus aureus (MSSA)
  39. Staphylococcus epidermidis
  40. Streptococcus agalactiae (group B streptococci)
  41. Streptococcus pneumoniae
  42. Streptococcus pyogenes (group A beta-hemolytic streptococci)
  43. Streptococcus sp.
  44. surgical infection prophylaxis
  45. tubo-ovarian abscess
  46. urinary tract infection (UTI)
  47. Veillonella sp.
  48. Yersinia enterocolitica

Side Effects

  1. abdominal pain
  2. agranulocytosis
  3. anaphylactoid reactions
  4. angioedema
  5. aplastic anemia
  6. azotemia
  7. bleeding
  8. candidiasis
  9. cholestasis
  10. colitis
  11. diarrhea
  12. elevated hepatic enzymes
  13. eosinophilia
  14. erythema multiforme
  15. fever
  16. hemolytic anemia
  17. hyperbilirubinemia
  18. injection site reaction
  19. interstitial nephritis
  20. leukopenia
  21. nausea
  22. neutropenia
  23. pancytopenia
  24. phlebitis
  25. pruritus
  26. pseudomembranous colitis
  27. rash
  28. seizures
  29. Stevens-Johnson syndrome
  30. superinfection
  31. thrombocytopenia
  32. thrombocytosis
  33. toxic epidermal necrolysis
  34. urticaria
  35. vaginitis
  36. vomiting

Monitoring Parameters

  • prothrombin time (PT)
  • serum creatinine/BUN

Contraindications

  • breast-feeding
  • cephalosporin hypersensitivity
  • coagulopathy
  • colitis
  • diarrhea
  • ethanol ingestion
  • geriatric
  • GI disease
  • hemolytic anemia
  • inflammatory bowel disease
  • penicillin hypersensitivity
  • pregnancy
  • pseudomembranous colitis
  • renal failure
  • renal impairment
  • sexually transmitted disease
  • ulcerative colitis
  • vitamin K deficiency

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Amikacin
  • Aminoglycosides
  • Aminosalicylate sodium, Aminosalicylic acid
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Choline Salicylate; Magnesium Salicylate
  • Diflunisal
  • Ethanol
  • Gentamicin
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Kanamycin
  • Loop diuretics
  • Magnesium Salicylate
  • Oral Contraceptives
  • Paromomycin
  • Plazomicin
  • Salicylates
  • Salsalate
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Streptomycin
  • Tobramycin
  • Warfarin

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