Acetaminophen and Caffeine

Acetaminophen and Caffeine Brand Name

Excedrin Mild Headache | Excedrin Quick Tabs | Excedrin Tension Headache | Excedrin Tension Headache Express | Goody’s Headache Relief

What is Acetaminophen and Caffeine

Acetaminophen; caffeine is an oral analgesic indicated for the relief of mild pain due to cold and flu, dental pain, headache, myalgia, osteoarthritis, or sore throat.

Caffeine is included to enhance analgesic efficacy.

Acetaminophen possesses analgesic and antipyretic activity similar to aspirin; however, acetaminophen has no peripheral anti-inflammatory activity or effects on platelet function.

It is effective in the relief of both acute and chronic pain and may be preferred over nonsteroidal anti-inflammatory drugs (NSAIDs) in certain patients due to fewer hematologic, gastrointestinal, and renal effects.

Acetaminophen is the analgesic/antipyretic of choice for episodic use in patients with underlying renal disease; however, chronic use in this population is discouraged.

Acetaminophen has a history of safe and effective use; however, unintentional or intentional misuse of acetaminophen is the leading cause of acute hepatic failure in the U.S.

Indications

  • dental pain
  • headache
  • mild pain
  • myalgia
  • osteoarthritis

For the relief of mild pain due to cold and flu, dental pain, headache, myalgia, osteoarthritis, or sore throat

Side Effects

  1. acute generalized exanthematous pustulosis (AGEP)
  2. agranulocytosis
  3. anaphylactic shock
  4. anaphylactoid reactions
  5. anemia
  6. angioedema
  7. anorexia
  8. anxiety
  9. constipation
  10. contact dermatitis
  11. diarrhea
  12. dyspepsia
  13. elevated hepatic enzymes
  14. erythema
  15. exfoliative dermatitis
  16. gastroesophageal reflux
  17. headache
  18. hearing loss
  19. hemolysis
  20. hemolytic anemia
  21. hepatic encephalopathy
  22. hepatic failure
  23. hepatic necrosis
  24. hepatotoxicity
  25. hypercalciuria
  26. hyperglycemia
  27. hypoglycemia
  28. hypoprothrombinemia
  29. increased urinary frequency
  30. insomnia
  31. interstitial nephritis
  32. irritability
  33. jaundice
  34. maculopapular rash
  35. malaise
  36. nausea
  37. neutropenia
  38. palpitations
  39. pancytopenia
  40. polyuria
  41. purpura
  42. rash
  43. renal failure (unspecified)
  44. renal papillary necrosis
  45. renal tubular necrosis
  46. rhabdomyolysis
  47. seizures
  48. sinus tachycardia
  49. Stevens-Johnson syndrome
  50. thrombocytopenia
  51. thrombocytosis
  52. toxic epidermal necrolysis
  53. tremor
  54. urticaria
  55. vomiting
  56. withdrawal

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN: in chronic use or acute toxicity

Contraindications

  • acetaminophen hypersensitivity
  • alcoholism
  • anxiety
  • breast-feeding
  • cardiac disease
  • diabetes mellitus
  • ethanol intoxication
  • G6PD deficiency
  • gastroesophageal reflux disease (GERD)
  • geriatric
  • hepatic disease
  • hepatitis
  • hepatotoxicity
  • hyperthyroidism
  • hypovolemia
  • insomnia
  • malnutrition
  • potential for overdose or poisoning
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • tachycardia
  • tobacco smoking

Interactions

  • Abacavir; Lamivudine, 3TC; Zidovudine, ZDV
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Pseudoephedrine
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Adenosine
  • Albuterol
  • Albuterol; Ipratropium
  • Amantadine
  • Amiodarone
  • Amobarbital
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anagrelide
  • Antacids
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Armodafinil
  • Articaine; Epinephrine
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Benzodiazepines
  • Benzphetamine
  • Beta-agonists
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Boceprevir
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide; Formoterol
  • Bupivacaine
  • Bupivacaine Liposomal
  • Bupivacaine; Lidocaine
  • Bupropion
  • Bupropion; Naltrexone
  • Busulfan
  • Butabarbital
  • Caffeine
  • Cannabidiol
  • Capmatinib
  • Carbamazepine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Phenylephrine
  • Carbinoxamine; Pseudoephedrine
  • Cetirizine; Pseudoephedrine
  • Charcoal
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlophedianol; Guaifenesin; Phenylephrine
  • Chloroprocaine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cimetidine
  • Ciprofloxacin
  • Clozapine
  • Codeine; Phenylephrine; Promethazine
  • Dapsone
  • Darifenacin
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Desloratadine; Pseudoephedrine
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Diphenhydramine; Phenylephrine
  • Dextromethorphan; Guaifenesin; Phenylephrine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Diethylpropion
  • Diflunisal
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Phenylephrine
  • Dipyridamole
  • Disulfiram
  • Dobutamine
  • Dopamine
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Echinacea
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eltrombopag
  • Ephedrine
  • Epinephrine
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Esketamine
  • Eszopiclone
  • Ethanol
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Exenatide
  • Fesoterodine
  • Fexofenadine; Pseudoephedrine
  • Fluconazole
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Fluvoxamine
  • Formoterol
  • Formoterol; Mometasone
  • Givosiran
  • Glycopyrrolate; Formoterol
  • grapefruit juice
  • Green Tea
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Hydantoins
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydroxyprogesterone
  • Ibuprofen; Pseudoephedrine
  • Imatinib
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Insulin Glargine; Lixisenatide
  • Isavuconazonium
  • Isocarboxazid
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Isoproterenol
  • Ketoconazole
  • Ketoprofen
  • Lamivudine, 3TC; Zidovudine, ZDV
  • Lamotrigine
  • Lanthanum Carbonate
  • Levalbuterol
  • Lidocaine
  • Lidocaine; Prilocaine
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lixisenatide
  • Lomitapide
  • Lopinavir; Ritonavir
  • Loratadine; Pseudoephedrine
  • Magnesium Salicylate
  • Melatonin
  • Mephobarbital
  • Mepivacaine
  • Mepivacaine; Levonordefrin
  • Mestranol; Norethindrone
  • Metaproterenol
  • Methamphetamine
  • Methohexital
  • Methylphenidate
  • Metyrapone
  • Mexiletine
  • Midodrine
  • Mipomersen
  • Mitotane
  • Modafinil
  • Monoamine oxidase inhibitors
  • Naproxen; Pseudoephedrine
  • Non-Ionic Contrast Media
  • Norepinephrine
  • Obeticholic Acid
  • Olodaterol
  • Ombitasvir; Paritaprevir; Ritonavir
  • Omeprazole; Amoxicillin; Rifabutin
  • Omeprazole; Sodium Bicarbonate
  • Oxybutynin
  • Peginterferon Alfa-2b
  • Pemoline
  • Penicillin G Benzathine; Penicillin G Procaine
  • Penicillin G Procaine
  • Pentobarbital
  • Phendimetrazine
  • Phenelzine
  • Phenobarbital
  • Phentermine
  • Phentermine; Topiramate
  • Phenylephrine
  • Phenylephrine; Promethazine
  • Pirbuterol
  • Pneumococcal Vaccine, Polyvalent
  • Posaconazole
  • Pramlintide
  • Prilocaine
  • Prilocaine; Epinephrine
  • Primidone
  • Procarbazine
  • Pseudoephedrine
  • Racepinephrine
  • Ramelteon
  • Rasagiline
  • Regadenoson
  • Rifabutin
  • Rifampin
  • Ritodrine
  • Ritonavir
  • Ropivacaine
  • Rucaparib
  • Salmeterol
  • Salsalate
  • Secobarbital
  • Segesterone Acetate; Ethinyl Estradiol
  • Selegiline
  • Sodium Bicarbonate
  • Sodium Oxybate
  • Solifenacin
  • Solriamfetol
  • St. John’s Wort, Hypericum perforatum
  • Sulfinpyrazone
  • Suvorexant
  • Tasimelteon
  • Telaprevir
  • Telotristat Ethyl
  • Terbinafine
  • Terbutaline
  • Teriflunomide
  • Tetracaine
  • Theophylline, Aminophylline
  • Thiabendazole
  • Thiopental
  • Tiotropium; Olodaterol
  • Tizanidine
  • tobacco
  • Tolterodine
  • Trandolapril; Verapamil
  • Tranylcypromine
  • Trimetrexate
  • Umeclidinium; Vilanterol
  • Vemurafenib
  • Verapamil
  • Warfarin
  • Yohimbine
  • Zaleplon
  • Zidovudine, ZDV
  • Zileuton
  • Zolmitriptan
  • Zolpidem
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