Acetaminophen Caffeine Magnesium Salicylate Phenyltoloxamine

Acetaminophen Caffeine Magnesium Salicylate Phenyltoloxamine Brand Names

Cafgesic Forte | Combiflex ES | Durabac Forte

What is Acetaminophen Caffeine Magnesium Salicylate Phenyltoloxamine

Acetaminophen Caffeine Magnesium Salicylate Phenyltoloxamine is a prescription combination product used for the temporary relief of mild to moderate pain and discomfort associated with simple headache, musculoskeletal pain, spasms, neuralgia, sinusitis, minor menstrual cramps, the common cold or grippe, toothache, and rheumatism or arthritis.

Indications

  1. common cold
  2. dental pain
  3. headache
  4. muscle spasm
  5. osteoarthritis
  6. rheumatoid arthritis
  7. sinusitis

Side Effects

  1. acneiform rash
  2. agranulocytosis
  3. anaphylactoid reactions
  4. angioedema
  5. anorexia
  6. anxiety
  7. aplastic anemia
  8. asthenia
  9. AV block
  10. azotemia
  11. blurred vision
  12. bronchial secretions
  13. bronchospasm
  14. confusion
  15. cyanosis
  16. dehydration
  17. diaphoresis
  18. diarrhea
  19. disseminated intravascular coagulation (DIC)
  20. dizziness
  21. drowsiness
  22. dyspepsia
  23. ecchymosis
  24. edema
  25. elevated hepatic enzymes
  26. encephalopathy
  27. erythema
  28. erythema nodosum
  29. excitability
  30. exfoliative dermatitis
  31. fever
  32. flushing
  33. hallucinations
  34. headache
  35. heart failure
  36. hemolytic anemia
  37. hepatic necrosis
  38. hepatitis
  39. hyperbilirubinemia
  40. hypercalciuria
  41. hyperglycemia
  42. hypermagnesemia
  43. hypernatremia
  44. hypertension
  45. hyperuricemia
  46. hyperventilation
  47. hypoglycemia
  48. hypokalemia
  49. hypotension
  50. insomnia
  51. interstitial nephritis
  52. irritability
  53. jaundice
  54. lethargy
  55. leukocytosis
  56. leukopenia
  57. maculopapular rash
  58. methemoglobinemia
  59. mydriasis
  60. myocarditis
  61. nausea
  62. palpitations
  63. pancytopenia
  64. physiological dependence
  65. polydipsia
  66. proteinuria
  67. pruritus
  68. pulmonary edema
  69. purpura
  70. pyrosis (heartburn)
  71. rash
  72. renal failure (unspecified)
  73. renal papillary necrosis
  74. respiratory depression
  75. restlessness
  76. Reye’s syndrome
  77. seizures
  78. sinus tachycardia
  79. thrombocytopenia
  80. thrombocytosis
  81. thrombotic thrombocytopenic purpura (TTP)
  82. tinnitus
  83. toxic epidermal necrolysis
  84. tremor
  85. urinary retention
  86. urticaria
  87. visual impairment
  88. vomiting
  89. weakness
  90. wheezing
  91. xerophthalmia
  92. xerostomia

Monitoring Parameters

  • LFTs
  • serum creatinine/BUN: in chronic use or acute toxicity

Contraindications

  • acetaminophen hypersensitivity
  • acid/base imbalance
  • acute bronchospasm
  • alcoholism
  • anemia
  • angina
  • anticoagulant therapy
  • ascites
  • asthma
  • bladder obstruction
  • bone marrow suppression
  • breast-feeding
  • bronchitis
  • cardiac arrhythmias
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • dehydration
  • driving or operating machinery
  • emphysema
  • esophagitis
  • G6PD deficiency
  • gastritis
  • geriatric
  • GI bleeding
  • GI disease
  • GI obstruction
  • GI perforation
  • gout
  • heart failure
  • hemophilia
  • hepatic disease
  • hepatitis
  • hypermagnesemia
  • hypertension
  • hypoprothrombinemia
  • hypovolemia
  • ileus
  • immunosuppression
  • increased intraocular pressure
  • infants
  • influenza
  • labor
  • MAOI therapy
  • metabolic acidosis
  • metabolic alkalosis
  • myocardial infarction
  • nasal polyps
  • neonates
  • neutropenia
  • peptic ulcer disease
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • pyloric stenosis
  • renal disease
  • renal failure
  • renal impairment
  • respiratory acidosis
  • respiratory alkalosis
  • Reye’s syndrome
  • salicylate hypersensitivity
  • systemic lupus erythematosus (SLE)
  • thrombolytic therapy
  • thrombotic thrombocytopenic purpura (TTP)
  • tobacco smoking
  • ulcerative colitis
  • urinary retention
  • varicella
  • viral infection
  • vitamin K deficiency
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