Carbetapentane Pyrilamine

Carbetapentane Pyrilamine Brand Name– Pyrlex CB

What is Carbetapentane Pyrilamine

NOTE: These products are discontinued in the U.S.

Carbetapentane pyrilamine is an antitussive-antihistamine combination product.

These drugs are used together in an oral preparation to relieve cough due to respiratory tract conditions such as the common cold, bronchial asthma, and acute and chronic bronchitis.

Carbetapentane is a non-opioid, centrally acting cough suppressant.

Carbetapentane suppresses the cough reflex by direct action on the medullary cough center and also produces a drying effect on the respiratory mucus membranes.

Pyrilamine is a sedating antihistamine (H1-blocker) that dries nasal sinus passages secondary to its anticholinergic activity.

Indications

  • common cold
  • cough

For symptomatic relief of cough associated with bronchial asthma, acute and chronic bronchitis, and the common cold

Side Effects

  1. arrhythmia exacerbation
  2. ataxia
  3. blurred vision
  4. bronchial secretions
  5. constipation
  6. dizziness
  7. drowsiness
  8. hallucinations
  9. hypertension
  10. hypotension
  11. insomnia
  12. mydriasis
  13. nasal dryness
  14. nausea
  15. palpitations
  16. psychosis
  17. restlessness
  18. seizures
  19. sinus tachycardia
  20. urinary retention
  21. vomiting
  22. xerophthalmia
  23. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • asthma
  • bladder obstruction
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • diabetes mellitus
  • driving or operating machinery
  • geriatric
  • GI obstruction
  • heart failure
  • hypertension
  • hyperthyroidism
  • ileus
  • infants
  • MAOI therapy
  • neonates
  • phenylketonuria
  • pregnancy
  • prostatic hypertrophy
  • status asthmaticus
  • urinary retention

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Tramadol
  • Aldesleukin, IL-2
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Apraclonidine
  • Aripiprazole
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Butyrophenone
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlordiazepoxide; Clidinium
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Clobazam
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Dantrolene
  • Daratumumab; Hyaluronidase
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan; Promethazine
  • Dicyclomine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dronabinol
  • Entacapone
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Fentanyl
  • Flavoxate
  • Flibanserin
  • Fluphenazine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Heparin
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Indacaterol; Glycopyrrolate
  • Isocarboxazid
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Linezolid
  • Lithium
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methscopolamine
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Opiate Agonists
  • Opiate Agonists-Antagonists
  • Orphenadrine
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenothiazines
  • Phenylephrine; Promethazine
  • Pimozide
  • Pitolisant
  • Pramipexole
  • Pregabalin
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propantheline
  • Propofol
  • Propoxyphene
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Scopolamine
  • Sedating H1-blockers
  • Selegiline
  • Sincalide
  • Skeletal Muscle Relaxants
  • Sodium Iodide
  • Solifenacin
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tasimelteon
  • Tetrabenazine
  • Thalidomide
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tramadol
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trihexyphenidyl
  • Trimethobenzamide
  • Trospium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Zolpidem
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