Carbetapentane Pyrilamine Brand Name– Pyrlex CB
What is Carbetapentane Pyrilamine
NOTE: These products are discontinued in the U.S.
Carbetapentane pyrilamine is an antitussive-antihistamine combination product.
These drugs are used together in an oral preparation to relieve cough due to respiratory tract conditions such as the common cold, bronchial asthma, and acute and chronic bronchitis.
Carbetapentane is a non-opioid, centrally acting cough suppressant.
Carbetapentane suppresses the cough reflex by direct action on the medullary cough center and also produces a drying effect on the respiratory mucus membranes.
Pyrilamine is a sedating antihistamine (H1-blocker) that dries nasal sinus passages secondary to its anticholinergic activity.
Indications
- common cold
- cough
For symptomatic relief of cough associated with bronchial asthma, acute and chronic bronchitis, and the common cold
Side Effects
- arrhythmia exacerbation
- ataxia
- blurred vision
- bronchial secretions
- constipation
- dizziness
- drowsiness
- hallucinations
- hypertension
- hypotension
- insomnia
- mydriasis
- nasal dryness
- nausea
- palpitations
- psychosis
- restlessness
- seizures
- sinus tachycardia
- urinary retention
- vomiting
- xerophthalmia
- xerostomia
Monitoring Parameters
- laboratory monitoring not necessary
Contraindications
- asthma
- bladder obstruction
- breast-feeding
- cardiac arrhythmias
- cardiac disease
- cardiomyopathy
- children
- chronic obstructive pulmonary disease (COPD)
- closed-angle glaucoma
- contact lenses
- diabetes mellitus
- driving or operating machinery
- geriatric
- GI obstruction
- heart failure
- hypertension
- hyperthyroidism
- ileus
- infants
- MAOI therapy
- neonates
- phenylketonuria
- pregnancy
- prostatic hypertrophy
- status asthmaticus
- urinary retention
Interactions
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Codeine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pentazocine
- Acetaminophen; Propoxyphene
- Acetaminophen; Tramadol
- Aldesleukin, IL-2
- Alfentanil
- Alosetron
- Amantadine
- Ambenonium Chloride
- Amoxapine
- Amphetamine
- Amphetamine; Dextroamphetamine
- Amphetamine; Dextroamphetamine Salts
- Anticholinergics
- Anxiolytics; Sedatives; and Hypnotics
- Apraclonidine
- Aripiprazole
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atropine
- Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Atropine; Difenoxin
- Atropine; Diphenoxylate
- Atropine; Edrophonium
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- atypical antipsychotic
- Azelastine
- Azelastine; Fluticasone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Belladonna; Opium
- Benzodiazepines
- Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
- Benzphetamine
- Benztropine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butorphanol
- Butyrophenone
- Cannabidiol
- Capsaicin; Metaxalone
- Carbetapentane; Chlorpheniramine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carisoprodol
- Cenobamate
- Cetirizine
- Cetirizine; Pseudoephedrine
- Chlordiazepoxide; Clidinium
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpromazine
- Chlorzoxazone
- Clobazam
- Clozapine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- COMT inhibitors
- Dantrolene
- Daratumumab; Hyaluronidase
- Desloratadine
- Desloratadine; Pseudoephedrine
- Dexmedetomidine
- Dextroamphetamine
- Dextromethorphan; Promethazine
- Dicyclomine
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Dronabinol
- Entacapone
- Eszopiclone
- Ethanol
- Etomidate
- Fentanyl
- Flavoxate
- Flibanserin
- Fluphenazine
- Fospropofol
- Gabapentin
- Galantamine
- General anesthetics
- Glycopyrrolate
- Glycopyrrolate; Formoterol
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Halogenated Anesthetics
- Heparin
- Heterocyclic antidepressants
- Homatropine; Hydrocodone
- Hyaluronidase
- Hyaluronidase, Recombinant; Immune Globulin
- Hydantoins
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydromorphone
- Hyoscyamine
- Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
- Ibuprofen; Oxycodone
- Iloperidone
- Indacaterol; Glycopyrrolate
- Isocarboxazid
- Ketamine
- Lasmiditan
- Lemborexant
- Levocetirizine
- Levomethadyl
- Levorphanol
- Linezolid
- Lithium
- Loratadine
- Loratadine; Pseudoephedrine
- Loxapine
- Lumateperone
- Lurasidone
- Magnesium Salts
- Maprotiline
- Meclizine
- Melatonin
- Mepenzolate
- Meperidine
- Meperidine; Promethazine
- Meprobamate
- Metaxalone
- Methadone
- Methamphetamine
- Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
- Methocarbamol
- Methscopolamine
- Metoclopramide
- Metyrapone
- Metyrosine
- Minocycline
- Mirtazapine
- Mitotane
- Molindone
- Monoamine oxidase inhibitors
- Morphine
- Morphine; Naltrexone
- Nabilone
- Nalbuphine
- Nefazodone
- Opiate Agonists
- Opiate Agonists-Antagonists
- Orphenadrine
- Oxybutynin
- Oxycodone
- Oxymorphone
- Paliperidone
- Paroxetine
- Pentazocine
- Pentazocine; Naloxone
- Perampanel
- Perphenazine
- Perphenazine; Amitriptyline
- Phenelzine
- Phenothiazines
- Phenylephrine; Promethazine
- Pimozide
- Pitolisant
- Pramipexole
- Pregabalin
- Procarbazine
- Prochlorperazine
- Promethazine
- Propantheline
- Propofol
- Propoxyphene
- Ramelteon
- Rasagiline
- Remifentanil
- Risperidone
- Rituximab; Hyaluronidase
- Rivastigmine
- Ropinirole
- Safinamide
- Scopolamine
- Sedating H1-blockers
- Selegiline
- Sincalide
- Skeletal Muscle Relaxants
- Sodium Iodide
- Solifenacin
- Sufentanil
- Suvorexant
- Tacrine
- Tasimelteon
- Tetrabenazine
- Thalidomide
- Thioridazine
- Thiothixene
- Tizanidine
- Tolcapone
- Tramadol
- Tranylcypromine
- Trastuzumab; Hyaluronidase
- Trazodone
- Tricyclic antidepressants
- Trifluoperazine
- Trihexyphenidyl
- Trimethobenzamide
- Trospium
- Vigabatrin
- Vilazodone
- Zaleplon
- Ziconotide
- Zolpidem