Carbetapentane Phenylephrine Pyrilamine

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Carbetapentane Phenylephrine Pyrilamine Brand Names

C-Tanna 12D | Tannate 12D S | Tannihist-12 D | Tussi-12 D | Tussi-12 D S

What is Carbetapentane Phenylephrine Pyrilamine

NOTE: These products are discontinued in the U.S.

Carbetapentane phenylephrine; pyrilamine is an antitussive-decongestant-antihistamine combination product.

These drugs are used together in an oral preparation to relieve cough and histamine-mediated allergic symptoms, such as congestion, rhinorrhea, sneezing, and watery, itchy eyes.

Specifically, this combination is indicated for the relief of such symptoms due to the common cold, and acute and chronic bronchitis.

Carbetapentane is a non-opioid, centrally acting cough suppressant. Carbetapentane suppresses the cough reflex by direct action on the medullary cough center and also produces a drying effect on the respiratory mucus membranes.

Phenylephrine is a sympathomimetic agent that causes vasoconstriction and decreases nasal and sinus congestion.

Pyrilamine is a sedating antihistamine (H1-blocker) that dries nasal sinus passages secondary to its anticholinergic activity.

Indications

  1. allergic rhinitis
  2. bronchitis
  3. common cold
  4. cough
  5. nasal congestion

For symptomatic relief of cough associated with bronchial asthma, acute and chronic bronchitis, and the common cold; and for nasal congestion associated with seasonal and perennial allergic rhinitis, vasomotor rhinitis, or the common cold

Side Effects

  1. abdominal pain
  2. arrhythmia exacerbation
  3. ataxia
  4. blurred vision
  5. bradycardia
  6. confusion
  7. constipation
  8. dizziness
  9. drowsiness
  10. hallucinations
  11. headache
  12. hypertension
  13. hypotension
  14. impaired cognition
  15. insomnia
  16. mydriasis
  17. nasal dryness
  18. nausea
  19. palpitations
  20. psychosis
  21. restlessness
  22. seizures
  23. sinus tachycardia
  24. urinary retention
  25. vomiting
  26. weakness
  27. xerophthalmia
  28. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • angina
  • arteriosclerosis
  • asthma
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • bronchitis
  • bundle-branch block
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • emphysema
  • fever
  • geriatric
  • GI obstruction
  • head trauma
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intracranial pressure
  • infants
  • labor
  • MAOI therapy
  • neonates
  • obstetric delivery
  • peptic ulcer disease
  • peripheral vascular disease
  • pregnancy
  • prostatic hypertrophy
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • status asthmaticus
  • tartrazine dye hypersensitivity
  • thyroid disease
  • tobacco smoking
  • urinary retention
  • ventricular tachycardia

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amantadine
  • Ambenonium Chloride
  • Ambrisentan
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Apraclonidine
  • Arformoterol
  • Aripiprazole
  • Articaine; Epinephrine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Avanafil
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Baclofen
  • Barbiturates
  • Beclomethasone
  • Belladonna Alkaloids; Ergotamine; Phenobarbital
  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
  • Benztropine
  • Beta-blockers
  • Betamethasone
  • Betaxolol
  • Bethanechol
  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
  • Bretylium
  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Butyrophenone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Ciclesonide
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Corticosteroids
  • Cortisone
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Daratumumab; Hyaluronidase
  • Deflazacort
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Diazepam
  • Dicyclomine
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Dorzolamide; Timolol
  • Doxazosin
  • Dronabinol
  • Dulaglutide
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etomidate
  • Exenatide
  • Felodipine
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Flibanserin
  • Fludrocortisone
  • Flunisolide
  • Fluphenazine
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Furosemide
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
  • Ionic Contrast Media
  • Isocarboxazid
  • Isoflurane
  • Isradipine
  • Ketamine
  • Labetalol
  • Lasmiditan
  • Lemborexant
  • Levalbuterol
  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
  • Liothyronine
  • Liraglutide
  • Lithium
  • Lixisenatide
  • Loop diuretics
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Macitentan
  • Magnesium Salts
  • Maprotiline
  • Mecamylamine
  • Meclizine
  • Meglitinides
  • Melatonin
  • Mepenzolate
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaproterenol
  • Metaxalone
  • Metformin
  • Metformin; Pioglitazone
  • Metformin; Repaglinide
  • Metformin; Rosiglitazone
  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
  • Methamphetamine
  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
  • Methscopolamine
  • Methyclothiazide
  • Methyldopa
  • Methylergonovine
  • Methylphenidate
  • Methylprednisolone
  • Methysergide
  • Metoclopramide
  • Metolazone
  • Metoprolol
  • Metyrapone
  • Metyrosine
  • Midazolam
  • Midodrine
  • Miglitol
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Mometasone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nadolol
  • Nafarelin
  • Nalbuphine
  • Naproxen; Pseudoephedrine
  • Nebivolol
  • Nebivolol; Valsartan
  • Nefazodone
  • Nicardipine
  • Nicotine
  • Nifedipine
  • Nimodipine
  • Nisoldipine
  • Nitrates
  • Non-Ionic Contrast Media
  • Opiate Agonists
  • Opiate Agonists-Antagonists
  • Orphenadrine
  • Oxazepam
  • Oxybutynin
  • Oxycodone
  • Oxymorphone
  • Oxytocin
  • Ozanimod
  • Paliperidone
  • Paroxetine
  • Penbutolol
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Pergolide
  • Perindopril; Amlodipine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phendimetrazine
  • Phenelzine
  • Phenothiazines
  • Phenoxybenzamine
  • Phentermine
  • Phentermine; Topiramate
  • Phentolamine
  • Phenylephrine; Promethazine
  • Phosphodiesterase inhibitors
  • Pimozide
  • Pindolol
  • Pioglitazone
  • Pirbuterol
  • Pitolisant
  • Potassium-sparing diuretics
  • Pramipexole
  • Pramlintide
  • Prazosin
  • Prednisolone
  • Prednisone
  • Pregabalin
  • Prilocaine; Epinephrine
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propantheline
  • Propofol
  • Propoxyphene
  • Propranolol
  • Pseudoephedrine
  • Quazepam
  • Racepinephrine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Reserpine
  • Riociguat
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Rosiglitazone
  • Safinamide
  • Salmeterol
  • Scopolamine
  • Sedating H1-blockers
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  • Sevoflurane
  • SGLT2 Inhibitors
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  • Theophylline, Aminophylline
  • Thiazide diuretics
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  • Thyroid hormones
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  • Vardenafil
  • Vasodilators
  • Verapamil
  • Vigabatrin
  • Vilazodone
  • Yohimbine
  • Zaleplon
  • Ziconotide
  • Zolpidem

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