Carbidopa

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Carbidopa Brand Name– Lodosyn

What is Carbidopa

Carbidopa is a decarboxylase inhibitor that is used in combination with levodopa for the treatment of Parkinson’s disease.

The addition of carbidopa allows lower doses of levodopa to be used, allows for more rapid titration of and a smoother response to levodopa treatment, and minimizes certain adverse reactions attributed to levodopa therapy such as nausea and vomiting.

Patients with markedly irregular (on-off) responses to levodopa have not been shown to benefit from the addition of carbidopa.

The FDA approved carbidopa prior to 1982; however, carbidopa had been available to prescribers only through a compassionate use program.

Beginning in December 1999, carbidopa became available to US pharmacies for distribution.

Indications

  • Parkinson’s disease
  • parkinsonism

For the treatment of idiopathic Parkinson’s disease (paralysis agitans), post-encephalitic parkinsonism, or symptomatic parkinsonism following CNS injury due to carbon monoxide or manganese intoxication

Side Effects

  • no Side Effects

Carbidopa has not been shown to have any overt pharmacodynamic actions in the recommended doses. No adverse reactions are associated with carbidopa; the adverse reactions reported are those related to combination therapy with levodopa or carbidopa-levodopa combination products.

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • breast-feeding
  • children
  • infants
  • neonates
  • pregnancy

Interactions

  • Asenapine
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brentuximab vedotin
  • Droxidopa
  • Iloperidone
  • Isoniazid, INH
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Isoniazid, INH; Rifampin
  • Lurasidone
  • Metronidazole
  • Molindone

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