Carbetapentane Diphenhydramine Phenylephrine

Carbetapentane Diphenhydramine Phenylephrine Brand Names

D-Tann CD | D-Tann CT | Dytan-CD | Dytan-CS | Uni-Tann CS

What is Carbetapentane Diphenhydramine Phenylephrine

NOTE: These products have been discontinued in the U.S.

Carbetapentane diphenhydramine phenylephrine are used together for the relief of cough, nasal congestion, and rhinorrhea associated with the common cold, sinusitis, allergic rhinitis, or other upper respiratory tract conditions.

Carbetapentane is a non-opioid, centrally acting cough suppressant.

The cough suppressant effect of carbetapentane is less potent than opiates; however, unlike opiates, carbetapentane has not been associated with substance abuse.

Diphenhydramine is a first generation H1-antagonist of the ethanolamine class commonly used for treating symptoms related to histamine release such as rhinorrhea.

Ethanolamine H1-antagonists have significant antimuscarinic activity and produce marked sedation in most patients. In general, gastrointestinal side effects are minimal.

Phenylephrine is a sympathomimetic amine used as a decongestant to decrease nasal and sinus congestion.

Phenylephrine appears to have a lower propensity to cause hypertension and potential sequelae (e.g., stroke, hypertensive crisis, intracranial bleeding) than ephedrine or phenylpropanolamine.

Carbetapentane diphenhydramine phenylephrine is available by prescription in solid and liquid preparations for adults and children.

Indications

  1. allergic rhinitis
  2. common cold
  3. cough
  4. nasal congestion
  5. rhinorrhea
  6. sinusitis

Side Effects

  1. agranulocytosis
  2. anaphylactic shock
  3. angina
  4. anorexia
  5. apnea
  6. arrhythmia exacerbation
  7. ataxia
  8. blurred vision
  9. bronchial secretions
  10. chills
  11. constipation
  12. diarrhea
  13. diplopia
  14. dizziness
  15. drowsiness
  16. dyspepsia
  17. dysuria
  18. euphoria
  19. excitability
  20. fatigue
  21. hallucinations
  22. headache
  23. hemolytic anemia
  24. hyperhidrosis
  25. hypertension
  26. hypertensive crisis
  27. hypotension
  28. hypotonia
  29. insomnia
  30. irritability
  31. leukopenia
  32. mydriasis
  33. myocardial infarction
  34. nausea
  35. neuritis
  36. pallor
  37. palpitations
  38. paresthesias
  39. photophobia
  40. photosensitivity
  41. polyuria
  42. premature ventricular contractions (PVCs)
  43. psychosis
  44. rash
  45. respiratory depression
  46. restlessness
  47. seizures
  48. sinus tachycardia
  49. stroke
  50. supraventricular tachycardia (SVT)
  51. thrombocytopenia
  52. tinnitus
  53. tremor
  54. urinary retention
  55. urticaria
  56. vertigo
  57. visual impairment
  58. vomiting
  59. wheezing
  60. xerophthalmia
  61. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • acute myocardial infarction
  • aneurysm
  • angina
  • anticholinergic medications
  • arteriosclerosis
  • asthma
  • atrial fibrillation
  • atrial flutter
  • AV block
  • bladder obstruction
  • bradycardia
  • breast-feeding
  • bronchitis
  • bundle-branch block
  • cardiac arrhythmias
  • cardiac disease
  • cardiomyopathy
  • cerebrovascular disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • constipation
  • contact lenses
  • coronary artery disease
  • diabetes mellitus
  • driving or operating machinery
  • emphysema
  • ethanol ingestion
  • geriatric
  • GI disease
  • GI obstruction
  • heart failure
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • ileus
  • increased intraocular pressure
  • infants
  • intracranial bleeding
  • labor
  • MAOI therapy
  • myocardial infarction
  • neonates
  • obstetric delivery
  • organic brain syndrome
  • peptic ulcer disease
  • peripheral vascular disease
  • phenylketonuria
  • pregnancy
  • prostatic hypertrophy
  • pulmonary disease
  • pyloric stenosis
  • renal disease
  • renal failure
  • renal impairment
  • seizure disorder
  • seizures
  • status asthmaticus
  • stroke
  • tachycardia
  • thyrotoxicosis
  • tobacco smoking
  • ulcerative colitis
  • urinary retention
  • ventricular fibrillation
  • ventricular tachycardia

Interactions

  • Acarbose
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Aclidinium; Formoterol
  • Acrivastine; Pseudoephedrine
  • Albiglutide
  • Albuterol
  • Albuterol; Ipratropium
  • Aldesleukin, IL-2
  • Alfentanil
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Alogliptin; Metformin
  • Alogliptin; Pioglitazone
  • Alosetron
  • Alpha-blockers
  • Alpha-glucosidase Inhibitors
  • Alprazolam
  • Amantadine
  • Ambenonium Chloride
  • Ambrisentan
  • Amikacin
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminoglycosides
  • Amiodarone
  • Amitriptyline; Chlordiazepoxide
  • Amlodipine
  • Amlodipine; Atorvastatin
  • Amlodipine; Benazepril
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Angiotensin II receptor antagonists
  • Angiotensin-converting enzyme inhibitors
  • Anticholinergics
  • Anxiolytics; Sedatives; and Hypnotics
  • Apomorphine
  • Apraclonidine
  • Aprepitant, Fosaprepitant
  • Arformoterol
  • Artemether; Lumefantrine
  • Articaine; Epinephrine
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir; Cobicistat
  • Atenolol
  • Atenolol; Chlorthalidone
  • Atomoxetine
  • Atropine
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Atropine; Edrophonium
  • Atropine; Hyoscyamine; Phenobarbital; Scopolamine
  • atypical antipsychotic
  • Avanafil
  • Azelastine
  • Azelastine; Fluticasone
  • Azilsartan; Chlorthalidone
  • Baclofen
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  • Belladonna; Opium
  • Benazepril; Hydrochlorothiazide, HCTZ
  • Bendroflumethiazide; Nadolol
  • Benzhydrocodone; Acetaminophen
  • Benzodiazepines
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzphetamine
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  • Bisoprolol
  • Bisoprolol; Hydrochlorothiazide, HCTZ
  • Bosentan
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  • Brimonidine; Timolol
  • Bromocriptine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Brompheniramine; Pseudoephedrine
  • Budesonide
  • Budesonide; Formoterol
  • Bumetanide
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butabarbital
  • Butorphanol
  • Butyrophenone
  • Caffeine
  • Caffeine; Ergotamine
  • Calcium-channel blockers
  • Canagliflozin
  • Canagliflozin; Metformin
  • Candesartan; Hydrochlorothiazide, HCTZ
  • Cannabidiol
  • Capecitabine
  • Capsaicin; Metaxalone
  • Captopril; Hydrochlorothiazide, HCTZ
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Dextromethorphan; Pseudoephedrine
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carbinoxamine; Pseudoephedrine
  • Cardiac glycosides
  • Cariprazine
  • Carisoprodol
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
  • Chlordiazepoxide
  • Chlordiazepoxide; Clidinium
  • Chlorothiazide
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Pseudoephedrine
  • Chlorpromazine
  • Chlorthalidone
  • Chlorthalidone; Clonidine
  • Chlorzoxazone
  • Ciclesonide
  • Clevidipine
  • Clobazam
  • Clonazepam
  • Clonidine
  • Clorazepate
  • Clozapine
  • Cobicistat
  • Cocaine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Colchicine
  • Colchicine; Probenecid
  • COMT inhibitors
  • Corticosteroids
  • Cortisone
  • Cyclobenzaprine
  • Dantrolene
  • Dapagliflozin
  • Dapagliflozin; Metformin
  • Dapagliflozin; Saxagliptin
  • Daratumumab; Hyaluronidase
  • Darunavir; Cobicistat
  • Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
  • Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
  • Deflazacort
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Desmopressin
  • Deutetrabenazine
  • Dexamethasone
  • Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Dexmedetomidine
  • Dexmethylphenidate
  • Dextroamphetamine
  • Dextromethorphan; Guaifenesin; Pseudoephedrine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Diazepam
  • Dicyclomine
  • Diethylpropion
  • Digitoxin
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Dipeptidyl Peptidase-4 Inhibitors
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dorzolamide; Timolol
  • Doxazosin
  • Doxercalciferol
  • Doxorubicin
  • Dronabinol
  • Dronedarone
  • Droperidol
  • Dulaglutide
  • Dutasteride; Tamsulosin
  • Dyphylline
  • Dyphylline; Guaifenesin
  • Elexacaftor; tezacaftor; ivacaftor
  • Eliglustat
  • Elvitegravir
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enalapril; Felodipine
  • Enalapril; Hydrochlorothiazide, HCTZ
  • Enflurane
  • Entacapone
  • Epinephrine
  • Epoprostenol
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergoloid Mesylates
  • Ergonovine
  • Ergot alkaloids
  • Ergotamine
  • Ertugliflozin
  • Ertugliflozin; Metformin
  • Ertugliflozin; Sitagliptin
  • Esketamine
  • Esmolol
  • Estazolam
  • Eszopiclone
  • Ethacrynic Acid
  • Ethanol
  • Etomidate
  • Exenatide
  • Ezogabine
  • Felodipine
  • Fenofibric Acid
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Flavoxate
  • Flibanserin
  • Fludrocortisone
  • Flunisolide
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Flurazepam
  • Fluticasone
  • Fluticasone; Salmeterol
  • Fluticasone; Umeclidinium; Vilanterol
  • Fluticasone; Vilanterol
  • Formoterol
  • Formoterol; Mometasone
  • Fosinopril; Hydrochlorothiazide, HCTZ
  • Fospropofol
  • Furosemide
  • Gabapentin
  • Galantamine
  • General anesthetics
  • Gentamicin
  • Ginger, Zingiber officinale
  • Glimepiride; Pioglitazone
  • Glimepiride; Rosiglitazone
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Glycopyrrolate
  • Glycopyrrolate; Formoterol
  • Green Tea
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Pseudoephedrine
  • Guanabenz
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Heparin
  • Heterocyclic antidepressants
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydralazine; Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Lisinopril
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Moexipril
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Quinapril
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydrocortisone
  • Hydromorphone
  • Hyoscyamine
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
  • Iloperidone
  • Iloprost
  • Incretin Mimetics
  • Indacaterol
  • Indacaterol; Glycopyrrolate
  • Indapamide
  • Insulin Degludec; Liraglutide
  • Insulin Glargine; Lixisenatide
  • Insulins
  • Iobenguane I 131
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  • Kanamycin
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  • Labetalol
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  • Levobetaxolol
  • Levobunolol
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Levothyroxine
  • Levothyroxine; Liothyronine (Porcine)
  • Levothyroxine; Liothyronine (Synthetic)
  • Linagliptin; Metformin
  • Linezolid
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  • Liraglutide
  • Lithium
  • Lixisenatide
  • Lofexidine
  • Loop diuretics
  • Lopinavir; Ritonavir
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Lorazepam
  • Loxapine
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  • Lumateperone
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  • Metformin; Saxagliptin
  • Metformin; Sitagliptin
  • Methadone
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  • Methenamine; Sodium Acid Phosphate; Methylene Blue; Hyoscyamine
  • Methocarbamol
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  • Vigabatrin
  • Vilazodone
  • Yohimbine
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  • Ziprasidone
  • Zolpidem
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