Amlodipine and Atorvastatin Brand Name– Caduet
What is Amlodipine and Atorvastatin
Amlodipine and atorvastatin (CADUET) is a combination product which may be substituted for its individually titrated components.
Amlodipine, a calcium-channel blocker and potent vasodilator, is used for the treatment of hypertension, chronic stable angina pectoris, and/or Prinzmetal’s variant angina.
Amlodipine has the longest half-life of the calcium-channel blocker group, thus allowing for once-daily dosing. Atorvastatin is an HMG-CoA reductase inhibitor which is primarily used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia.
Atorvastatin may also be used in the treatment of homozygous familial hypercholesterolemia.
CADUET was approved by the FDA on January 30, 2004.
Indications
- angina
- hypercholesterolemia
- hyperlipoproteinemia
- hypertension
- hypertriglyceridemia
- myocardial infarction prophylaxis
- stroke prophylaxis
- variant angina
NOTE: Patients receiving amlodipine; atorvastatin therapy should also be placed on a standard cholesterol-lowering diet, and this diet should be continued throughout therapy. Serum lipoprotein concentrations should be determined periodically and dosage adjusted according to individual response and established NCEP treatment guidelines.
Side Effects
- abdominal pain
- amnesia
- anaphylactoid reactions
- angina
- angioedema
- anorexia
- arrhythmia exacerbation
- arthralgia
- atrial fibrillation
- back pain
- bradycardia
- bullous rash
- chest pain (unspecified)
- cholestasis
- cirrhosis
- Co-Enzyme Q-10 deficiency
- confusion
- constipation
- diabetes mellitus
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dysarthria
- dyspepsia
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- erythema multiforme
- fatigue
- fever
- flatulence
- flushing
- gingival hyperplasia
- gynecomastia
- headache
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperglycemia
- hypoesthesia
- hypotension
- immune-mediated necrotizing myopathy
- interstitial lung disease
- jaundice
- leukopenia
- maculopapular rash
- malaise
- memory impairment
- muscle paralysis
- myalgia
- myasthenia
- myoglobinuria
- myopathy
- nausea
- orthostatic hypotension
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- peripheral neuropathy
- peripheral vasodilation
- pharyngitis
- pruritus
- purpura
- rash
- renal failure (unspecified)
- rhabdomyolysis
- sinus tachycardia
- Stevens-Johnson syndrome
- stroke
- syncope
- thrombocytopenia
- toxic epidermal necrolysis
- tremor
- urticaria
- vasculitis
- ventricular tachycardia
- vertigo
- vomiting
- weakness
Monitoring Parameters
- blood pressure
- creatine phosphokinase (CPK)
- heart rate
- LFTs
- serum cholesterol profile
Contraindications
- acute myocardial infarction
- alcoholism
- aortic stenosis
- bradycardia
- breast-feeding
- cardiogenic shock
- children
- cholestasis
- contraception requirements
- coronary artery disease
- diabetes mellitus
- dihydropyridine hypersensitivity
- electrolyte imbalance
- endocrine disease
- geriatric
- heart failure
- hepatic disease
- hepatic encephalopathy
- hepatitis
- hypertension
- infants
- infection
- jaundice
- myopathy
- neonates
- organ transplant
- pregnancy
- renal disease
- renal failure
- renal impairment
- reproductive risk
- rhabdomyolysis
- seizure disorder
- stroke
- surgery
- trauma
- ventricular dysfunction
Interactions
- Acebutolol
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Pioglitazone
- Alprostadil
- Aluminum Hydroxide
- Aluminum Hydroxide; Magnesium Carbonate
- Aluminum Hydroxide; Magnesium Hydroxide
- Aluminum Hydroxide; Magnesium Hydroxide; Simethicone
- Aluminum Hydroxide; Magnesium Trisilicate
- Amifostine
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Celecoxib
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Antacids
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
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- Bosentan
- Brigatinib
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bupivacaine; Lidocaine
- Butabarbital
- Cabergoline
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- Calcium Carbonate
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- Capmatinib
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- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Cimetidine
- Ciprofloxacin
- Cisapride
- Clarithromycin
- Clobazam
- Clopidogrel
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
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- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
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- Colestipol
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- Conjugated Estrogens; Bazedoxifene
- Crizotinib
- Cyclosporine
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- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
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- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexamethasone
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- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dofetilide
- Dorzolamide; Timolol
- Dronabinol
- Dronedarone
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Eltrombopag
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Ergonovine
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esmolol
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
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- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenofibrate
- Fenofibric Acid
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- Fospropofol
- Gemfibrozil
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- Glecaprevir; Pibrentasvir
- Glimepiride; Pioglitazone
- grapefruit juice
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Indinavir
- Indomethacin
- Intravenous Lipid Emulsions
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Istradefylline
- Itraconazole
- Ixabepilone
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lasmiditan
- Ledipasvir; Sofosbuvir
- Lefamulin
- Leflunomide
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levodopa
- Lidocaine
- Lidocaine; Prilocaine
- Lisdexamfetamine
- Lithium
- Lomitapide
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Magnesium Hydroxide
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Melatonin
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Metformin; Pioglitazone
- Methadone
- Methamphetamine
- Methohexital
- Methoxsalen
- Methylergonovine
- Methylphenidate
- Methysergide
- Metoprolol
- Mifepristone
- Milrinone
- Mitotane
- Modafinil
- Nabumetone
- Nadolol
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nicardipine
- Nilotinib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Ombitasvir; Paritaprevir; Ritonavir
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Omeprazole; Sodium Bicarbonate
- Oritavancin
- Oxaprozin
- Oxcarbazepine
- Oxycodone
- Oxymetazoline
- Paliperidone
- Pasireotide
- Pazopanib
- Penbutolol
- Pentobarbital
- Pentoxifylline
- Perampanel
- Pexidartinib
- Phenelzine
- Phenobarbital
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Pioglitazone
- Piroxicam
- Posaconazole
- Prazosin
- Primidone
- Procainamide
- Procaine
- Propofol
- Propoxyphene
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinidine
- Quinine
- Raltegravir
- Ranolazine
- Rasagiline
- Red Yeast Rice
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
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- Riluzole
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Sapropterin
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- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
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- Sincalide
- Sirolimus
- Sodium Bicarbonate
- Sofosbuvir; Velpatasvir
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- Sorafenib
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