Amlodipine and Benazepril

Amlodipine and Benazepril Brand Name– Lotrel

What is Amlodipine and Benazepril

Amlodipine and Benazepril are used together in an oral preparation to treat hypertension.

Amlodipine is a dihydropyridine calcium channel blocker and is a potent peripheral vasodilator, similar to nifedipine and other members of the dihydropyridine class, although amlodipine has the longest half-life of the group, thus allowing for once-daily dosing.

Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. Benazepril is a prodrug that is hydrolyzed by esterases to the active metabolite benazeprilat, whose long duration of action makes benazepril suitable for once-daily dosing.

Benazepril and benazeprilat lack a sulfhydryl group, which has implications for the safety profile.

Benazepril monotherapy is less effective in black hypertensive patients (a low-renin hypertensive population), and the antihypertensive effects of the combination product are primarily attributed to the amlodipine component in this population.

Compared to the same doses of benazepril and amlodipine monotherapy, Lotrel® regimens are associated with less edema and greater antihypertensive effects.

Amlodipine and benazepril (Lotrel) was approved for hypertension in 1995.

Indications

  • hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

  1. abdominal pain
  2. alopecia
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. anxiety
  7. asthenia
  8. azotemia
  9. back pain
  10. chest pain (unspecified)
  11. cholestasis
  12. constipation
  13. cough
  14. diarrhea
  15. dizziness
  16. drowsiness
  17. dyspepsia
  18. edema
  19. elevated hepatic enzymes
  20. eosinophilic pneumonia
  21. esophagitis
  22. fatigue
  23. flushing
  24. gingival hyperplasia
  25. gout
  26. gynecomastia
  27. headache
  28. hemolytic anemia
  29. hepatic failure
  30. hepatic necrosis
  31. hot flashes
  32. hyperbilirubinemia
  33. hyperkalemia
  34. hyperuricemia
  35. hypokalemia
  36. hypotension
  37. impotence (erectile dysfunction)
  38. insomnia
  39. jaundice
  40. laryngeal edema
  41. libido decrease
  42. muscle cramps
  43. musculoskeletal pain
  44. myocardial infarction
  45. nausea
  46. neuritis
  47. neutropenia
  48. oliguria
  49. palpitations
  50. pancreatitis
  51. pemphigus
  52. peripheral edema
  53. peripheral vasodilation
  54. pharyngitis
  55. polyuria
  56. rash
  57. renal failure (unspecified)
  58. sinus tachycardia
  59. Stevens-Johnson syndrome
  60. teratogenesis
  61. thrombocytopenia
  62. tinnitus
  63. tremor
  64. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • serum creatinine/BUN
  • serum potassium
  • serum sodium

Contraindications

  • ACE-inhibitor induced angioedema
  • acute myocardial infarction
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
  • aortic stenosis
  • autoimmune disease
  • Black patients
  • bone marrow suppression
  • bradycardia
  • breast-feeding
  • cardiogenic shock
  • cardiomyopathy
  • cerebrovascular disease
  • collagen-vascular disease
  • coronary artery disease
  • dialysis
  • dihydropyridine hypersensitivity
  • geriatric
  • heart failure
  • hepatic disease
  • history of angioedema
  • hymenoptera venom (insect sting) allergy desensitization
  • hyperkalemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • immunosuppression
  • low-density lipoprotein apheresis
  • pregnancy
  • renal artery stenosis
  • renal disease
  • renal failure
  • renal impairment
  • scleroderma
  • surgery
  • systemic lupus erythematosus (SLE)
  • ventricular dysfunction

Interactions

  • Acebutolol
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Acrivastine; Pseudoephedrine
  • Aldesleukin, IL-2
  • Alemtuzumab
  • Alfentanil
  • Aliskiren
  • Aliskiren; Amlodipine
  • Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
  • Aliskiren; Hydrochlorothiazide, HCTZ
  • Aliskiren; Valsartan
  • Alogliptin; Metformin
  • Alpha-glucosidase Inhibitors
  • Alprostadil
  • Amifostine
  • Amiloride
  • Amiloride; Hydrochlorothiazide, HCTZ
  • Aminolevulinic Acid
  • Amiodarone
  • Amlodipine; Celecoxib
  • Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
  • Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
  • Amlodipine; Olmesartan
  • Amlodipine; Telmisartan
  • Amlodipine; Valsartan
  • Amobarbital
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Amphetamine; Dextroamphetamine Salts
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  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atazanavir
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  • Brompheniramine; Carbetapentane; Phenylephrine
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  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Phenylephrine
  • Chlorpheniramine; Pseudoephedrine
  • Ciprofloxacin
  • Cisapride
  • Clarithromycin
  • Clobazam
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  • Co-Enzyme Q10, Ubiquinone
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  • Dextromethorphan; Quinidine
  • Diazoxide
  • Diclofenac
  • Diclofenac; Misoprostol
  • Diethylpropion
  • Diflunisal
  • Digoxin
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Dihydroergotamine
  • Diltiazem
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Diphenhydramine; Ibuprofen
  • Diphenhydramine; Naproxen
  • Diphenhydramine; Phenylephrine
  • Dofetilide
  • Dorzolamide; Timolol
  • Dronabinol
  • Dronedarone
  • Drospirenone
  • Drospirenone; Estradiol
  • Drospirenone; Ethinyl Estradiol
  • Drospirenone; Ethinyl Estradiol; Levomefolate
  • Duloxetine
  • Dutasteride; Tamsulosin
  • Duvelisib
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Elagolix
  • Elagolix; Estradiol; Norethindrone acetate
  • Elbasvir; Grazoprevir
  • Eliglustat
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
  • Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
  • Empagliflozin
  • Empagliflozin; Linagliptin
  • Empagliflozin; Linagliptin; Metformin
  • Empagliflozin; Metformin
  • Enflurane
  • Entecavir
  • Enzalutamide
  • Ephedrine
  • Epirubicin
  • Eplerenone
  • Epoprostenol
  • Eprosartan
  • Eprosartan; Hydrochlorothiazide, HCTZ
  • Ergonovine
  • Ergotamine
  • Ertugliflozin; Metformin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Eslicarbazepine
  • Esmolol
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  • Estradiol
  • Estradiol Cypionate; Medroxyprogesterone
  • Ethinyl Estradiol
  • Ethinyl Estradiol; Desogestrel
  • Ethinyl Estradiol; Ethynodiol Diacetate
  • Ethinyl Estradiol; Etonogestrel
  • Ethinyl Estradiol; Levonorgestrel
  • Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
  • Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
  • Ethinyl Estradiol; Norelgestromin
  • Ethinyl Estradiol; Norethindrone
  • Ethinyl Estradiol; Norethindrone Acetate
  • Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
  • Ethinyl Estradiol; Norethindrone; Ferrous fumarate
  • Ethinyl Estradiol; Norgestimate
  • Ethinyl Estradiol; Norgestrel
  • Ethosuximide
  • Ethotoin
  • Etodolac
  • Etomidate
  • Etravirine
  • Everolimus
  • Ezetimibe; Simvastatin
  • Famotidine; Ibuprofen
  • Fedratinib
  • Fenoprofen
  • Fentanyl
  • Fexofenadine; Pseudoephedrine
  • Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
  • Fluconazole
  • Fluorescein
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Flurbiprofen
  • Flutamide
  • Fluvoxamine
  • Fosamprenavir
  • Fosphenytoin
  • Fospropofol
  • General anesthetics
  • Ginkgo, Ginkgo biloba
  • Ginseng, Panax ginseng
  • Glipizide; Metformin
  • Glyburide; Metformin
  • Gold
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Guaifenesin; Phenylephrine
  • Guaifenesin; Pseudoephedrine
  • Haloperidol
  • Halothane
  • Heparin
  • Homatropine; Hydrocodone
  • Hydantoins
  • Hydralazine; Isosorbide Dinitrate, ISDN
  • Hydrochlorothiazide, HCTZ; Irbesartan
  • Hydrochlorothiazide, HCTZ; Losartan
  • Hydrochlorothiazide, HCTZ; Metoprolol
  • Hydrochlorothiazide, HCTZ; Olmesartan
  • Hydrochlorothiazide, HCTZ; Propranolol
  • Hydrochlorothiazide, HCTZ; Spironolactone
  • Hydrochlorothiazide, HCTZ; Telmisartan
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydrochlorothiazide, HCTZ; Valsartan
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Ibuprofen
  • Ibuprofen; Oxycodone
  • Ibuprofen; Pseudoephedrine
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  • Isosulfan Blue
  • Itraconazole
  • Kanamycin
  • Ketamine
  • Ketoconazole
  • Ketoprofen
  • Ketorolac
  • Labetalol
  • Lacosamide
  • Lanreotide
  • Lansoprazole; Naproxen
  • Lanthanum Carbonate
  • Lasmiditan
  • Lefamulin
  • Lesinurad
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  • Letermovir
  • Levobetaxolol
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  • Levodopa
  • Lidocaine
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  • Linagliptin; Metformin
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  • Loperamide
  • Loperamide; Simethicone
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  • Loratadine; Pseudoephedrine
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  • Losartan
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  • Lovastatin; Niacin
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  • Lurasidone
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  • Metformin
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  • Naproxen
  • Naproxen; Pseudoephedrine
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  • Verapamil
  • Verteporfin
  • Vinorelbine
  • Voriconazole
  • Yohimbine
  • Zafirlukast
  • Ziprasidone
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