Aliskiren and Amlodipine Brand Name– Tekamlo
What is Aliskiren and Amlodipine
Aliskiren and amlodipine is a combination product for the treatment of hypertension.
Aliskiren is a direct renin inhibitor; amlodipine is a calcium-channel blocker and a potent peripheral vasodilator.
The combination of a calcium-channel blocker with a renin inhibitor produces complimentary effects on the renin system, sympathetic activity, and vascular endothelial function.
Additionally, calcium-channel blockers produce a direct relaxant effect on vascular smooth muscle, which augments the blood pressure lowering effect of direct renin inhibitors.
Indications
- hypertension
For the treatment of hypertension, either alone or in combination with other antihypertensive agents
Side Effects
- abdominal pain
- anemia
- angioedema
- anorexia
- anxiety
- arrhythmia exacerbation
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bradycardia
- chest pain (unspecified)
- cholestasis
- conjunctivitis
- constipation
- cough
- depression
- diaphoresis
- diarrhea
- diplopia
- dyspepsia
- dysphagia
- dyspnea
- elevated hepatic enzymes
- epistaxis
- erythema
- erythema multiforme
- flatulence
- flushing
- gastroesophageal reflux
- gingival hyperplasia
- gout
- gynecomastia
- hepatitis
- hyperglycemia
- hyperkalemia
- hyperuricemia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- leukopenia
- libido decrease
- maculopapular rash
- malaise
- muscle cramps
- myalgia
- nephrolithiasis
- nightmares
- nocturia
- ocular pain
- orthostatic hypotension
- pancreatitis
- paresthesias
- peripheral edema
- peripheral neuropathy
- pruritus
- purpura
- rash
- renal failure (unspecified)
- seizures
- syncope
- teratogenesis
- thrombocytopenia
- tinnitus
- tremor
- vasculitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
- serum potassium
Contraindications
- ACE-inhibitor induced angioedema
- angina
- angioedema
- aortic stenosis
- biliary cirrhosis
- Black patients
- breast-feeding
- children
- coronary artery disease
- diabetes mellitus
- gastroesophageal reflux disease (GERD)
- geriatric
- heart failure
- hepatic disease
- hereditary angioedema
- hiatal hernia
- hyperkalemia
- hypokalemia
- hyponatremia
- hypotension
- hypovolemia
- infants
- myocardial infarction
- neonates
- pregnancy
- renal artery stenosis
- renal failure
- renal impairment
- surgery
Interactions
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Propoxyphene
- Acetaminophen; Pseudoephedrine
- Acetaminophen; Tramadol
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Aliskiren; Valsartan
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Angiotensin II receptor antagonists
- Angiotensin-converting enzyme inhibitors
- Apalutamide
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aripiprazole
- Armodafinil
- Asenapine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Oxycodone
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atorvastatin
- Atorvastatin; Ezetimibe
- Avanafil
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Barbiturates
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Benazepril
- Benazepril; Hydrochlorothiazide, HCTZ
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Benzphetamine
- Beta-blockers
- Betaxolol
- Bexarotene
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Brimonidine; Timolol
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Bumetanide
- Bupivacaine; Lidocaine
- Cabergoline
- Caffeine; Ergotamine
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Captopril
- Captopril; Hydrochlorothiazide, HCTZ
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Cenobamate
- Ceritinib
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloramphenicol
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Ciprofloxacin
- Cisapride
- Citric Acid; Potassium Citrate
- Citric Acid; Potassium Citrate; Sodium Citrate
- Clarithromycin
- Clobazam
- Clopidogrel
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Daclatasvir
- Danazol
- Dantrolene
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexamethasone
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Potassium Guaiacolsulfonate
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Diethylpropion
- Diflunisal
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diltiazem
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Dofetilide
- Dorzolamide; Timolol
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elbasvir; Grazoprevir
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enalapril, Enalaprilat
- Enalapril; Felodipine
- Enalapril; Hydrochlorothiazide, HCTZ
- Enflurane
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergonovine
- Ergotamine
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Esmolol
- Esomeprazole; Naproxen
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Ethacrynic Acid
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Ethotoin
- Etodolac
- Etomidate
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenoldopam
- Fenoprofen
- Fentanyl
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluconazole
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurbiprofen
- Flutamide
- Fluvoxamine
- Fosamprenavir
- Fosinopril
- Fosinopril; Hydrochlorothiazide, HCTZ
- Fosphenytoin
- Fospropofol
- Fostamatinib
- Furosemide
- General anesthetics
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- Glecaprevir; Pibrentasvir
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Potassium Guaiacolsulfonate
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Hetastarch; Dextrose; Electrolytes
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine
- Hydralazine; Hydrochlorothiazide, HCTZ
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Lisinopril
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Moexipril
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Quinapril
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibritumomab Tiuxetan
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Idelalisib
- Iloperidone
- Iloprost
- Imatinib
- Indapamide
- Indinavir
- Indomethacin
- Intravenous Lipid Emulsions
- Iodine; Potassium Iodide, KI
- Irbesartan
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Itraconazole
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lanreotide
- Lansoprazole; Naproxen
- Lasmiditan
- Lefamulin
- Lesinurad
- Lesinurad; Allopurinol
- Letermovir
- Levobetaxolol
- Levobunolol
- Levodopa
- Lidocaine
- Lisdexamfetamine
- Lisinopril
- Lithium
- Lomitapide
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Lorlatinib
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lurasidone
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Meloxicam
- Mepivacaine
- Mepivacaine; Levonordefrin
- Mestranol; Norethindrone
- Methadone
- Methamphetamine
- Methoxsalen
- Methylergonovine
- Methylphenidate
- Methysergide
- Metoprolol
- Mifepristone
- Milrinone
- Minoxidil
- Mitotane
- Modafinil
- Moexipril
- Nabumetone
- Nadolol
- Nafcillin
- Naproxen
- Naproxen; Pseudoephedrine
- Naproxen; Sumatriptan
- Nebivolol
- Nebivolol; Valsartan
- Nefazodone
- Nelfinavir
- Nesiritide, BNP
- Netupitant, Fosnetupitant; Palonosetron
- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nilotinib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Olmesartan
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Oxaprozin
- Oxcarbazepine
- Oxycodone
- Oxymetazoline
- Paliperidone
- Pasireotide
- Pazopanib
- Penbutolol
- Pentoxifylline
- Perampanel
- Perindopril
- Perindopril; Amlodipine
- Phenelzine
- Phentermine; Topiramate
- Phenylephrine
- Phenylephrine; Promethazine
- Phenytoin
- Photosensitizing agents (topical)
- Pindolol
- Piroxicam
- Ponatinib
- Posaconazole
- Potassium
- Potassium Acetate
- Potassium Bicarbonate
- Potassium Chloride
- Potassium Citrate
- Potassium Gluconate
- Potassium Iodide, KI
- Potassium-sparing diuretics
- Prazosin
- Procainamide
- Procaine
- Propofol
- Propoxyphene
- Propranolol
- Protease inhibitors
- Pseudoephedrine
- Quinapril
- Quinidine
- Quinine
- Ramipril
- Rasagiline
- Remifentanil
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Risperidone
- Ritonavir
- Rofecoxib
- Sacubitril; Valsartan
- Sapropterin
- Saquinavir
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Sevoflurane
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sincalide
- Sirolimus
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
- Sulindac
- Tacrolimus
- Tamsulosin
- Telaprevir
- Telithromycin
- Telmisartan
- Telotristat Ethyl
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thalidomide
- Thiothixene
- Timolol
- Tipranavir
- Tizanidine
- Tolmetin
- Topiramate
- Torsemide
- Tramadol
- Trandolapril
- Trandolapril; Verapamil
- Tranylcypromine
- Trazodone
- Treprostinil
- Triamterene
- Valdecoxib
- Valproic Acid, Divalproex Sodium
- Valsartan
- Vasodilators
- Vemurafenib
- Verapamil
- Verteporfin
- Vinorelbine
- Voriconazole
- Warfarin
- Yohimbine
- Zafirlukast
- Ziprasidone
- Zonisamide