Amlodipine Brand Name– Katerzia | Norvasc
What is Amlodipine
Amlodipine is an oral calcium-channel blocker. It is used for the treatment of hypertension, chronic stable angina pectoris, and Prinzmetal’s variant angina.
Amlodipine is considered less effective than ACE inhibitors or AII-receptor antagonists in slowing the progression of renal disease in patients with diabetic nephropathy or hypertensive renal disease.
Amlodipine is a potent peripheral vasodilator, similar to nifedipine and other members of the dihydropyridine class, although amlodipine has the longest half-life of the group, thus allowing for once-daily dosing.
The CAMELOT trial demonstrated that amlodipine use in patients with documented coronary artery disease CAD results in reduced coronary revascularization procedures and reduced hospitalizations due to angina.
Indications
- angina
- coronary artery disease
- hypertension
- variant angina
Side Effects
- abdominal pain
- angina
- angioedema
- anorexia
- anxiety
- arrhythmia exacerbation
- arthralgia
- asthenia
- atrial fibrillation
- back pain
- bradycardia
- chest pain (unspecified)
- chills
- conjunctivitis
- constipation
- depression
- diaphoresis
- diarrhea
- diplopia
- dizziness
- drowsiness
- dysphagia
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- erythema
- erythema multiforme
- fatigue
- flatulence
- flushing
- gingival hyperplasia
- gynecomastia
- hepatitis
- hot flashes
- hyperglycemia
- hypoesthesia
- hypotension
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- leukopenia
- libido decrease
- maculopapular rash
- malaise
- muscle cramps
- myalgia
- myocardial infarction
- nausea
- nightmares
- nocturia
- ocular pain
- orthostatic hypotension
- palpitations
- pancreatitis
- paresthesias
- peripheral edema
- peripheral neuropathy
- polydipsia
- pruritus
- purpura
- rash
- sinus tachycardia
- syncope
- thrombocytopenia
- tinnitus
- tremor
- vasculitis
- ventricular tachycardia
- vertigo
- visual impairment
- vomiting
- weight gain
- weight loss
- xerostomia
Monitoring Parameters
- blood pressure
Contraindications
- acute myocardial infarction
- aortic stenosis
- breast-feeding
- coronary artery disease
- geriatric
- hepatic disease
- pregnancy
Interactions
- Acebutolol
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
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