Zanamivir

What is Zanamivir

Zanamivir is a neuraminidase inhibitor antiviral agent that is most commonly administered via oral inhalation and indicated for the treatment of uncomplicated influenza A and B infection in patients 7 years and older and for seasonal influenza prophylaxis in patients 5 years and older.

Brand Name

Relenza

Indications & Dosage

  • avian influenza A (H5N1) virus
  • avian influenza A (H7N9) virus
  • avian influenza A virus infection
  • avian influenza prophylaxis
  • influenza A virus
  • influenza A virus infection
  • influenza B virus
  • influenza B virus infection
  • seasonal influenza prophylaxis

Side Effects

  1. abdominal pain
  2. agitation
  3. anaphylactoid reactions
  4. angioedema
  5. anorexia
  6. anxiety
  7. appetite stimulation
  8. arrhythmia exacerbation
  9. arthralgia
  10. bronchospasm
  11. chills
  12. confusion
  13. cough
  14. delirium
  15. diarrhea
  16. dizziness
  17. dyspnea
  18. elevated hepatic enzymes
  19. emotional lability
  20. erythema multiforme
  21. fatigue
  22. fever
  23. hallucinations
  24. headache
  25. infection
  26. laryngeal edema
  27. lymphopenia
  28. malaise
  29. musculoskeletal pain
  30. myalgia
  31. nausea
  32. neutropenia
  33. nightmares
  34. psychosis
  35. rash
  36. seizures
  37. sinusitis
  38. Stevens-Johnson syndrome
  39. syncope
  40. toxic epidermal necrolysis
  41. urticaria
  42. vomiting

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • administration via nebulizer
  • angioedema
  • asthma
  • breast-feeding
  • bronchitis
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • emphysema
  • geriatric
  • milk protein hypersensitivity
  • pregnancy
  • pulmonary disease
  • renal failure
  • renal impairment
  • Reye’s syndrome
  • serious rash
  • vaccination
  • viral infection

Interactions

  • Intranasal Influenza Vaccine
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