Secukinumab

What is Secukinumab

Secukinumab is a subcutaneously administered human IgG1 monoclonal antibody that selectively binds to the interleukin-17A (IL-17A) cytokine, inhibiting its interaction with the IL-17A receptor.

Maintenance dosing is given once monthly. Secukinumab is useful in a variety of inflammatory disorders.

Elevated concentrations of IL-17A are found in psoriatic plaques; secukinumab is approved for moderate to severe plaque psoriasis in adults who are candidates for systemic therapy or phototherapy; clinical trials included patients naive to treatment and patients who had not responded adequately to nonbiologic therapies or other biologic treatments.

Secukinumab is also indicated for active psoriatic arthritis (PsA) and ankylosing spondylitis (AS) in adults. In adults with PsA, the drug improves clinical signs and symptoms, inhibits the radiographic progression of structural joint damage, and improves physical function.

Brand Name

Cosentyx

Indications & Dosage

  • ankylosing spondylitis
  • psoriasis
  • psoriatic arthritis

Side Effects

  • anaphylactoid reactions
  • antibody formation
  • candidiasis
  • diarrhea
  • elevated hepatic enzymes
  • infection
  • inflammatory bowel disease
  • neutropenia
  • ocular infection
  • oral ulceration
  • pharyngitis
  • rhinitis
  • rhinorrhea
  • sinusitis
  • urticaria

Monitoring Parameters

  • tuberculin skin test

Contraindications

  • breast-feeding
  • Crohn’s disease
  • infection
  • inflammatory bowel disease
  • latex hypersensitivity
  • pregnancy
  • tuberculosis
  • ulcerative colitis
  • vaccination

Interactions

  • Bacillus Calmette-Guerin Vaccine, BCG
  • Baricitinib
  • Canakinumab
  • Carbamazepine
  • Cyclosporine
  • Ethosuximide
  • Fosphenytoin
  • Influenza Virus Vaccine
  • Intranasal Influenza Vaccine
  • Live Vaccines
  • Measles Virus; Mumps Virus; Rubella Virus; Varicella Virus Vaccine, Live
  • Measles/Mumps/Rubella Vaccines, MMR
  • Phenytoin
  • Rotavirus Vaccine
  • Rubella Virus Vaccine Live
  • Sarilumab
  • Smallpox and Monkeypox Vaccine, Live, Nonreplicating
  • Smallpox Vaccine, Vaccinia Vaccine
  • Tacrolimus
  • Theophylline, Aminophylline
  • Tocilizumab
  • Tofacitinib
  • Typhoid Vaccine
  • Upadacitinib
  • Varicella-Zoster Virus Vaccine, Live
  • Warfarin
  • Yellow Fever Vaccine, Live
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