What is Zanubrutinib
Zanubrutinib is a Bruton tyrosine kinase (BTK) inhibitor approved for the treatment of adult patients with mantle cell lymphoma who have received at least 1 prior therapy.
It was granted an accelerated approval for use in these patients.
Fatal and serious bleeding events have been reported with zanubrutinib therapy, including intracranial bleeding and GI bleeding.
Brand Name
BRUKINSA
Indications & Dosage
- mantle cell lymphoma (MCL)
For the treatment of mantle cell lymphoma (MCL)
NOTE: Zanubrutinib has been designated as an orphan drug by the FDA for the treatment of MCL.
Side Effects
- anemia
- anemia
- arthralgia
- atrial fibrillation
- atrial flutter
- back pain
- bleeding
- bleeding
- constipation
- cough
- diarrhea
- diarrhea
- ecchymosis
- elevated hepatic enzymes
- elevated hepatic enzymes
- fatigue
- GI bleeding
- headache
- hematoma
- hematoma
- hematuria
- hematuria
- hepatitis
- hyperbilirubinemia
- hyperbilirubinemia
- hypertension
- hypertension
- hyperuricemia
- hypokalemia
- hypokalemia
- infection
- infection
- intracranial bleeding
- leukopenia
- leukopenia
- lymphocytosis
- lymphocytosis
- musculoskeletal pain
- musculoskeletal pain
- myalgia
- neutropenia
- neutropenia
- new primary malignancy
- petechiae
- purpura
- rash
- skin cancer
- thrombocytopenia
- thrombocytopenia
Monitoring Parameters
- CBC with differential
- ECG
- LFTs
- pregnancy testing
Contraindications
- anemia
- anticoagulant therapy
- bleeding
- breast-feeding
- cardiac arrhythmias
- contraception requirements
- dental work
- fungal infection
- GI bleeding
- hepatic disease
- hepatitis B exacerbation
- hypertension
- infection
- intracranial bleeding
- male-mediated teratogenicity
- neutropenia
- new primary malignancy
- pregnancy
- pregnancy testing
- reproductive risk
- sunlight (UV) exposure
- surgery
- thrombocytopenia
- viral infection
Interactions
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Alfentanil
- Amiodarone
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Apalutamide
- Aprepitant, Fosaprepitant
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Atazanavir
- Atazanavir; Cobicistat
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bexarotene
- Bosentan
- Butabarbital
- Carbamazepine
- Cenobamate
- Ceritinib
- Chloramphenicol
- Ciprofloxacin
- Clarithromycin
- Cobicistat
- Conivaptan
- Crizotinib
- Cyclosporine
- Dabrafenib
- Danazol
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Delavirdine
- Dexamethasone
- Diltiazem
- Dronedarone
- Duvelisib
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix
- Elagolix; Estradiol; Norethindrone acetate
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Enzalutamide
- Erythromycin
- Erythromycin; Sulfisoxazole
- Eslicarbazepine
- Etravirine
- Fedratinib
- Fluconazole
- Fluvoxamine
- Fosamprenavir
- Fosphenytoin
- grapefruit juice
- Idelalisib
- Imatinib
- Indinavir
- Isavuconazonium
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Itraconazole
- Ketoconazole
- Lefamulin
- Letermovir
- Lopinavir; Ritonavir
- Lorlatinib
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Methohexital
- Mifepristone
- Mitotane
- Modafinil
- Nafcillin
- Nefazodone
- Nelfinavir
- Netupitant, Fosnetupitant; Palonosetron
- Nevirapine
- Nilotinib
- Nisoldipine
- Ombitasvir; Paritaprevir; Ritonavir
- Omeprazole; Amoxicillin; Rifabutin
- Phenobarbital
- Phenytoin
- Posaconazole
- Primidone
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
- Ritonavir
- Saquinavir
- Secobarbital
- Sirolimus
- St. John’s Wort, Hypericum perforatum
- Tacrolimus
- Telithromycin
- Tipranavir
- Trandolapril; Verapamil
- Tucatinib
- Ubrogepant
- Verapamil
- Voriconazole
