Triprolidine

What is Triprolidine

Triprolidine is a first generation oral sedating antihistamine (H1-blocker) belonging to the alkylamine class.

It is used for the treatment of allergic and vasomotor rhinitis, allergic conjunctivitis, and uncomplicated skin manifestations of angioedema and urticaria. Triprolidine was approved by the FDA in 1958.

Indications & Dosage

  • allergic conjunctivitis
  • allergic rhinitis
  • rhinorrhea
  • sneezing

For the treatment of symptoms associated with perennial and seasonal allergic rhinitis or other respiratory allergies, including rhinorrhea, sneezing, itching of the nose or throat, or allergic conjunctivitis

Side Effects

  1. agitation
  2. anorexia
  3. anxiety
  4. arrhythmia exacerbation
  5. blurred vision
  6. confusion
  7. constipation
  8. dizziness
  9. drowsiness
  10. dyskinesia
  11. dysuria
  12. hallucinations
  13. headache
  14. impotence (erectile dysfunction)
  15. insomnia
  16. irritability
  17. lethargy
  18. mydriasis
  19. nausea
  20. orthostatic hypotension
  21. peripheral vasodilation
  22. polyuria
  23. pyrosis (heartburn)
  24. seizures
  25. sinus tachycardia
  26. skin irritation
  27. urinary retention
  28. vomiting
  29. xerophthalmia
  30. xerostomia

Monitoring Parameters

  • laboratory monitoring not necessary

Contraindications

  • anticholinergic medications
  • asthma
  • bladder obstruction
  • breast-feeding
  • bronchitis
  • cardiac disease
  • children
  • chronic obstructive pulmonary disease (COPD)
  • closed-angle glaucoma
  • contact lenses
  • driving or operating machinery
  • emphysema
  • geriatric
  • GI obstruction
  • hepatic disease
  • hypertension
  • hyperthyroidism
  • infants
  • neonates
  • peptic ulcer disease
  • phenylketonuria
  • pregnancy
  • prostatic hypertrophy

Interactions

  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Codeine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Alfentanil
  • Alosetron
  • Amantadine
  • Ambenonium Chloride
  • Amoxapine
  • Amphetamine
  • Amphetamine; Dextroamphetamine
  • Amphetamine; Dextroamphetamine Salts
  • Anticholinergics
  • Apomorphine
  • Aripiprazole
  • Asenapine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Oxycodone
  • Atropine; Difenoxin
  • Atropine; Diphenoxylate
  • Azelastine
  • Azelastine; Fluticasone
  • Baclofen
  • Barbiturates
  • Belladonna; Opium
  • Benzodiazepines
  • Benzphetamine
  • Brompheniramine; Carbetapentane; Phenylephrine
  • Brompheniramine; Guaifenesin; Hydrocodone
  • Brompheniramine; Hydrocodone; Pseudoephedrine
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Buspirone
  • Butorphanol
  • Cannabidiol
  • Capsaicin; Metaxalone
  • Carbetapentane; Chlorpheniramine
  • Carbetapentane; Chlorpheniramine; Phenylephrine
  • Carbetapentane; Diphenhydramine; Phenylephrine
  • Carbetapentane; Guaifenesin
  • Carbetapentane; Guaifenesin; Phenylephrine
  • Carbetapentane; Phenylephrine
  • Carbetapentane; Phenylephrine; Pyrilamine
  • Carbetapentane; Pseudoephedrine
  • Carbetapentane; Pyrilamine
  • Carbidopa; Levodopa; Entacapone
  • Carbinoxamine; Hydrocodone; Phenylephrine
  • Carbinoxamine; Hydrocodone; Pseudoephedrine
  • Carisoprodol
  • Cenobamate
  • Cetirizine
  • Cetirizine; Pseudoephedrine
  • Chlorpheniramine; Codeine
  • Chlorpheniramine; Dihydrocodeine; Phenylephrine
  • Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
  • Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
  • Chlorpheniramine; Hydrocodone
  • Chlorpheniramine; Hydrocodone; Phenylephrine
  • Chlorpheniramine; Hydrocodone; Pseudoephedrine
  • Chlorpromazine
  • Chlorzoxazone
  • Clobazam
  • Clozapine
  • Codeine
  • Codeine; Guaifenesin
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • COMT inhibitors
  • Cyclobenzaprine
  • Dantrolene
  • Daratumumab; Hyaluronidase
  • Desloratadine
  • Desloratadine; Pseudoephedrine
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan; Promethazine
  • Dihydrocodeine; Guaifenesin; Pseudoephedrine
  • Diphenhydramine; Hydrocodone; Phenylephrine
  • Disopyramide
  • Donepezil
  • Donepezil; Memantine
  • Dronabinol
  • Droperidol
  • Entacapone
  • Eszopiclone
  • Ethanol
  • Etomidate
  • Ezogabine
  • Fentanyl
  • Flibanserin
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fospropofol
  • Gabapentin
  • Galantamine
  • Gilteritinib
  • Guaifenesin; Hydrocodone
  • Guaifenesin; Hydrocodone; Pseudoephedrine
  • Halogenated Anesthetics
  • Haloperidol
  • Heparin
  • Homatropine; Hydrocodone
  • Hyaluronidase
  • Hyaluronidase, Recombinant; Immune Globulin
  • Hydantoins
  • Hydrocodone
  • Hydrocodone; Ibuprofen
  • Hydrocodone; Phenylephrine
  • Hydrocodone; Potassium Guaiacolsulfonate
  • Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
  • Hydrocodone; Pseudoephedrine
  • Hydromorphone
  • Ibuprofen; Oxycodone
  • Iloperidone
  • Isocarboxazid
  • Ketamine
  • Lasmiditan
  • Lemborexant
  • Levocetirizine
  • Levomethadyl
  • Levorphanol
  • Lithium
  • Loratadine
  • Loratadine; Pseudoephedrine
  • Loxapine
  • Lumateperone
  • Lurasidone
  • Magnesium Salts
  • Maprotiline
  • Meclizine
  • Melatonin
  • Meperidine
  • Meperidine; Promethazine
  • Meprobamate
  • Metaxalone
  • Methadone
  • Methamphetamine
  • Methocarbamol
  • Metoclopramide
  • Metyrapone
  • Metyrosine
  • Minocycline
  • Mirtazapine
  • Mitotane
  • Molindone
  • Monoamine oxidase inhibitors
  • Morphine
  • Morphine; Naltrexone
  • Nabilone
  • Nalbuphine
  • Nefazodone
  • Olanzapine
  • Opiate Agonists
  • Orphenadrine
  • Oxycodone
  • Oxymorphone
  • Paliperidone
  • Paroxetine
  • Pentazocine
  • Pentazocine; Naloxone
  • Perampanel
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenelzine
  • Phenylephrine; Promethazine
  • Pimozide
  • Pramipexole
  • Pregabalin
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propofol
  • Propoxyphene
  • Quetiapine
  • Ramelteon
  • Rasagiline
  • Remifentanil
  • Risperidone
  • Rituximab; Hyaluronidase
  • Rivastigmine
  • Ropinirole
  • Safinamide
  • Selegiline
  • Sincalide
  • Sodium Iodide
  • Solifenacin
  • Sufentanil
  • Suvorexant
  • Tacrine
  • Tasimelteon
  • Thalidomide
  • Thioridazine
  • Thiothixene
  • Tizanidine
  • Tolcapone
  • Tranylcypromine
  • Trastuzumab; Hyaluronidase
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Trimethobenzamide
  • Trospium
  • Vigabatrin
  • Vilazodone
  • Zaleplon
  • Ziconotide
  • Ziprasidone
  • Zolpidem
15585

Sign up to receive the trending updates and tons of Health Tips

Join SeekhealthZ and never miss the latest health information

15856
Scroll to Top