Triptorelin

What is Triptorelin

Triptorelin is a synthetic decapeptide agonist analog of gonadotropin-releasing hormone (GnRH) also known as luteinizing hormone releasing hormone (LHRH). Triptorelin is more potent than native GnRH.

Triptorelin has been widely used in Europe since 1986 as part of in vitro fertilization protocols and for treatment of hirsutism, endometriosis, or precocious puberty.

Triptorelin is FDA-approved in the United States for the palliative treatment of advanced prostate cancer and the treatment of central precocious puberty (CPP).

Psychiatric events have been reported in patients taking GnRH agonists; patients should be observed for a potential psychiatric event or worsening of psychiatric symptoms during triptorelin treatment.

Depression, including rare reports of suicidal ideation and attempt, has been reported with the use of GnRH agonists in children for CPP

Indications & Dosage

  • breast cancer
  • endometriosis
  • hirsutism
  • infertility
  • precocious puberty
  • prostate cancer

For the palliative treatment of advanced prostate cancer

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. anemia
  5. angioedema
  6. anorexia
  7. anxiety
  8. arthralgia
  9. asthenia
  10. back pain
  11. bone pain
  12. chest pain (unspecified)
  13. constipation
  14. cough
  15. depression
  16. diabetes mellitus
  17. diarrhea
  18. dizziness
  19. dyspepsia
  20. dyspnea
  21. dysuria
  22. edema
  23. elevated hepatic enzymes
  24. emotional lability
  25. fatigue
  26. gynecomastia
  27. headache
  28. hematuria
  29. hot flashes
  30. hyperglycemia
  31. hypertension
  32. impotence (erectile dysfunction)
  33. infection
  34. influenza
  35. injection site reaction
  36. insomnia
  37. libido decrease
  38. muscle paralysis
  39. myalgia
  40. myocardial infarction
  41. nausea
  42. ocular pain
  43. osteopenia
  44. osteoporosis
  45. peripheral edema
  46. peripheral neuropathy
  47. pharyngitis
  48. phlebitis
  49. pituitary apoplexy
  50. pneumonitis
  51. pruritus
  52. pulmonary embolism
  53. rash
  54. seizures
  55. sinusitis
  56. spinal cord compression
  57. stroke
  58. suicidal ideation
  59. testicular atrophy
  60. thrombosis
  61. tumor flare
  62. urinary retention
  63. urticaria
  64. vaginal bleeding
  65. visual impairment
  66. vomiting
  67. weakness

Monitoring Parameters

  • blood glucose
  • bone age determination
  • ECG
  • glycosylated hemoglobin A1c (HbA1c)
  • growth rate
  • serum electrolytes
  • serum gonadotropin concentrations
  • serum testosterone

Contraindications

  • alcoholism
  • bradycardia
  • brain tumor
  • breast-feeding
  • cardiac arrhythmias
  • cardiac disease
  • cerebrovascular disease
  • coronary artery disease
  • depression
  • diabetes mellitus
  • dysfunctional uterine bleeding
  • females
  • geriatric
  • Gonadotropin-Releasing Hormone (GnRH) analogs hypersensitivity
  • heart failure
  • hypertension
  • hypocalcemia
  • hypokalemia
  • hypomagnesemia
  • infertility
  • long QT syndrome
  • malnutrition
  • menstruation
  • myocardial infarction
  • osteoporosis
  • pituitary insufficiency
  • pregnancy
  • psychiatric event
  • QT prolongation
  • renal impairment
  • seizure disorder
  • spinal cord compression
  • suicidal ideation
  • thyroid disease
  • urinary tract obstruction
  • vaginal bleeding

Interactions

  • Alfuzosin
  • Amiodarone
  • Amoxapine
  • Amoxicillin; Clarithromycin; Lansoprazole
  • Amoxicillin; Clarithromycin; Omeprazole
  • Anagrelide
  • Androgens
  • Apomorphine
  • Aripiprazole
  • Arsenic Trioxide
  • Artemether; Lumefantrine
  • Asenapine
  • Atomoxetine
  • Azithromycin
  • Bedaquiline
  • Bismuth Subcitrate Potassium; Metronidazole; Tetracycline
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Brexpiprazole
  • Buprenorphine
  • Buprenorphine; Naloxone
  • Cariprazine
  • Ceritinib
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clofazimine
  • Clozapine
  • Codeine; Phenylephrine; Promethazine
  • Codeine; Promethazine
  • Crizotinib
  • Dasatinib
  • Desflurane
  • Deutetrabenazine
  • Dextromethorphan; Promethazine
  • Dextromethorphan; Quinidine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Dolutegravir; Rilpivirine
  • Donepezil
  • Donepezil; Memantine
  • Dronedarone
  • Droperidol
  • Efavirenz
  • Efavirenz; Emtricitabine; Tenofovir
  • Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
  • Eliglustat
  • Emtricitabine; Rilpivirine; Tenofovir alafenamide
  • Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
  • Encorafenib
  • Enflurane
  • Entrectinib
  • Eribulin
  • Erythromycin
  • Erythromycin; Sulfisoxazole
  • Escitalopram
  • Ezogabine
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluoxetine; Olanzapine
  • Fluphenazine
  • Fluvoxamine
  • Foscarnet
  • Gemifloxacin
  • Gemtuzumab Ozogamicin
  • Gilteritinib
  • Glasdegib
  • Granisetron
  • Halogenated Anesthetics
  • Haloperidol
  • Halothane
  • Hydrochlorothiazide, HCTZ; Methyldopa
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Inotuzumab Ozogamicin
  • Isoflurane
  • Itraconazole
  • Ivosidenib
  • Ketoconazole
  • Lapatinib
  • Lefamulin
  • Lenvatinib
  • Levofloxacin
  • Lithium
  • Lofexidine
  • Long-acting beta-agonists
  • Loperamide
  • Loperamide; Simethicone
  • Lopinavir; Ritonavir
  • Lorcaserin
  • Loxapine
  • Macimorelin
  • Maprotiline
  • Mefloquine
  • Meperidine; Promethazine
  • Methadone
  • Methyldopa
  • Metoclopramide
  • Metronidazole
  • Midostaurin
  • Mifepristone
  • Mirtazapine
  • Molindone
  • Moxifloxacin
  • Nilotinib
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ondansetron
  • Osilodrostat
  • Osimertinib
  • Oxaliplatin
  • Ozanimod
  • Paliperidone
  • Panobinostat
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Perphenazine; Amitriptyline
  • Phenylephrine; Promethazine
  • Pimavanserin
  • Pimozide
  • Pitolisant
  • Posaconazole
  • Primaquine
  • Procainamide
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Quetiapine
  • Quinidine
  • Quinine
  • Ramelteon
  • Ranolazine
  • Reserpine
  • Ribociclib
  • Ribociclib; Letrozole
  • Rilpivirine
  • Risperidone
  • Romidepsin
  • Saquinavir
  • Selpercatinib
  • Sertraline
  • Sevoflurane
  • Short-acting beta-agonists
  • Siponimod
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Thioridazine
  • Thiothixene
  • Tolterodine
  • Toremifene
  • Trandolapril; Verapamil
  • Trazodone
  • Tricyclic antidepressants
  • Trifluoperazine
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Verapamil
  • Voriconazole
  • Vorinostat
  • Ziprasidone
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