Sulfinpyrazone

What is Sulfinpyrazone

Sulfinpyrazone is an oral uricosuric agent (pyrazolone derivative) used to treat chronic or intermittent gouty arthritis.

Sulfinpyrazone is not intended for the treatment of acute attacks because it lacks therapeutically useful analgesic and anti-inflammatory effects.

Brand Name

Anturane

Side Effects

  1. agranulocytosis
  2. anemia
  3. aplastic anemia
  4. arthralgia
  5. bronchospasm
  6. dyspepsia
  7. edema
  8. gastritis
  9. GI bleeding
  10. hematuria
  11. interstitial nephritis
  12. leukopenia
  13. nausea
  14. nephrolithiasis
  15. rash
  16. renal failure (unspecified)
  17. renal tubular obstruction
  18. thrombocytopenia
  19. tinnitus
  20. vertigo
  21. vomiting

Monitoring Parameters

  • CBC
  • serum creatinine
  • serum uric acid

Contraindications

  • agranulocytosis
  • anemia
  • anticoagulant therapy
  • bone marrow suppression
  • breast-feeding
  • gastritis
  • geriatric
  • hematological disease
  • hepatic disease
  • leukopenia
  • nephrolithiasis
  • NSAID hypersensitivity
  • peptic ulcer disease
  • pregnancy
  • renal disease
  • renal failure
  • renal impairment
  • salicylate hypersensitivity
  • thrombocytopenia

Interactions

  • Abciximab
  • Acetaminophen
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan
  • Acetaminophen; Dextromethorphan; Doxylamine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Diphenhydramine
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pentazocine
  • Acetaminophen; Propoxyphene
  • Acetaminophen; Pseudoephedrine
  • Acetaminophen; Tramadol
  • Allopurinol
  • Aminosalicylate sodium, Aminosalicylic acid
  • Anagrelide
  • Anticoagulants
  • Antithrombin III
  • Apixaban
  • Argatroban
  • Aspirin, ASA
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Carisoprodol
  • Aspirin, ASA; Carisoprodol; Codeine
  • Aspirin, ASA; Citric Acid; Sodium Bicarbonate
  • Aspirin, ASA; Dipyridamole
  • Aspirin, ASA; Omeprazole
  • Aspirin, ASA; Oxycodone
  • Aspirin, ASA; Pravastatin
  • Atropine; Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Benzhydrocodone; Acetaminophen
  • Benzoic Acid; Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate
  • Betrixaban
  • Bismuth Subsalicylate
  • Bismuth Subsalicylate; Metronidazole; Tetracycline
  • Bivalirudin
  • Bosentan
  • Cholestyramine
  • Choline Salicylate; Magnesium Salicylate
  • Cilostazol
  • Clopidogrel
  • Colchicine
  • Colchicine; Probenecid
  • Cyclosporine
  • Dabigatran
  • Dalteparin
  • Danaparoid
  • Desirudin
  • Diazoxide
  • Dipyridamole
  • Dronabinol
  • Edoxaban
  • Enoxaparin
  • Eptifibatide
  • Ethacrynic Acid
  • Ethambutol
  • Fluvastatin
  • Fondaparinux
  • food
  • Fosphenytoin
  • Glimepiride; Rosiglitazone
  • Guanidine
  • Heparin
  • Hydrochlorothiazide, HCTZ; Triamterene
  • Hydroxyurea
  • Hyoscyamine; Methenamine; Methylene Blue; Phenyl Salicylate; Sodium Biphosphate
  • Insulins
  • Isoniazid, INH; Pyrazinamide, PZA; Rifampin
  • Lepirudin
  • Lesinurad
  • Lesinurad; Allopurinol
  • Magnesium Salicylate
  • Mecamylamine
  • Metformin; Rosiglitazone
  • Mycophenolate
  • Nateglinide
  • Nitrofurantoin
  • Nonsteroidal antiinflammatory drugs
  • Pegloticase
  • Pentosan
  • Phenytoin
  • Platelet Inhibitors
  • Prasugrel
  • Probenecid
  • Pyrazinamide, PZA
  • Ramelteon
  • Rivaroxaban
  • Rosiglitazone
  • Salicylates
  • Salsalate
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfisoxazole
  • Sulfonylureas
  • Terbinafine
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thrombolytic Agents
  • Ticagrelor
  • Ticlopidine
  • Tinzaparin
  • Tirofiban
  • Trandolapril; Verapamil
  • Triamterene
  • Verapamil
  • Vorapaxar
  • Voriconazole
  • Warfarin