Regadenoson

What is Regadenoson

Regadenoson is an A2A adenosine receptor agonist that acts as a coronary vasodilator and is used as a pharmacologic stress agent in radionuclide myocardial perfusion imaging.

Regadenoson can be used as an alternative to adenosine for diagnosing coronary artery disease.

Brand Name

Lexiscan

Indications

  • coronary artery disease diagnosis

For use in radionuclide myocardial perfusion imaging for coronary artery disease diagnosis in patients unable to undergo adequate exercise stress

Side Effects

  1. abdominal pain
  2. anaphylactic shock
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. asystole
  7. atrial fibrillation
  8. atrial flutter
  9. AV block
  10. back pain
  11. bradycardia
  12. bronchospasm
  13. cardiac arrest
  14. chest pain (unspecified)
  15. diarrhea
  16. dizziness
  17. dysgeusia
  18. dyspnea
  19. fecal incontinence
  20. flushing
  21. headache
  22. hypertension
  23. hypotension
  24. intracranial bleeding
  25. musculoskeletal pain
  26. myalgia
  27. myocardial infarction
  28. nausea
  29. premature atrial contractions (PACs)
  30. premature ventricular contractions (PVCs)
  31. QT prolongation
  32. rash
  33. respiratory arrest
  34. seizures
  35. sinus tachycardia
  36. stroke
  37. syncope
  38. tachypnea
  39. tremor
  40. urticaria
  41. vomiting
  42. wheezing

Monitoring Parameters

  • ECG

Contraindications

  • angina
  • asthma
  • autonomic neuropathy
  • AV block
  • bradycardia
  • breast-feeding
  • cardiac arrest
  • cardiac disease
  • chronic obstructive pulmonary disease (COPD)
  • geriatric
  • hypotension
  • hypovolemia
  • myocardial infarction
  • pericardial effusion
  • pericarditis
  • pregnancy
  • pulmonary disease
  • pulmonary edema
  • respiratory arrest
  • seizures
  • sick sinus syndrome
  • valvular heart disease
  • ventricular fibrillation

Interactions

  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Aspirin, ASA; Butalbital; Caffeine
  • Aspirin, ASA; Butalbital; Caffeine; Codeine
  • Aspirin, ASA; Caffeine; Dihydrocodeine
  • Aspirin, ASA; Caffeine; Orphenadrine
  • Aspirin, ASA; Dipyridamole
  • Caffeine
  • Caffeine; Ergotamine
  • Digoxin
  • Dipyridamole
  • Green Tea
  • Nicotine
  • Theophylline, Aminophylline
  • tobacco
  • Trandolapril; Verapamil
  • Verapamil
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