What is Trandolapril and Verapamil combination medicine
Trandolapril, an angiotensin converting enzyme inhibitor, and verapamil, a calcium-channel blocker are used in combination as second-line treatment for hypertension.
The drugs have complimentary mechanisms of action which decrease peripheral resistance and lower blood pressure.
The combination of oral verapamil and trandolapril demonstrates greater antihypertensive and antiproteinuric effects than either agent alone.
TARKA® contains immediate-release trandolapril and extended-release verapamil. TARKA® is dosed once daily, and may be convenient for patients who are receiving both drugs separately.
TARKA® was approved by the FDA in November 1996.
Brand Name
Tarka
Indications
- hypertension
For the treatment of hypertension in patients who do not respond to monotherapy
Side Effects
- agranulocytosis
- alopecia
- anaphylactoid reactions
- angina
- angioedema
- anxiety
- aplastic anemia
- arthralgia
- atrial fibrillation
- AV block
- azotemia
- blurred vision
- bradycardia
- bundle-branch block
- chest pain (unspecified)
- cholestasis
- confusion
- constipation
- cough
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- ecchymosis
- edema
- elevated hepatic enzymes
- epistaxis
- erythema multiforme
- exfoliative dermatitis
- fatigue
- fever
- flushing
- galactorrhea
- gingival hyperplasia
- glomerulonephritis
- gout
- gynecomastia
- headache
- heart failure
- hematuria
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperkalemia
- hyperkeratosis
- hyperprolactinemia
- hypoesthesia
- hypotension
- ileus
- impotence (erectile dysfunction)
- increased urinary frequency
- insomnia
- jaundice
- laryngeal edema
- leukopenia
- libido decrease
- malaise
- myalgia
- myocardial infarction
- nausea
- neutropenia
- nocturia
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pemphigus
- peripheral edema
- peripheral vasodilation
- photosensitivity
- pneumonitis
- polyuria
- premature ventricular contractions (PVCs)
- proteinuria
- pruritus
- psychosis
- pulmonary edema
- rash
- renal tubular necrosis
- sinus tachycardia
- Stevens-Johnson syndrome
- stroke
- syncope
- teratogenesis
- thrombocytopenia
- tinnitus
- toxic epidermal necrolysis
- urticaria
- ventricular fibrillation
- vertigo
- weakness
- xerostomia
Monitoring Parameters
- blood pressure
- heart rate
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- acute myocardial infarction
- angioedema
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- atrial fibrillation
- atrial flutter
- autoimmune disease
- AV block
- Black patients
- bone marrow suppression
- bradycardia
- breast-feeding
- cardiogenic shock
- cardiomyopathy
- cerebrovascular disease
- collagen-vascular disease
- constipation
- coronary artery disease
- diabetes mellitus
- dialysis
- fecal impaction
- geriatric
- GI obstruction
- heart failure
- hepatic disease
- hereditary angioedema
- history of angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- ileus
- immunosuppression
- low-density lipoprotein apheresis
- Lown-Ganong-Levine syndrome
- myasthenia gravis
- neuromuscular disease
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- sick sinus syndrome
- surgery
- systemic lupus erythematosus (SLE)
- ventricular dysfunction
- ventricular tachycardia
- Wolff-Parkinson-White syndrome
Interactions
- Abemaciclib
- Acalabrutinib
- Acebutolol
- Acetaminophen; Aspirin, ASA; Caffeine
- Acetaminophen; Butalbital
- Acetaminophen; Butalbital; Caffeine
- Acetaminophen; Butalbital; Caffeine; Codeine
- Acetaminophen; Caffeine
- Acetaminophen; Caffeine; Dihydrocodeine
- Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
- Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Codeine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Hydrocodone
- Acetaminophen; Oxycodone
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Afatinib
- Aldesleukin, IL-2
- Alemtuzumab
- Alfentanil
- Alfuzosin
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Almotriptan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprazolam
- Alprostadil
- Alvimopan
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Aminolevulinic Acid
- Amiodarone
- Amitriptyline; Chlordiazepoxide
- Amlodipine
- Amlodipine; Atorvastatin
- Amlodipine; Benazepril
- Amlodipine; Celecoxib
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amoxicillin; Clarithromycin; Lansoprazole
- Amoxicillin; Clarithromycin; Omeprazole
- Amphetamine; Dextroamphetamine Salts
- Amprenavir
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Apalutamide
- Apixaban
- Apomorphine
- Apraclonidine
- Aprepitant, Fosaprepitant
- Aprotinin
- Aripiprazole
- Asenapine
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Atazanavir
- Atazanavir; Cobicistat
- Atenolol
- Atenolol; Chlorthalidone
- Atorvastatin
- Atorvastatin; Ezetimibe
- Atropine; Hyoscyamine; Phenobarbital; Scopolamine
- Avanafil
- Avapritinib
- Azathioprine
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
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- Belladonna Alkaloids; Ergotamine; Phenobarbital
- Bendroflumethiazide; Nadolol
- Benzhydrocodone; Acetaminophen
- Benzonatate
- Benzphetamine
- Betaxolol
- Betrixaban
- Bictegravir; Emtricitabine; Tenofovir Alafenamide
- Bisoprolol
- Bisoprolol; Hydrochlorothiazide, HCTZ
- Boceprevir
- Bortezomib
- Bosentan
- Bosutinib
- Brexpiprazole
- Brigatinib
- Brimonidine; Timolol
- Bromocriptine
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Guaifenesin; Hydrocodone
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Budesonide
- Budesonide; Formoterol
- Bupivacaine
- Bupivacaine Liposomal
- Bupivacaine; Lidocaine
- Buprenorphine
- Buprenorphine; Naloxone
- Buspirone
- Butabarbital
- Cabergoline
- Cabozantinib
- Caffeine
- Caffeine; Ergotamine
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan
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- Cannabidiol
- Carbamazepine
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carteolol
- Carvedilol
- Celecoxib
- Ceritinib
- Cerivastatin
- Cetirizine; Pseudoephedrine
- Cevimeline
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chlordiazepoxide
- Chlordiazepoxide; Clidinium
- Chloroprocaine
- Chlorpheniramine; Codeine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Chlorthalidone; Clonidine
- Cilostazol
- Cimetidine
- Cinacalcet
- Cisapride
- Cisplatin
- Citalopram
- Clarithromycin
- Clofarabine
- Clonazepam
- Clonidine
- Clorazepate
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cobicistat
- Cobimetinib
- Cocaine
- Codeine
- Codeine; Guaifenesin
- Codeine; Phenylephrine; Promethazine
- Codeine; Promethazine
- Colchicine
- Colchicine; Probenecid
- Colesevelam
- Conivaptan
- Conjugated Estrogens
- Conjugated Estrogens; Bazedoxifene
- Conjugated Estrogens; Medroxyprogesterone
- Crizotinib
- Cyclobenzaprine
- Cyclophosphamide
- Cyclosporine
- Dabigatran
- Daclatasvir
- Danazol
- Dantrolene
- Dapagliflozin; Metformin
- Dapagliflozin; Saxagliptin
- Darifenacin
- Darunavir
- Darunavir; Cobicistat
- Darunavir; Cobicistat; Emtricitabine; Tenofovir alafenamide
- Dasabuvir; Ombitasvir; Paritaprevir; Ritonavir
- Deferasirox
- Deflazacort
- Degarelix
- Delavirdine
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmedetomidine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazepam
- Diazoxide
- Diclofenac
- Diclofenac; Misoprostol
- Dienogest; Estradiol valerate
- Diethylpropion
- Diflunisal
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Dihydroergotamine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Ibuprofen
- Diphenhydramine; Naproxen
- Diphenhydramine; Phenylephrine
- Disopyramide
- Dofetilide
- Dolasetron
- Dolutegravir; Rilpivirine
- Donepezil
- Donepezil; Memantine
- Doravirine; Lamivudine; Tenofovir disoproxil fumarate
- Dorzolamide; Timolol
- Doxazosin
- Doxercalciferol
- Doxorubicin
- Dronabinol
- Dronedarone
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Dutasteride; Tamsulosin
- Duvelisib
- Edoxaban
- Efavirenz
- Efavirenz; Emtricitabine; Tenofovir
- Efavirenz; Lamivudine; Tenofovir Disoproxil Fumarate
- Elagolix; Estradiol; Norethindrone acetate
- Elbasvir; Grazoprevir
- Eletriptan
- Elexacaftor; tezacaftor; ivacaftor
- Eliglustat
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Alafenamide
- Elvitegravir; Cobicistat; Emtricitabine; Tenofovir Disoproxil Fumarate
- Empagliflozin
- Empagliflozin; Linagliptin
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Emtricitabine; Rilpivirine; Tenofovir alafenamide
- Emtricitabine; Rilpivirine; Tenofovir disoproxil fumarate
- Emtricitabine; Tenofovir alafenamide
- Emtricitabine; Tenofovir disoproxil fumarate
- Encorafenib
- Enflurane
- Entecavir
- Entrectinib
- Enzalutamide
- Ephedrine
- Epirubicin
- Eplerenone
- Epoprostenol
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ergoloid Mesylates
- Ergonovine
- Ergotamine
- Erlotinib
- Ertugliflozin; Metformin
- Erythromycin
- Erythromycin; Sulfisoxazole
- Esmolol
- Esomeprazole; Naproxen
- Estazolam
- Esterified Estrogens
- Esterified Estrogens; Methyltestosterone
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Estradiol; Levonorgestrel
- Estradiol; Norethindrone
- Estradiol; Norgestimate
- Estradiol; Progesterone
- Estropipate
- Eszopiclone
- Ethanol
- Ethinyl Estradiol
- Ethinyl Estradiol; Desogestrel
- Ethinyl Estradiol; Ethynodiol Diacetate
- Ethinyl Estradiol; Etonogestrel
- Ethinyl Estradiol; Levonorgestrel
- Ethinyl Estradiol; Levonorgestrel; Ferrous bisglycinate
- Ethinyl Estradiol; Levonorgestrel; Folic Acid; Levomefolate
- Ethinyl Estradiol; Norelgestromin
- Ethinyl Estradiol; Norethindrone
- Ethinyl Estradiol; Norethindrone Acetate
- Ethinyl Estradiol; Norethindrone Acetate; Ferrous fumarate
- Ethinyl Estradiol; Norethindrone; Ferrous fumarate
- Ethinyl Estradiol; Norgestimate
- Ethinyl Estradiol; Norgestrel
- Ethosuximide
- Etodolac
- Etomidate
- Etonogestrel
- Etravirine
- Everolimus
- Ezetimibe; Simvastatin
- Famotidine; Ibuprofen
- Fedratinib
- Fenoprofen
- Fentanyl
- Fesoterodine
- Fexofenadine; Pseudoephedrine
- Fingolimod
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Flecainide
- Flibanserin
- Fluconazole
- Fluorescein
- Fluoxetine
- Fluoxetine; Olanzapine
- Flurazepam
- Flurbiprofen
- Fluticasone; Umeclidinium; Vilanterol
- Fluvoxamine
- food
- Fosamprenavir
- Fospropofol
- General anesthetics
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Ginseng, Panax ginseng
- Glecaprevir; Pibrentasvir
- Glipizide; Metformin
- Glyburide; Metformin
- Gold
- Goserelin
- grapefruit juice
- Green Tea
- Guaifenesin; Hydrocodone
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Guanfacine
- Halofantrine
- Haloperidol
- Halothane
- Heparin
- Histrelin
- Homatropine; Hydrocodone
- Hydantoins
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Metoprolol
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Propranolol
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone
- Hydrocodone; Ibuprofen
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Hydroxyprogesterone
- Ibrutinib
- Ibuprofen
- Ibuprofen; Oxycodone
- Ibuprofen; Pseudoephedrine
- Icatibant
- Idelalisib
- Ifosfamide
- Iloperidone
- Iloprost
- Imatinib
- Imipramine
- Incretin Mimetics
- Indacaterol
- Indacaterol; Glycopyrrolate
- Indapamide
- Indinavir
- Indomethacin
- Insulins
- Intravenous Lipid Emulsions
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Iron Dextran
- Isavuconazonium
- Isocarboxazid
- Isoflurane
- Isoniazid, INH; Pyrazinamide, PZA; Rifampin
- Isoniazid, INH; Rifampin
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isosulfan Blue
- Itraconazole
- Ivabradine
- Ivacaftor
- Ivosidenib
- Ixabepilone
- Kanamycin
- Ketamine
- Ketoconazole
- Ketoprofen
- Ketorolac
- Labetalol
- Lacosamide
- Lamivudine; Tenofovir Disoproxil Fumarate
- Lanreotide
- Lansoprazole; Naproxen
- Lanthanum Carbonate
- Lapatinib
- Lasmiditan
- Lefamulin
- Lemborexant
- Letermovir
- Leuprolide
- Leuprolide; Norethindrone
- Levodopa
- Levomethadyl
- Lidocaine
- Lidocaine; Prilocaine
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Lofexidine
- Lomitapide
- Loop diuretics
- Loperamide
- Loperamide; Simethicone
- Lopinavir; Ritonavir
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin
- Lovastatin; Niacin
- Lumacaftor; Ivacaftor
- Lumacaftor; Ivacaftor
- Lumateperone
- Lurasidone
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Maraviroc
- Meclofenamate Sodium
- Mefenamic Acid
- Mefloquine
- Meglitinides
- Melatonin
- Meloxicam
- Mephobarbital
- Mestranol; Norethindrone
- Metformin
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- Metformin; Rosiglitazone
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- Metformin; Sitagliptin
- Methadone
- Methamphetamine
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- Metoprolol
- Midazolam
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- Milrinone
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- Naproxen
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- Nebivolol
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- Neuromuscular blockers
- Nevirapine
- Niacin, Niacinamide
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- Nifedipine
- Nilotinib
- Nintedanib
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Octreotide
- Olanzapine
- Olaparib
- Olmesartan
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- Omeprazole; Amoxicillin; Rifabutin
- Oritavancin
- Osimertinib
- Oxaprozin
- Oxcarbazepine
- Oxybutynin
- Oxycodone
- Oxymetazoline
- Paclitaxel
- Paliperidone
- Paricalcitol
- Pasireotide
- Pazopanib
- Pemigatinib
- Penbutolol
- Pentobarbital
- Pentoxifylline
- Perindopril; Amlodipine
- Pexidartinib
- Phenelzine
- Phenobarbital
- Phenoxybenzamine
- Phentolamine
- Phenylephrine
- Phenylephrine; Promethazine
- Photosensitizing agents (topical)
- Pimozide
- Pindolol
- Piroxicam
- Polyethylene Glycol; Electrolytes
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- Posaconazole
- Potassium
- Pramlintide
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- Primidone
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- Quazepam
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- Quinidine
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- Ramelteon
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- Rasagiline
- Red Yeast Rice
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- Repaglinide
- Ribociclib
- Ribociclib; Letrozole
- Rifabutin
- Rifampin
- Rifapentine
- Rifaximin
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- Rimegepant
- Risperidone
- Ritonavir
- Rivaroxaban
- Rofecoxib
- Romidepsin
- Ruxolitinib
- Sacubitril; Valsartan
- Salicylates
- Sapropterin
- Saxagliptin
- Secobarbital
- Segesterone Acetate; Ethinyl Estradiol
- Selegiline
- Selpercatinib
- Selumetinib
- Sevoflurane
- SGLT2 Inhibitors
- Sildenafil
- Silodosin
- Simeprevir
- Simvastatin
- Simvastatin; Sitagliptin
- Sincalide
- Siponimod
- Sirolimus
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- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sonidegib
- Sorafenib
- Sotalol
- Spironolactone
- St. John’s Wort, Hypericum perforatum
- Sufentanil
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- Sulindac
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- Tacrolimus
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- Temsirolimus
- Tenofovir Alafenamide
- Tenofovir Alafenamide
- Tenofovir, PMPA
- Terazosin
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- Tetracaine
- Tezacaftor; Ivacaftor
- Thalidomide
- Theophylline, Aminophylline
- Thiazide diuretics
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- Thiopental
- Thiothixene
- Ticagrelor
- Timolol
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- Tizanidine
- Tolmetin
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- Tolvaptan
- Topotecan
- Tranylcypromine
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- Treprostinil
- Tretinoin, ATRA
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- Venetoclax
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- Vorapaxar
- Voriconazole
- Yohimbine
- Zafirlukast
- Zanubrutinib
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- Ziprasidone
- Zolpidem
- Zonisamide
