Trandolapril and Verapamil

What is Trandolapril and Verapamil combination medicine

Trandolapril, an angiotensin converting enzyme inhibitor, and verapamil, a calcium-channel blocker are used in combination as second-line treatment for hypertension.

The drugs have complimentary mechanisms of action which decrease peripheral resistance and lower blood pressure.

The combination of oral verapamil and trandolapril demonstrates greater antihypertensive and antiproteinuric effects than either agent alone.

TARKA® contains immediate-release trandolapril and extended-release verapamil. TARKA® is dosed once daily, and may be convenient for patients who are receiving both drugs separately.

TARKA® was approved by the FDA in November 1996.

Brand Name

Tarka

Indications

  • hypertension

For the treatment of hypertension in patients who do not respond to monotherapy

Side Effects

  1. agranulocytosis
  2. alopecia
  3. anaphylactoid reactions
  4. angina
  5. angioedema
  6. anxiety
  7. aplastic anemia
  8. arthralgia
  9. atrial fibrillation
  10. AV block
  11. azotemia
  12. blurred vision
  13. bradycardia
  14. bundle-branch block
  15. chest pain (unspecified)
  16. cholestasis
  17. confusion
  18. constipation
  19. cough
  20. diarrhea
  21. dizziness
  22. drowsiness
  23. dyspepsia
  24. dyspnea
  25. ecchymosis
  26. edema
  27. elevated hepatic enzymes
  28. epistaxis
  29. erythema multiforme
  30. exfoliative dermatitis
  31. fatigue
  32. fever
  33. flushing
  34. galactorrhea
  35. gingival hyperplasia
  36. glomerulonephritis
  37. gout
  38. gynecomastia
  39. headache
  40. heart failure
  41. hematuria
  42. hemolytic anemia
  43. hepatic failure
  44. hepatic necrosis
  45. hepatitis
  46. hyperkalemia
  47. hyperkeratosis
  48. hyperprolactinemia
  49. hypoesthesia
  50. hypotension
  51. ileus
  52. impotence (erectile dysfunction)
  53. increased urinary frequency
  54. insomnia
  55. jaundice
  56. laryngeal edema
  57. leukopenia
  58. libido decrease
  59. malaise
  60. myalgia
  61. myocardial infarction
  62. nausea
  63. neutropenia
  64. nocturia
  65. palpitations
  66. pancreatitis
  67. pancytopenia
  68. paresthesias
  69. pemphigus
  70. peripheral edema
  71. peripheral vasodilation
  72. photosensitivity
  73. pneumonitis
  74. polyuria
  75. premature ventricular contractions (PVCs)
  76. proteinuria
  77. pruritus
  78. psychosis
  79. pulmonary edema
  80. rash
  81. renal tubular necrosis
  82. sinus tachycardia
  83. Stevens-Johnson syndrome
  84. stroke
  85. syncope
  86. teratogenesis
  87. thrombocytopenia
  88. tinnitus
  89. toxic epidermal necrolysis
  90. urticaria
  91. ventricular fibrillation
  92. vertigo
  93. weakness
  94. xerostomia

Monitoring Parameters

  • blood pressure
  • heart rate
  • serum creatinine/BUN
  • serum potassium
  • serum sodium

Contraindications

  • ACE-inhibitor induced angioedema
  • acute myocardial infarction
  • angioedema
  • Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
  • aortic stenosis
  • atrial fibrillation
  • atrial flutter
  • autoimmune disease
  • AV block
  • Black patients
  • bone marrow suppression
  • bradycardia
  • breast-feeding
  • cardiogenic shock
  • cardiomyopathy
  • cerebrovascular disease
  • collagen-vascular disease
  • constipation
  • coronary artery disease
  • diabetes mellitus
  • dialysis
  • fecal impaction
  • geriatric
  • GI obstruction
  • heart failure
  • hepatic disease
  • hereditary angioedema
  • history of angioedema
  • hymenoptera venom (insect sting) allergy desensitization
  • hyperkalemia
  • hyponatremia
  • hypotension
  • hypovolemia
  • ileus
  • immunosuppression
  • low-density lipoprotein apheresis
  • Lown-Ganong-Levine syndrome
  • myasthenia gravis
  • neuromuscular disease
  • pregnancy
  • renal artery stenosis
  • renal disease
  • renal failure
  • renal impairment
  • scleroderma
  • sick sinus syndrome
  • surgery
  • systemic lupus erythematosus (SLE)
  • ventricular dysfunction
  • ventricular tachycardia
  • Wolff-Parkinson-White syndrome

Interactions

  • Abemaciclib
  • Acalabrutinib
  • Acebutolol
  • Acetaminophen; Aspirin, ASA; Caffeine
  • Acetaminophen; Butalbital
  • Acetaminophen; Butalbital; Caffeine
  • Acetaminophen; Butalbital; Caffeine; Codeine
  • Acetaminophen; Caffeine
  • Acetaminophen; Caffeine; Dihydrocodeine
  • Acetaminophen; Caffeine; Magnesium Salicylate; Phenyltoloxamine
  • Acetaminophen; Caffeine; Phenyltoloxamine; Salicylamide
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
  • Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
  • Acetaminophen; Codeine
  • Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
  • Acetaminophen; Dextromethorphan; Phenylephrine
  • Acetaminophen; Dextromethorphan; Pseudoephedrine
  • Acetaminophen; Dichloralphenazone; Isometheptene
  • Acetaminophen; Guaifenesin; Phenylephrine
  • Acetaminophen; Hydrocodone
  • Acetaminophen; Oxycodone
  • Acetaminophen; Pseudoephedrine
  • Acrivastine; Pseudoephedrine
  • Afatinib
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  • Alemtuzumab
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  • Amlodipine; Olmesartan
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  • Ethinyl Estradiol; Norethindrone Acetate
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  • Ethosuximide
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  • food
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  • grapefruit juice
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  • Hydrocodone
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  • Selpercatinib
  • Selumetinib
  • Sevoflurane
  • SGLT2 Inhibitors
  • Sildenafil
  • Silodosin
  • Simeprevir
  • Simvastatin
  • Simvastatin; Sitagliptin
  • Sincalide
  • Siponimod
  • Sirolimus
  • Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
  • Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
  • Sofosbuvir; Velpatasvir
  • Sofosbuvir; Velpatasvir; Voxilaprevir
  • Sonidegib
  • Sorafenib
  • Sotalol
  • Spironolactone
  • St. John’s Wort, Hypericum perforatum
  • Sufentanil
  • Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
  • Sulfinpyrazone
  • Sulfonylureas
  • Sulindac
  • Suvorexant
  • Tacrolimus
  • Tadalafil
  • Talazoparib
  • Tamsulosin
  • Tasimelteon
  • Tazemetostat
  • Telaprevir
  • Telavancin
  • Telbivudine
  • Telithromycin
  • Telmisartan
  • Telotristat Ethyl
  • Temsirolimus
  • Tenofovir Alafenamide
  • Tenofovir Alafenamide
  • Tenofovir, PMPA
  • Terazosin
  • Terbinafine
  • Tetrabenazine
  • Tetracaine
  • Tezacaftor; Ivacaftor
  • Thalidomide
  • Theophylline, Aminophylline
  • Thiazide diuretics
  • Thiazolidinediones
  • Thiopental
  • Thiothixene
  • Ticagrelor
  • Timolol
  • Tipranavir
  • Tizanidine
  • Tolmetin
  • Tolterodine
  • Tolvaptan
  • Topotecan
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Tretinoin, ATRA
  • Triamterene
  • Triazolam
  • Trimethoprim
  • Triptorelin
  • Tucatinib
  • Ubrogepant
  • Ulipristal
  • Umeclidinium
  • Umeclidinium; Vilanterol
  • Valdecoxib
  • Valsartan
  • Vardenafil
  • Vemurafenib
  • Venetoclax
  • Verteporfin
  • Vinblastine
  • Vincristine
  • Vincristine Liposomal
  • Vinorelbine
  • Vorapaxar
  • Voriconazole
  • Yohimbine
  • Zafirlukast
  • Zanubrutinib
  • Zileuton
  • Ziprasidone
  • Zolpidem
  • Zonisamide
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