What is Trandolapril
Trandolapril is an oral, non-sulfhydryl-containing angiotensin converting enzyme inhibitor (ACEI). It is a prodrug for trandolaprilat which is about 8 times as potent as trandolapril in inhibiting ACE.
Trandolapril is structurally similar to enalapril and both require hydrolysis for activity. Because of the pharmacokinetics of the active metabolite, trandolaprilat, trandolapril can be administered once daily.
Trandolapril is approved for the treatment of hypertension and is under investigation for prevention of sudden death post-MI. Data from the TRACE (Trandolapril Cardiac Evaluation) study suggest trandolapril can significantly reduce sudden death post-MI, and can decrease progression to severe heart failure, however, it did not reduce the risk of recurrent myocardial infarction.
Final approval for trandolapril as a single-entity was granted May 3, 1996. A combination product containing trandolapril and verapamil SR (Tarka(R)) has also been approved for the treatment of hypertension. Trandolapril is available as Odrik in France and Gopten in Germany.
Brand Name
Mavik
Indications
- heart failure
- hypertension
- postmyocardial infarction
Side Effects
- abdominal pain
- agranulocytosis
- alopecia
- anaphylactoid reactions
- angina
- angioedema
- anxiety
- arrhythmia exacerbation
- asthenia
- AV block
- azotemia
- bradycardia
- chest pain (unspecified)
- cholestasis
- constipation
- cough
- depression
- diaphoresis
- diarrhea
- dizziness
- drowsiness
- dyspepsia
- dyspnea
- edema
- elevated hepatic enzymes
- epistaxis
- fever
- flushing
- gastritis
- gout
- hallucinations
- heart failure
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hyperkalemia
- hyperuricemia
- hypocalcemia
- hyponatremia
- hypotension
- impotence (erectile dysfunction)
- infection
- insomnia
- jaundice
- laryngeal edema
- leukopenia
- libido decrease
- malaise
- muscle cramps
- musculoskeletal pain
- myalgia
- myocardial infarction
- nausea
- neutropenia
- oliguria
- palpitations
- pancreatitis
- pancytopenia
- paresthesias
- pemphigus
- pneumonitis
- pruritus
- rash
- renal failure (unspecified)
- Stevens-Johnson syndrome
- stroke
- syncope
- teratogenesis
- throat irritation
- thrombocytopenia
- toxic epidermal necrolysis
- ventricular tachycardia
- vertigo
- vomiting
- xerostomia
Monitoring Parameters
- blood pressure
- serum creatinine/BUN
- serum potassium
- serum sodium
Contraindications
- ACE-inhibitor induced angioedema
- angioedema
- Angiotensin-converting enzyme inhibitors (ACE inhibitors) hypersensitivity
- aortic stenosis
- autoimmune disease
- Black patients
- bone marrow suppression
- breast-feeding
- cardiomyopathy
- cerebrovascular disease
- children
- collagen-vascular disease
- coronary artery disease
- diabetes mellitus
- dialysis
- geriatric
- heart failure
- hepatic disease
- hereditary angioedema
- hymenoptera venom (insect sting) allergy desensitization
- hyperkalemia
- hyponatremia
- hypotension
- hypovolemia
- immunosuppression
- infants
- jaundice
- low-density lipoprotein apheresis
- neonates
- neutropenia
- pregnancy
- renal artery stenosis
- renal disease
- renal failure
- renal impairment
- scleroderma
- surgery
- systemic lupus erythematosus (SLE)
Interactions
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Phenylephrine
- Acetaminophen; Chlorpheniramine; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine
- Acetaminophen; Dextromethorphan; Guaifenesin; Phenylephrine
- Acetaminophen; Dextromethorphan; Phenylephrine
- Acetaminophen; Dextromethorphan; Pseudoephedrine
- Acetaminophen; Dichloralphenazone; Isometheptene
- Acetaminophen; Guaifenesin; Phenylephrine
- Acetaminophen; Pseudoephedrine
- Acrivastine; Pseudoephedrine
- Aldesleukin, IL-2
- Alemtuzumab
- Aliskiren
- Aliskiren; Amlodipine
- Aliskiren; Amlodipine; Hydrochlorothiazide, HCTZ
- Aliskiren; Hydrochlorothiazide, HCTZ
- Aliskiren; Valsartan
- Alogliptin; Metformin
- Alpha-glucosidase Inhibitors
- Alprostadil
- Amifostine
- Amiloride
- Amiloride; Hydrochlorothiazide, HCTZ
- Amlodipine; Hydrochlorothiazide, HCTZ; Olmesartan
- Amlodipine; Hydrochlorothiazide, HCTZ; Valsartan
- Amlodipine; Olmesartan
- Amlodipine; Telmisartan
- Amlodipine; Valsartan
- Amobarbital
- Amphetamine; Dextroamphetamine Salts
- Amyl Nitrite
- Angiotensin II
- Angiotensin II receptor antagonists
- Apomorphine
- Apraclonidine
- Aprotinin
- Aripiprazole
- Asenapine
- Azathioprine
- Azilsartan
- Azilsartan; Chlorthalidone
- Baclofen
- Benzphetamine
- Bosentan
- Brexpiprazole
- Brompheniramine; Carbetapentane; Phenylephrine
- Brompheniramine; Hydrocodone; Pseudoephedrine
- Brompheniramine; Pseudoephedrine
- Cabergoline
- Calcium Phosphate, Supersaturated
- Canagliflozin; Metformin
- Candesartan
- Candesartan; Hydrochlorothiazide, HCTZ
- Carbetapentane; Chlorpheniramine; Phenylephrine
- Carbetapentane; Diphenhydramine; Phenylephrine
- Carbetapentane; Guaifenesin; Phenylephrine
- Carbetapentane; Phenylephrine
- Carbetapentane; Phenylephrine; Pyrilamine
- Carbetapentane; Pseudoephedrine
- Carbidopa; Levodopa
- Carbidopa; Levodopa; Entacapone
- Carbinoxamine; Dextromethorphan; Pseudoephedrine
- Carbinoxamine; Hydrocodone; Phenylephrine
- Carbinoxamine; Hydrocodone; Pseudoephedrine
- Carbinoxamine; Phenylephrine
- Carbinoxamine; Pseudoephedrine
- Cariprazine
- Carvedilol
- Cetirizine; Pseudoephedrine
- Chlophedianol; Dexchlorpheniramine; Pseudoephedrine
- Chlophedianol; Guaifenesin; Phenylephrine
- Chloroprocaine
- Chlorpheniramine; Dextromethorphan; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Phenylephrine
- Chlorpheniramine; Dihydrocodeine; Pseudoephedrine
- Chlorpheniramine; Guaifenesin; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Hydrocodone; Phenylephrine
- Chlorpheniramine; Hydrocodone; Pseudoephedrine
- Chlorpheniramine; Phenylephrine
- Chlorpheniramine; Pseudoephedrine
- Clozapine
- Co-Enzyme Q10, Ubiquinone
- Cocaine
- Codeine; Phenylephrine; Promethazine
- Conivaptan
- Cyclophosphamide
- Cyclosporine
- Dapagliflozin; Metformin
- Desloratadine; Pseudoephedrine
- Dexchlorpheniramine; Dextromethorphan; Pseudoephedrine
- Dexmethylphenidate
- Dextromethorphan; Diphenhydramine; Phenylephrine
- Dextromethorphan; Guaifenesin; Phenylephrine
- Dextromethorphan; Guaifenesin; Pseudoephedrine
- Dextromethorphan; Quinidine
- Diazoxide
- Diethylpropion
- Digoxin
- Dihydrocodeine; Guaifenesin; Pseudoephedrine
- Diphenhydramine; Hydrocodone; Phenylephrine
- Diphenhydramine; Phenylephrine
- Drospirenone
- Drospirenone; Estradiol
- Drospirenone; Ethinyl Estradiol
- Drospirenone; Ethinyl Estradiol; Levomefolate
- Duloxetine
- Empagliflozin; Linagliptin; Metformin
- Empagliflozin; Metformin
- Enflurane
- Entecavir
- Ephedrine
- Eplerenone
- Eprosartan
- Eprosartan; Hydrochlorothiazide, HCTZ
- Ertugliflozin; Metformin
- Estradiol
- Estradiol Cypionate; Medroxyprogesterone
- Etomidate
- Everolimus
- Fexofenadine; Pseudoephedrine
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fluorescein
- Fluoxetine; Olanzapine
- Fospropofol
- General anesthetics
- Glipizide; Metformin
- Glyburide; Metformin
- Gold
- Guaifenesin; Hydrocodone; Pseudoephedrine
- Guaifenesin; Phenylephrine
- Guaifenesin; Pseudoephedrine
- Haloperidol
- Halothane
- Heparin
- Hydralazine; Isosorbide Dinitrate, ISDN
- Hydrochlorothiazide, HCTZ; Irbesartan
- Hydrochlorothiazide, HCTZ; Losartan
- Hydrochlorothiazide, HCTZ; Olmesartan
- Hydrochlorothiazide, HCTZ; Spironolactone
- Hydrochlorothiazide, HCTZ; Telmisartan
- Hydrochlorothiazide, HCTZ; Triamterene
- Hydrochlorothiazide, HCTZ; Valsartan
- Hydrocodone; Phenylephrine
- Hydrocodone; Potassium Guaiacolsulfonate; Pseudoephedrine
- Hydrocodone; Pseudoephedrine
- Ibuprofen; Pseudoephedrine
- Icatibant
- Iloperidone
- Iloprost
- Incretin Mimetics
- Indapamide
- Insulins
- Intravenous Lipid Emulsions
- Iohexol
- Iopamidol
- Iopromide
- Ioversol
- Irbesartan
- Iron Dextran
- Isocarboxazid
- Isoflurane
- Isoproterenol
- Isosorbide Dinitrate, ISDN
- Isosorbide Mononitrate
- Isosulfan Blue
- Kanamycin
- Ketamine
- Lanthanum Carbonate
- Levodopa
- Linagliptin; Metformin
- Lisdexamfetamine
- Lithium
- Loop diuretics
- Loratadine; Pseudoephedrine
- Losartan
- Lovastatin; Niacin
- Lurasidone
- Magnesium Salts
- Magnesium Sulfate; Potassium Sulfate; Sodium Sulfate
- Meglitinides
- Mestranol; Norethindrone
- Metformin
- Metformin; Pioglitazone
- Metformin; Repaglinide
- Metformin; Rosiglitazone
- Metformin; Saxagliptin
- Metformin; Sitagliptin
- Methamphetamine
- Methohexital
- Methylphenidate
- Milrinone
- Naproxen; Pseudoephedrine
- Nateglinide
- Nebivolol; Valsartan
- Nefazodone
- Nesiritide, BNP
- Niacin, Niacinamide
- Niacin; Simvastatin
- Nitrates
- Nitroglycerin
- Nitroprusside
- Non-Ionic Contrast Media
- Nonsteroidal antiinflammatory drugs
- Olanzapine
- Olmesartan
- Oxymetazoline
- Paliperidone
- Pentoxifylline
- Phenelzine
- Phenylephrine
- Phenylephrine; Promethazine
- Polyethylene Glycol; Electrolytes
- Polyethylene Glycol; Electrolytes; Ascorbic Acid
- Potassium
- Pramlintide
- Prazosin
- Pregabalin
- Procainamide
- Procaine
- Propofol
- Pseudoephedrine
- Quinidine
- Rasagiline
- Repaglinide
- Risperidone
- Sacubitril; Valsartan
- Salicylates
- Selegiline
- Sevoflurane
- SGLT2 Inhibitors
- Silodosin
- Sirolimus
- Sodium Phosphate Monobasic Monohydrate; Sodium Phosphate Dibasic Anhydrous
- Sodium picosulfate; Magnesium oxide; Anhydrous citric acid
- Spironolactone
- Sulfamethoxazole; Trimethoprim, SMX-TMP, Cotrimoxazole
- Sulfonylureas
- Tacrolimus
- Telavancin
- Telbivudine
- Telmisartan
- Temsirolimus
- Tetrabenazine
- Tetracaine
- Thiazide diuretics
- Thiazolidinediones
- Thiopental
- Thiothixene
- Tizanidine
- Tolvaptan
- Tranylcypromine
- Trazodone
- Triamterene
- Trimethoprim
- Valsartan
- Yohimbine
- Ziprasidone
