What's on this Page
What is Ticlopidine
Ticlopidine is an oral, platelet-aggregation inhibitor structurally related to clopidogrel.
Ticlopidine may be used as a second-line agent to prevent thromboembolism or stroke.
Rare cases of severe bone marrow toxicity limit ticlopidine’s use to patients who are intolerant or unresponsive to aspirin.
The use of ticlopidine has decreased with the availability of clopidogrel.
Clopidogrel is preferred to ticlopidine for the treatment of acute coronary syndromes (e.g., unstable angina or non-Q-wave MI, including patients undergoing PCI) due to its improved safety profile and shorter onset of action.
Ticlopidine has also been used for myocardial reinfarction prophylaxis; however, this is not an FDA-approved use. Ticlopidine was approved by the FDA in October 1991.
Brand Name
Ticlid
Indications
- acute myocardial infarction
- arterial thromboembolism prophylaxis
- claudication
- diabetic retinopathy
- myocardial infarction prophylaxis
- percutaneous coronary intervention (PCI)
- peripheral vascular disease (PVD)
- sickle cell disease
- stroke prophylaxis
- thrombosis prophylaxis
- transient ischemic attack
- unstable angina
Side Effects
- abdominal pain
- agranulocytosis
- anaphylactoid reactions
- angioedema
- anorexia
- aplastic anemia
- arthropathy
- asthenia
- cholestasis
- colitis
- diarrhea
- dizziness
- dyspepsia
- ecchymosis
- elevated hepatic enzymes
- eosinophilia
- epistaxis
- erythema multiforme
- exfoliative dermatitis
- flatulence
- GI bleeding
- headache
- hematuria
- hemolysis
- hemolytic anemia
- hepatic failure
- hepatic necrosis
- hepatitis
- hyperbilirubinemia
- hypercholesterolemia
- hypertriglyceridemia
- hyponatremia
- infection
- intracranial bleeding
- jaundice
- lupus-like symptoms
- maculopapular rash
- nausea
- nephrotic syndrome
- neutropenia
- new primary malignancy
- ocular hemorrhage
- pancytopenia
- peptic ulcer
- peripheral neuropathy
- platelet dysfunction
- pneumonitis
- prolonged bleeding time
- pruritus
- purpura
- rash
- renal failure (unspecified)
- serum sickness
- Stevens-Johnson syndrome
- thrombocytopenia
- thrombocytosis
- thrombotic thrombocytopenic purpura (TTP)
- tinnitus
- urticaria
- vasculitis
- vomiting
Monitoring Parameters
- CBC
- LFTs
- platelet count
Contraindications
- agranulocytosis
- aplastic anemia
- bleeding
- bone marrow suppression
- breast-feeding
- coagulopathy
- dental disease
- dental work
- geriatric
- GI bleeding
- hematological disease
- hemophilia
- hepatic disease
- hypercholesterolemia
- infection
- intracranial bleeding
- intramuscular injections
- jaundice
- labor
- leukemia
- neutropenia
- obstetric delivery
- peptic ulcer disease
- pregnancy
- renal disease
- renal failure
- renal impairment
- retinal bleeding
- surgery
- thienopyridine hypersensitivity
- thrombocytopenia
- thrombotic thrombocytopenic purpura (TTP)
- trauma
Interactions
- Abciximab
- Acetaminophen; Aspirin, ASA; Caffeine
- Ado-Trastuzumab emtansine
- Altretamine
- Aminolevulinic Acid
- Anagrelide
- Antacids
- Antimetabolites
- Antithrombin III
- Antithymocyte Globulin
- Apixaban
- Argatroban
- Arsenic Trioxide
- Aspirin, ASA
- Aspirin, ASA; Butalbital; Caffeine
- Aspirin, ASA; Butalbital; Caffeine; Codeine
- Aspirin, ASA; Caffeine; Dihydrocodeine
- Aspirin, ASA; Caffeine; Orphenadrine
- Aspirin, ASA; Carisoprodol
- Aspirin, ASA; Carisoprodol; Codeine
- Aspirin, ASA; Citric Acid; Sodium Bicarbonate
- Aspirin, ASA; Dipyridamole
- Aspirin, ASA; Omeprazole
- Aspirin, ASA; Oxycodone
- Aspirin, ASA; Pravastatin
- Betrixaban
- Bexarotene
- Bivalirudin
- Bupivacaine; Lidocaine
- Bupropion
- Bupropion; Naltrexone
- Calcium Carbonate
- Calcium Carbonate; Magnesium Hydroxide
- Calcium Carbonate; Risedronate
- Calcium Carbonate; Simethicone
- Cannabidiol
- Carbamazepine
- Carisoprodol
- Chlorambucil
- Cilostazol
- Cimetidine
- Citalopram
- Cladribine
- Clobazam
- Clofarabine
- Clopidogrel
- Collagenase
- Cyclophosphamide
- Cyclosporine
- Dabigatran
- Dalteparin
- Danaparoid
- Dasatinib
- Defibrotide
- Denileukin Diftitox
- Desirudin
- Desvenlafaxine
- Digoxin
- Dipyridamole
- Doxercalciferol
- Drotrecogin Alfa
- Duloxetine
- Edoxaban
- Enoxaparin
- Eptifibatide
- Escitalopram
- Esomeprazole
- Esomeprazole; Naproxen
- Estramustine
- Ethotoin
- Fish Oil, Omega-3 Fatty Acids (Dietary Supplements)
- Fludarabine
- Fluoxetine
- Fluoxetine; Olanzapine
- Fluvoxamine
- Folate analogs
- Fondaparinux
- Fosphenytoin
- Garlic, Allium sativum
- Ginger, Zingiber officinale
- Ginkgo, Ginkgo biloba
- Green Tea
- Heparin
- Hydantoins
- Ibritumomab Tiuxetan
- Ibrutinib
- Icosapent ethyl
- Iloprost
- Imatinib
- Inotersen
- Intravenous Lipid Emulsions
- Lepirudin
- Levomilnacipran
- Lidocaine
- Lidocaine; Prilocaine
- Lomustine, CCNU
- Loperamide
- Loperamide; Simethicone
- Mercaptopurine, 6-MP
- Methoxsalen
- Methylsulfonylmethane, MSM
- Milnacipran
- Mycophenolate
- Nelarabine
- Nonsteroidal antiinflammatory drugs
- Obinutuzumab
- Omeprazole; Sodium Bicarbonate
- Paroxetine
- Pegaspargase
- Pentosan
- Pentostatin
- Pentoxifylline
- Pexidartinib
- Phentermine; Topiramate
- Phenytoin
- Photosensitizing agents (topical)
- Platelet Glycoprotein IIb/IIIa Inhibitors
- Prasterone, Dehydroepiandrosterone, DHEA (Dietary Supplements)
- Prasterone, Dehydroepiandrosterone, DHEA (FDA-approved)
- Purine analogs
- Rasagiline
- Riluzole
- Rivaroxaban
- Selumetinib
- Sertraline
- Sodium Bicarbonate
- Sodium Hyaluronate, Hyaluronic Acid
- Sofosbuvir; Velpatasvir
- Sofosbuvir; Velpatasvir; Voxilaprevir
- Sulfinpyrazone
- Terbinafine
- Theophylline, Aminophylline
- Thioguanine, 6-TG
- Thrombolytic Agents
- Tinzaparin
- Tipranavir
- Tirofiban
- Tizanidine
- Tofacitinib
- Topiramate
- Trazodone
- Treprostinil
- Tretinoin, ATRA
- Venlafaxine
- Verteporfin
- Vilazodone
- Vorapaxar
- Vorinostat
- Vortioxetine
- Warfarin